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Aop: 100

AOP Title

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Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior

Short name:

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Cyclooxygenase inhibition 2

Graphical Representation

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Click to download graphical representation template

Authors

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Dalma Martinovic-Weigelt

Point of Contact

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Dalma Martinovic-Weigelt   (email point of contact)

Contributors

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  • Dalma Martinovic-Weigelt

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on January 27, 2018 15:34

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Revision dates for related pages

Page Revision Date/Time
Inhibition, Cyclooxygenase activity September 16, 2017 10:14
Reduced, Prostaglandin F2alpha concentration, plasma December 03, 2016 16:37
Reduced, Prostaglandin F2alpha synthesis, ovary September 16, 2017 10:15
Reduced, Spawning behavior December 03, 2016 16:37
Reduced, Ability to attract spawning mates December 03, 2016 16:37
Reduced, Reproductive Success December 03, 2016 16:37
Decrease, Population trajectory September 26, 2017 11:33
Inhibition, Cyclooxygenase activity leads to Reduced, Prostaglandin F2alpha synthesis, ovary December 03, 2016 16:37
Reduced, Prostaglandin F2alpha concentration, plasma leads to Reduced, Spawning behavior December 03, 2016 16:37
Reduced, Ability to attract spawning mates leads to Reduced, Reproductive Success December 03, 2016 16:37
Reduced, Reproductive Success leads to Decrease, Population trajectory December 03, 2016 16:37
Reduced, Spawning behavior leads to Reduced, Ability to attract spawning mates December 03, 2016 16:37
Reduced, Prostaglandin F2alpha synthesis, ovary leads to Reduced, Prostaglandin F2alpha concentration, plasma December 03, 2016 16:37

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 79 Inhibition, Cyclooxygenase activity Inhibition, Cyclooxygenase activity
2 KE 671 Reduced, Prostaglandin F2alpha concentration, plasma Reduced, Prostaglandin F2alpha concentration, plasma
3 KE 672 Reduced, Prostaglandin F2alpha synthesis, ovary Reduced, Prostaglandin F2alpha synthesis, ovary
4 KE 673 Reduced, Spawning behavior Reduced, Spawning behavior
5 KE 674 Reduced, Ability to attract spawning mates Reduced, Ability to attract spawning mates
6 AO 675 Reduced, Reproductive Success Reduced, Reproductive Success
7 AO 360 Decrease, Population trajectory Decrease, Population trajectory

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Inhibition, Cyclooxygenase activity leads to Reduced, Prostaglandin F2alpha synthesis, ovary adjacent Low Low
Reduced, Prostaglandin F2alpha concentration, plasma leads to Reduced, Spawning behavior adjacent High Low
Reduced, Ability to attract spawning mates leads to Reduced, Reproductive Success adjacent Moderate Low
Reduced, Reproductive Success leads to Decrease, Population trajectory adjacent High High
Reduced, Spawning behavior leads to Reduced, Ability to attract spawning mates adjacent Moderate Low
Reduced, Prostaglandin F2alpha synthesis, ovary leads to Reduced, Prostaglandin F2alpha concentration, plasma adjacent Moderate Low

Network View

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Stressors

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Life Stage Applicability

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Life stage Evidence
Adult, reproductively mature High

Taxonomic Applicability

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Term Scientific Term Evidence Link
goldfish Carassius auratus High NCBI

Sex Applicability

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Sex Evidence
Female High

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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