Aop: 63
AOP Title
Cyclooxygenase inhibition leading to reproductive dysfunction
Short name:
Cyclooxygenase inhibition 1Graphical Representation
Click to download graphical representation templateAuthors
Dalma Martinovic-Weigelt, University of St. Thomas, MN; dalma@stthomas.edu
Point of Contact
Dalma Martinovic-Weigelt (email point of contact)
Contributors
- Dalma Martinovic-Weigelt
Status
| Author status | OECD status | OECD project | SAAOP status |
|---|---|---|---|
| Under development: Not open for comment. Do not cite | 1.29 | Under Development |
This AOP was last modified on July 17, 2018 17:45
Revision dates for related pages
| Page | Revision Date/Time |
|---|---|
| Reduced, Reproductive Success | December 03, 2016 16:37 |
| Inhibition, Cyclooxygenase activity | September 16, 2017 10:14 |
| Decrease, Ovulation | September 16, 2017 10:15 |
| Reduced, Prostaglandins, ovary | September 16, 2017 10:15 |
| Decrease, Population trajectory | September 26, 2017 11:33 |
| Reduced, Prostaglandins, ovary leads to Decrease, Ovulation | December 03, 2016 16:37 |
| Decrease, Ovulation leads to Reduced, Reproductive Success | December 03, 2016 16:37 |
| Inhibition, Cyclooxygenase activity leads to Reduced, Prostaglandins, ovary | December 03, 2016 16:37 |
| Reduced, Reproductive Success leads to Decrease, Population trajectory | December 03, 2016 16:37 |
Abstract
Background (optional)
Summary of the AOP
Events: Molecular Initiating Events (MIE)
Key Events (KE) Adverse Outcomes (AO)| Sequence | Type | Event ID | Title | Short name |
|---|
| 1 | MIE | 79 | Inhibition, Cyclooxygenase activity | Inhibition, Cyclooxygenase activity |
| 2 | KE | 488 | Decrease, Ovulation | Decrease, Ovulation |
| 3 | KE | 685 | Reduced, Prostaglandins, ovary | Reduced, Prostaglandins, ovary |
| 4 | AO | 675 | Reduced, Reproductive Success | Reduced, Reproductive Success |
| 5 | AO | 360 | Decrease, Population trajectory | Decrease, Population trajectory |
Relationships Between Two Key Events
(Including MIEs and AOs)
| Title | Adjacency | Evidence | Quantitative Understanding |
|---|
| Reduced, Prostaglandins, ovary leads to Decrease, Ovulation | adjacent | Moderate | Low |
| Decrease, Ovulation leads to Reduced, Reproductive Success | adjacent | High | Moderate |
| Inhibition, Cyclooxygenase activity leads to Reduced, Prostaglandins, ovary | adjacent | ||
| Reduced, Reproductive Success leads to Decrease, Population trajectory | adjacent | Moderate | Low |
Network View
Stressors
Life Stage Applicability
| Life stage | Evidence |
|---|---|
| Adult, reproductively mature | High |
Taxonomic Applicability
| Term | Scientific Term | Evidence | Link |
|---|---|---|---|
| goldfish | Carassius auratus | Moderate | NCBI |
| human, mouse, rat | human, mouse, rat | NCBI |
Sex Applicability
| Sex | Evidence |
|---|---|
| Female | High |