API XML

Aop: 337

AOP Title

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DNA methyltransferase inhibition leading to population decline (#2)

Short name:

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DNMT inhibtion leading to population decline (#2)

Graphical Representation

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Click to download graphical representation template

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Authors

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You Song

Norwegian Institute for Water Research (NIVA)

Point of Contact

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You Song   (email point of contact)

Contributors

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  • You Song

Status

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Author status OECD status OECD project SAAOP status
Under Development: Contributions and Comments Welcome Under Development


This AOP was last modified on May 01, 2020 13:37

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Revision dates for related pages

Page Revision Date/Time
Increase, DNA methyltransferase inhibition April 22, 2019 05:09
Decrease, Global DNA methylation April 30, 2020 16:40
Increase, Caspase transcription April 30, 2020 16:40
Increase, Ovarian somatic cell apoptosis April 30, 2020 16:56
Increase, Ovarian follicle breakdown April 30, 2020 16:56
Decrease, Oogenesis April 30, 2020 16:41
Decrease, Fecundity June 12, 2018 04:39
Decrease, Population trajectory September 26, 2017 11:33
Increase, DNMT inhibition leads to Decrease, Global DNA methylation April 30, 2020 16:43
Decrease, Global DNA methylation leads to Increase, Casp transcription April 30, 2020 16:43
Increase, Casp transcription leads to Increase, Ovarian somatic cell apoptosis April 30, 2020 16:58
Increase, Ovarian somatic cell apoptosis leads to Increase, Ovarian follicle breakdown April 30, 2020 16:59
Increase, Ovarian follicle breakdown leads to Decrease, Oogenesis April 30, 2020 16:59
Decrease, Oogenesis leads to Decrease, Fecundity June 12, 2018 04:41
Decrease, Fecundity leads to Decrease, Population trajectory April 22, 2019 05:00
5-Azacytidine April 22, 2019 05:01

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
MIE 1619 Increase, DNA methyltransferase inhibition Increase, DNMT inhibition
KE 1773 Decrease, Global DNA methylation Decrease, Global DNA methylation
KE 1774 Increase, Caspase transcription Increase, Casp transcription
KE 1776 Increase, Ovarian somatic cell apoptosis Increase, Ovarian somatic cell apoptosis
KE 1777 Increase, Ovarian follicle breakdown Increase, Ovarian follicle breakdown
KE 1366 Decrease, Oogenesis Decrease, Oogenesis
AO 328 Decrease, Fecundity Decrease, Fecundity
AO 360 Decrease, Population trajectory Decrease, Population trajectory

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Increase, DNMT inhibition leads to Decrease, Global DNA methylation adjacent High Low
Decrease, Global DNA methylation leads to Increase, Casp transcription adjacent Moderate Low
Increase, Casp transcription leads to Increase, Ovarian somatic cell apoptosis adjacent Moderate Low
Increase, Ovarian somatic cell apoptosis leads to Increase, Ovarian follicle breakdown adjacent Moderate Low
Increase, Ovarian follicle breakdown leads to Decrease, Oogenesis adjacent Moderate Low
Decrease, Oogenesis leads to Decrease, Fecundity adjacent Moderate Low
Decrease, Fecundity leads to Decrease, Population trajectory adjacent Moderate Low

Network View

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Stressors

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Name Evidence Term
5-Azacytidine High

Life Stage Applicability

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Life stage Evidence
Adult, reproductively mature Moderate

Taxonomic Applicability

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Term Scientific Term Evidence Link
Daphnia magna Daphnia magna Moderate NCBI

Sex Applicability

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Sex Evidence
Female Moderate

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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