API

Aop: 103

AOP Title

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Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint

Short name:

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Cyclooxygenase inhibition 5

Authors

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Dalma Martinovic-Wegelt

Point of Contact

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Dalma Martinovic-Weigelt

Contributors

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  • Dalma Martinovic-Weigelt

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Inhibition, Cyclooxygenase activity September 16, 2017 10:14
Reduced, Prostaglandin E2 concentration, hypothalamus September 16, 2017 10:15
Reduced, Gonadotropin releasing hormone, hypothalamus September 16, 2017 10:15
Reduced, Luteinizing hormone (LH), plasma September 16, 2017 10:15
Reduced, Maturation inducing steroid, plasma September 16, 2017 10:15
Reduced, Maturation inducing steroid receptor signalling, oocyte September 16, 2017 10:15
Upregulated, Spindle assembly checkpoint protein Mad2-oocyte September 16, 2017 10:15
Increased, Chromosome misseggregation September 16, 2017 10:15
Reduced, Reproductive Success December 03, 2016 16:37
Declining, Population trajectory December 03, 2016 16:37
Inhibition, Cyclooxygenase activity leads to Reduced, Prostaglandin E2 concentration, hypothalamus December 03, 2016 16:37
Reduced, Prostaglandin E2 concentration, hypothalamus leads to Reduced, Gonadotropin releasing hormone, hypothalamus December 03, 2016 16:37
Reduced, Gonadotropin releasing hormone, hypothalamus leads to Reduced, Luteinizing hormone (LH), plasma December 03, 2016 16:37
Reduced, Luteinizing hormone (LH), plasma leads to Reduced, Maturation inducing steroid, plasma December 03, 2016 16:37
Reduced, Maturation inducing steroid, plasma leads to Reduced, Maturation inducing steroid receptor signalling, oocyte December 03, 2016 16:37
Reduced, Maturation inducing steroid receptor signalling, oocyte leads to Upregulated, Spindle assembly checkpoint protein Mad2-oocyte December 03, 2016 16:37
Upregulated, Spindle assembly checkpoint protein Mad2-oocyte leads to Increased, Chromosome misseggregation December 03, 2016 16:37
Increased, Chromosome misseggregation leads to Reduced, Reproductive Success December 03, 2016 16:37
Reduced, Reproductive Success leads to Declining, Population trajectory December 03, 2016 16:37

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Inhibition, Cyclooxygenase activity Inhibition, Cyclooxygenase activity

Key Events

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Title Short name
Reduced, Prostaglandin E2 concentration, hypothalamus Reduced, Prostaglandin E2 concentration, hypothalamus
Reduced, Gonadotropin releasing hormone, hypothalamus Reduced, Gonadotropin releasing hormone, hypothalamus
Reduced, Luteinizing hormone (LH), plasma Reduced, Luteinizing hormone (LH), plasma
Reduced, Maturation inducing steroid, plasma Reduced, Maturation inducing steroid, plasma
Reduced, Maturation inducing steroid receptor signalling, oocyte Reduced, Maturation inducing steroid receptor signalling, oocyte
Upregulated, Spindle assembly checkpoint protein Mad2-oocyte Upregulated, Spindle assembly checkpoint protein Mad2-oocyte
Increased, Chromosome misseggregation Increased, Chromosome misseggregation

Adverse Outcome

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Title Short name
Reduced, Reproductive Success Reduced, Reproductive Success
Declining, Population trajectory Declining, Population trajectory

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Life stage Evidence
Adult, reproductively mature Strong

Taxonomic Applicability

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Term Scientific Term Evidence Link
Human, rat, mouse Human, rat, mouse NCBI
goldfish Carassius auratus Weak NCBI

Sex Applicability

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Sex Evidence
Female Strong

Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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