Aopwiki

Aop: 101

AOP Title
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Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release

Short name:
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Cyclooxygenase inhibition 3

Graphical Representation
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Click to download graphical representation template

Authors
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Dalma Martinovic-Weigelt

Point of Contact
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Dalma Martinovic-Weigelt (email point of contact)

Contributors

Dalma Martinovic-Weigelt

Status
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Author status	OECD status	OECD project	SAAOP status
Under development: Not open for comment. Do not cite		1.29	Under Development

This AOP was last modified on January 27, 2018 15:34
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Revision dates for related pages

Page	Revision Date/Time
Inhibition, Cyclooxygenase activity	September 16, 2017 10:14
Reduced, Ability to attract spawning mates	December 03, 2016 16:37
Reduced, Reproductive Success	December 03, 2016 16:37
Decline, Population trajectory	December 03, 2016 16:37
Reduced, Pheromone release	December 03, 2016 16:37
Decreased, Prostaglandin F2alpha synthesis, ovary	September 16, 2017 10:15
Reduced, Prostaglandin F2alpha concentration, plasma	December 03, 2016 16:37
Reduced, Pheromone release leads to Reduced, Ability to attract spawning mates	December 03, 2016 16:37
Reduced, Ability to attract spawning mates leads to Reduced, Reproductive Success	December 03, 2016 16:37
Reduced, Reproductive Success leads to Decline, Population trajectory	December 03, 2016 16:37
Inhibition, Cyclooxygenase activity leads to Decreased, Prostaglandin F2alpha synthesis, ovary	December 03, 2016 16:37
Decreased, Prostaglandin F2alpha synthesis, ovary leads to Reduced, Prostaglandin F2alpha concentration, plasma	December 03, 2016 16:37
Reduced, Prostaglandin F2alpha concentration, plasma leads to Reduced, Pheromone release	December 03, 2016 16:37

Abstract
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Background (optional)
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Summary of the AOP
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Events: Molecular Initiating Events (MIE)
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Key Events (KE)
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Adverse Outcomes (AO)
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Sequence	Type	Event ID	Title	Short name

1	MIE	79	Inhibition, Cyclooxygenase activity	Inhibition, Cyclooxygenase activity

2	KE	674	Reduced, Ability to attract spawning mates	Reduced, Ability to attract spawning mates
3	KE	678	Reduced, Pheromone release	Reduced, Pheromone release
4	KE	681	Decreased, Prostaglandin F2alpha synthesis, ovary	Decreased, Prostaglandin F2alpha synthesis, ovary
5	KE	671	Reduced, Prostaglandin F2alpha concentration, plasma	Reduced, Prostaglandin F2alpha concentration, plasma

6	AO	675	Reduced, Reproductive Success	Reduced, Reproductive Success
7	AO	679	Decline, Population trajectory	Decline, Population trajectory

Relationships Between Two Key Events
(Including MIEs and AOs)
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Title	Adjacency	Evidence	Quantitative Understanding

Reduced, Pheromone release leads to Reduced, Ability to attract spawning mates	adjacent	Moderate	Low
Reduced, Ability to attract spawning mates leads to Reduced, Reproductive Success	adjacent	High	Moderate
Reduced, Reproductive Success leads to Decline, Population trajectory	adjacent	High	High
Inhibition, Cyclooxygenase activity leads to Decreased, Prostaglandin F2alpha synthesis, ovary	adjacent	Low	Low
Decreased, Prostaglandin F2alpha synthesis, ovary leads to Reduced, Prostaglandin F2alpha concentration, plasma	adjacent	High	Low
Reduced, Prostaglandin F2alpha concentration, plasma leads to Reduced, Pheromone release	adjacent	High	Low

Network View
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Stressors
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Life Stage Applicability
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Life stage	Evidence
Adult, reproductively mature	High

Taxonomic Applicability
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Term	Scientific Term	Evidence	Link
goldfish	Carassius auratus	High	NCBI

Sex Applicability
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Sex	Evidence
Female	High

Overall Assessment of the AOP
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Domain of Applicability
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Essentiality of the Key Events
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Evidence Assessment
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Quantitative Understanding
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Considerations for Potential Applications of the AOP (optional)
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References
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