API

Aop: 63

AOP Title

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Cyclooxygenase inhibition leading to reproductive dysfunction

Short name:

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Cyclooxygenase inhibition 1

Authors

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Dalma Martinovic-Weigelt, University of St. Thomas, MN; dalma@stthomas.edu

Point of Contact

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Dalma Martinovic-Weigelt

Contributors

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  • Dalma Martinovic-Weigelt

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Reduced, Reproductive Success December 03, 2016 16:37
Declining, Population trajectory December 03, 2016 16:37
Inhibition, Cyclooxygenase activity September 16, 2017 10:14
Decrease, Ovulation September 16, 2017 10:15
Reduced, Prostaglandins, ovary September 16, 2017 10:15
Reduced, Prostaglandins, ovary leads to Decrease, Ovulation December 03, 2016 16:37
Decrease, Ovulation leads to Reduced, Reproductive Success December 03, 2016 16:37
Reduced, Reproductive Success leads to Declining, Population trajectory December 03, 2016 16:37
Inhibition, Cyclooxygenase activity leads to Reduced, Prostaglandins, ovary December 03, 2016 16:37

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Inhibition, Cyclooxygenase activity Inhibition, Cyclooxygenase activity

Key Events

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Title Short name
Decrease, Ovulation Decrease, Ovulation
Reduced, Prostaglandins, ovary Reduced, Prostaglandins, ovary

Adverse Outcome

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Title Short name
Reduced, Reproductive Success Reduced, Reproductive Success
Declining, Population trajectory Declining, Population trajectory

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Life stage Evidence
Adult, reproductively mature Strong

Taxonomic Applicability

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Term Scientific Term Evidence Link
goldfish Carassius auratus Moderate NCBI
human, mouse, rat human, mouse, rat NCBI

Sex Applicability

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Sex Evidence
Female Strong

Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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