AOPs Including This Stressor
|Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation||High|
Events Including This Stressor
|User term||DTXID||Preferred name||Casrn||jchem_inchi_key||indigo_inchi_key|
There is no evidence text for this AOP
There is no evidence text for this event.
Using transiently AR-transfected CHO cells, prochloraz showed a LOEC of 6.3 uM and an IC50 of 13 uM (Kjærstad et al, 2010)
Using gene expression analysis of the androgen-regulated genes ornithine decarboxylase, prostatic binding protein C3 as well as insulin-like growth factor I. Gene expression levels were reduced in ventral prostates of male Wistar pups at postnatal day 16 following in utero and lactational exposure from maternal perinatal dosing with prochloraz (50 and 150 mg/kg/day) from gestational day 7 to postnatal day 16 (Laier et al. 2006). Also, using transiently AR-transfected CHO cells, prochloraz showed a LOEC of 6.3 mM and an IC50 of 13 mM (Kjærstad et al. 2010).