API XML

Aop: 63

AOP Title

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Cyclooxygenase inhibition leading to reproductive dysfunction

Short name:

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Cyclooxygenase inhibition 1

Graphical Representation

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Click to download graphical representation template

Authors

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Dalma Martinovic-Weigelt, University of St. Thomas, MN; dalma@stthomas.edu

Point of Contact

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Dalma Martinovic-Weigelt   (email point of contact)

Contributors

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  • Dalma Martinovic-Weigelt

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on July 17, 2018 17:45

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Revision dates for related pages

Page Revision Date/Time
Reduced, Reproductive Success December 03, 2016 16:37
Inhibition, Cyclooxygenase activity September 16, 2017 10:14
Decrease, Ovulation September 16, 2017 10:15
Reduced, Prostaglandins, ovary September 16, 2017 10:15
Decrease, Population trajectory September 26, 2017 11:33
Reduced, Prostaglandins, ovary leads to Decrease, Ovulation December 03, 2016 16:37
Decrease, Ovulation leads to Reduced, Reproductive Success December 03, 2016 16:37
Inhibition, Cyclooxygenase activity leads to Reduced, Prostaglandins, ovary December 03, 2016 16:37
Reduced, Reproductive Success leads to Decrease, Population trajectory December 03, 2016 16:37

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 79 Inhibition, Cyclooxygenase activity Inhibition, Cyclooxygenase activity
2 KE 488 Decrease, Ovulation Decrease, Ovulation
3 KE 685 Reduced, Prostaglandins, ovary Reduced, Prostaglandins, ovary
4 AO 675 Reduced, Reproductive Success Reduced, Reproductive Success
5 AO 360 Decrease, Population trajectory Decrease, Population trajectory

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Reduced, Prostaglandins, ovary leads to Decrease, Ovulation adjacent Moderate Low
Decrease, Ovulation leads to Reduced, Reproductive Success adjacent High Moderate
Inhibition, Cyclooxygenase activity leads to Reduced, Prostaglandins, ovary adjacent
Reduced, Reproductive Success leads to Decrease, Population trajectory adjacent Moderate Low

Network View

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Stressors

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Life Stage Applicability

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Life stage Evidence
Adult, reproductively mature High

Taxonomic Applicability

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Term Scientific Term Evidence Link
goldfish Carassius auratus Moderate NCBI
human, mouse, rat human, mouse, rat NCBI

Sex Applicability

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Sex Evidence
Female High

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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