API

Event: 1489

Key Event Title

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N/A, Steatohepatisis

Short name

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steatohepatitis

Biological Context

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Level of Biological Organization
Organ


Organ term

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Key Event Components

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Process Object Action

Key Event Overview


AOPs Including This Key Event

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Stressors

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Taxonomic Applicability

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Term Scientific Term Evidence Link
Vertebrates Vertebrates High NCBI

Life Stages

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Life stage Evidence
All life stages High

Sex Applicability

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Term Evidence
Unspecific High

Key Event Description

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Biological state: steatohepatisis is steatosis (fatty liver) presenting with inflammation. 

Biological compartment: liver.

Role in biology: Steatohepatisis is a disease and adverse endpoint. If this state continues, it will eventually lead to fibrosis and cirrhosis of the liver. 


How It Is Measured or Detected

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Steatohepatitis is typically measured histologically. Fatty liver is noticed by oil red O staining, although it also may be noted using lipidomics. Inflammatory cell infiltration is typically noted histologically. 


Domain of Applicability

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NASH (non-alcoholic steatohepatitis) can occur in any organism that contains a liver.


Regulatory Significance of the Adverse Outcome

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The precursor state to NASH (non-alcoholic steatohepatitis), steatosis, has been used in US EPA IRIS assessments as an adverse outcome. 


References

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