API XML

Aop: 339

AOP Title

?


DNA methyltransferase inhibition leading to population decline (#4)

Short name:

?

DNMT inhibtion leading to population decline (#4)

Graphical Representation

?

Click to download graphical representation template

W1siziisijiwmjavmdqvmzavmzn4y3lwdmfxyv9fcglhzw5fqu9qnc5ibxaixsxbinailcj0ahvtyiisijuwmhg1mdaixv0?sha=7ac8afaa7f0b90fb

Authors

?


You Song

Norwegian Institute for Water Research (NIVA)

Point of Contact

?


You Song   (email point of contact)

Contributors

?


  • You Song

Status

?

Author status OECD status OECD project SAAOP status
Under Development: Contributions and Comments Welcome Under Development


This AOP was last modified on May 01, 2020 13:36

?

Revision dates for related pages

Page Revision Date/Time
Increase, DNA methyltransferase inhibition April 22, 2019 05:09
Increase, DNA double-strand break April 30, 2020 12:28
Increase, Caspase transcription April 30, 2020 16:40
Increase, Ovarian somatic cell apoptosis April 30, 2020 16:56
Increase, Ovarian follicle breakdown April 30, 2020 16:56
Decrease, Oogenesis April 30, 2020 16:41
Decrease, Fecundity June 12, 2018 04:39
Decrease, Population trajectory September 26, 2017 11:33
5-Azacytidine April 22, 2019 05:01

Abstract

?



Background (optional)

?



Summary of the AOP

?


Events: Molecular Initiating Events (MIE)

?

Key Events (KE)

?

Adverse Outcomes (AO)

?

Sequence Type Event ID Title Short name
MIE 1619 Increase, DNA methyltransferase inhibition Increase, DNMT inhibition
KE 1766 Increase, DNA double-strand break Increase, DNA DSB
KE 1774 Increase, Caspase transcription Increase, Casp transcription
KE 1776 Increase, Ovarian somatic cell apoptosis Increase, Ovarian somatic cell apoptosis
KE 1777 Increase, Ovarian follicle breakdown Increase, Ovarian follicle breakdown
KE 1366 Decrease, Oogenesis Decrease, Oogenesis
AO 328 Decrease, Fecundity Decrease, Fecundity
AO 360 Decrease, Population trajectory Decrease, Population trajectory

Relationships Between Two Key Events
(Including MIEs and AOs)

?

Network View

?

 

Stressors

?

Name Evidence Term
5-Azacytidine High

Life Stage Applicability

?

Taxonomic Applicability

?

Sex Applicability

?

Overall Assessment of the AOP

?



Domain of Applicability

?


Essentiality of the Key Events

?


Evidence Assessment

?


Quantitative Understanding

?


Considerations for Potential Applications of the AOP (optional)

?



References

?