API

Aop: 100

AOP Title

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Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior

Short name:

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Cyclooxygenase inhibition 2

Authors

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Dalma Martinovic-Weigelt

Point of Contact

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Dalma Martinovic-Weigelt

Contributors

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  • Dalma Martinovic-Weigelt

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Inhibition, Cyclooxygenase activity September 16, 2017 10:14
Reduced, Prostaglandin F2alpha concentration, plasma December 03, 2016 16:37
Reduced, Prostaglandin F2alpha synthesis, ovary September 16, 2017 10:15
Reduced, Spawning behavior December 03, 2016 16:37
Reduced, Ability to attract spawning mates December 03, 2016 16:37
Reduced, Reproductive Success December 03, 2016 16:37
Decrease, Population trajectory September 26, 2017 11:33
Inhibition, Cyclooxygenase activity leads to Reduced, Prostaglandin F2alpha synthesis, ovary December 03, 2016 16:37
Reduced, Prostaglandin F2alpha concentration, plasma leads to Reduced, Spawning behavior December 03, 2016 16:37
Reduced, Ability to attract spawning mates leads to Reduced, Reproductive Success December 03, 2016 16:37
Reduced, Reproductive Success leads to Decrease, Population trajectory December 03, 2016 16:37
Reduced, Spawning behavior leads to Reduced, Ability to attract spawning mates December 03, 2016 16:37
Reduced, Prostaglandin F2alpha synthesis, ovary leads to Reduced, Prostaglandin F2alpha concentration, plasma December 03, 2016 16:37

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Inhibition, Cyclooxygenase activity Inhibition, Cyclooxygenase activity

Key Events

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Title Short name
Reduced, Prostaglandin F2alpha concentration, plasma Reduced, Prostaglandin F2alpha concentration, plasma
Reduced, Prostaglandin F2alpha synthesis, ovary Reduced, Prostaglandin F2alpha synthesis, ovary
Reduced, Spawning behavior Reduced, Spawning behavior
Reduced, Ability to attract spawning mates Reduced, Ability to attract spawning mates

Adverse Outcome

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Title Short name
Reduced, Reproductive Success Reduced, Reproductive Success
Decrease, Population trajectory Decrease, Population trajectory

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Life stage Evidence
Adult, reproductively mature Strong

Taxonomic Applicability

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Term Scientific Term Evidence Link
goldfish Carassius auratus Strong NCBI

Sex Applicability

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Sex Evidence
Female Strong

Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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