API XML

Aop: 341

AOP Title

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DNA methyltransferase inhibition leading to transgenerational effects (#2)

Short name:

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DNMT inhibtion leading to transgenerational effects (#2)

Graphical Representation

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Click to download graphical representation template

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Authors

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You Song

Norwegian Institute for Water Research (NIVA)

Point of Contact

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You Song   (email point of contact)

Contributors

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  • You Song

Status

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Author status OECD status OECD project SAAOP status
Under Development: Contributions and Comments Welcome Under Development


This AOP was last modified on May 01, 2020 13:35

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Revision dates for related pages

Page Revision Date/Time
Increase, DNA methyltransferase inhibition April 22, 2019 05:09
Decrease, Global DNA methylation April 30, 2020 16:40
Decrease, Heritable DNA methylation (F3) April 30, 2020 17:35
Increase, Caspase transcription (F3) April 30, 2020 17:35
Increase, Ovarian somatic cell apoptosis (F3) April 30, 2020 17:41
Increase, Ovarian follicle breakdown (F3) April 30, 2020 17:42
Decrease, Oogenesis (F3) April 30, 2020 17:37
Decrease, Fecundity (F3) April 30, 2020 17:36
Decrease, Population trajectory September 26, 2017 11:33
Increase, DNMT inhibition leads to Decrease, Global DNA methylation April 30, 2020 16:43
Decrease, Global DNA methylation leads to Decrease, Heritable DNA methylation (F3) April 30, 2020 17:37
Decrease, Heritable DNA methylation (F3) leads to Increase, Casp transcription (F3) April 30, 2020 17:38
Increase, Casp transcription (F3) leads to Increase, Ovarian somatic cell apoptosis (F3) April 30, 2020 17:44
Increase, Ovarian somatic cell apoptosis (F3) leads to Increase, Ovarian follicle breakdown (F3) April 30, 2020 17:44
Increase, Ovarian follicle breakdown (F3) leads to Decrease, Oogenesis (F3) April 30, 2020 17:44
Decrease, Oogenesis (F3) leads to Decrease, Fecundity (F3) April 30, 2020 17:38
Decrease, Fecundity (F3) leads to Decrease, Population trajectory April 30, 2020 17:39
5-Azacytidine April 22, 2019 05:01

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
MIE 1619 Increase, DNA methyltransferase inhibition Increase, DNMT inhibition
KE 1773 Decrease, Global DNA methylation Decrease, Global DNA methylation
KE 1778 Decrease, Heritable DNA methylation (F3) Decrease, Heritable DNA methylation (F3)
KE 1779 Increase, Caspase transcription (F3) Increase, Casp transcription (F3)
KE 1783 Increase, Ovarian somatic cell apoptosis (F3) Increase, Ovarian somatic cell apoptosis (F3)
KE 1784 Increase, Ovarian follicle breakdown (F3) Increase, Ovarian follicle breakdown (F3)
KE 1782 Decrease, Oogenesis (F3) Decrease, Oogenesis (F3)
AO 1781 Decrease, Fecundity (F3) Decrease, Fecundity (F3)
AO 360 Decrease, Population trajectory Decrease, Population trajectory

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Increase, DNMT inhibition leads to Decrease, Global DNA methylation adjacent High Low
Decrease, Global DNA methylation leads to Decrease, Heritable DNA methylation (F3) adjacent Moderate Low
Decrease, Heritable DNA methylation (F3) leads to Increase, Casp transcription (F3) adjacent Moderate Low
Increase, Casp transcription (F3) leads to Increase, Ovarian somatic cell apoptosis (F3) adjacent Moderate Low
Increase, Ovarian somatic cell apoptosis (F3) leads to Increase, Ovarian follicle breakdown (F3) adjacent Moderate Low
Increase, Ovarian follicle breakdown (F3) leads to Decrease, Oogenesis (F3) adjacent Moderate Low
Decrease, Oogenesis (F3) leads to Decrease, Fecundity (F3) adjacent Moderate Low
Decrease, Fecundity (F3) leads to Decrease, Population trajectory adjacent Moderate Low

Network View

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Stressors

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Name Evidence Term
5-Azacytidine High

Life Stage Applicability

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Life stage Evidence
Adult, reproductively mature Moderate

Taxonomic Applicability

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Term Scientific Term Evidence Link
Daphnia magna Daphnia magna Moderate NCBI

Sex Applicability

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Sex Evidence
Female Moderate

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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