API

Stressor: 47

Title

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Prochloraz

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
N-propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]-1H-imidazole-1-carboxamide DTXSID4024270 Prochloraz 67747-09-5 TVLSRXXIMLFWEO-UHFFFAOYSA-N TVLSRXXIMLFWEO-UHFFFAOYSA-N

AOP Evidence

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Event Evidence

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Inhibition, Aromatase

There is no evidence text for this event.



Antagonism, Androgen receptor

Using transiently AR-transfected CHO cells, prochloraz showed a LOEC of 6.3 uM and an IC50 of 13 uM (Kjærstad et al, 2010)



decrease, male anogenital distance

Prochloraz has been shown to cause decreased male AGD in rats following intrauterine exposure to 150-250 mg/kg bw/day (Laier et al, 2006; Noriega et al, 2005).



Decreased, Transcription of genes by AR

Using gene expression analysis of the androgen-regulated genes ornithine decarboxylase, prostatic binding protein C3 as well as insulin-like growth factor I. Gene expression levels were reduced in ventral prostates of male Wistar pups at postnatal day 16 following in utero and lactational exposure from maternal perinatal dosing with prochloraz (50 and 150 mg/kg/day) from gestational day 7 to postnatal day 16 (Laier et al. 2006). Also, using transiently AR-transfected CHO cells, prochloraz showed a LOEC of 6.3 mM and an IC50 of 13 mM (Kjærstad et al. 2010).




Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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References

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