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All Key Events

Showing 1 to 25 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

3	Reduction, 17beta-estradiol synthesis by ovarian granulosa cells Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	9 AOPs 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats 595: Emerging OPFRS reproductive outcome pathway
8	Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
9	Activation, 5HT2c Short Name Activation, 5HT2c	1	Molecular	Nov 29, 2016	Sep 16, 2017	33: Kidney toxicity induced by activation of 5HT2C
10	Acetylcholine accumulation in synapses Short Name ACh Synaptic Accumulation	1	Cellular	Nov 29, 2016	Jun 26, 2020	5 AOPs 16: Acetylcholinesterase inhibition leading to acute mortality 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 471: Neuron defect induced early behavioral change
12	Acetylcholinesterase (AchE) Inhibition Short Name AchE Inhibition	1	Cellular	Nov 29, 2016	Apr 29, 2020	7 AOPs 16: Acetylcholinesterase inhibition leading to acute mortality 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality 471: Neuron defect induced early behavioral change 559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
17	Altered gene expression, AHR nuclear translocator (ARNT)-dependent pathway Short Name	0	Molecular	Nov 29, 2016	Aug 19, 2021	2 AOPs 417: Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway 418: Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway
18	Activation, AhR Short Name Activation, AhR	2	Molecular	Nov 29, 2016	May 31, 2025	22 AOPs 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 57: AhR activation leading to hepatic steatosis 131: Aryl hydrocarbon receptor activation leading to uroporphyria 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 151: AhR activation leading to preeclampsia 414: Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway 415: Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway 416: Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway 417: Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway 418: Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway 419: Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway 420: Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway 439: Activation of the AhR leading to metastatic breast cancer 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 494: AhR activation leading to liver fibrosis 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis 578: AhR activation leading to cancer progression via immunosuppression 577: AhR activation leading to endometriosis
21	Altered regulation, Alpha hemoglobin Short Name Altered regulation, Alpha hemoglobin	1	Cellular	Nov 29, 2016	Sep 16, 2017	31: Oxidation of iron in hemoglobin leading to hematotoxicity
25	Agonism, Androgen receptor Short Name Agonism, Androgen receptor	1	Molecular	Nov 29, 2016	Nov 5, 2024	6 AOPs 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 376: Androgen receptor agonism leading to male-biased sex ratio 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 547: Androgen receptor agonism leading to long anogenital distance in female offspring 117: Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) 495: Androgen receptor activation leading to prostate cancer
26	Antagonism, Androgen receptor Short Name Antagonism, Androgen receptor	1	Molecular	Nov 29, 2016	Apr 5, 2024	9 AOPs 306: Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring 345: Androgen receptor (AR) antagonism leading to decreased fertility in females 372: Androgen receptor antagonism leading to testicular cancer 477: Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity 19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) 595: Emerging OPFRS reproductive outcome pathway 619: Androgen receptor antagonism leads to delayed preputial seperation via reduced fibroblast growth factor in genital-tubercle tissues
28	Reduction, Angiogenesis Short Name Reduction, Angiogenesis	1	Molecular	Nov 29, 2016	Jul 20, 2022	2 AOPs 43: Disruption of VEGFR Signaling Leading to Developmental Defects 614: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced vascular endothelial growth factor
29	Reduction in, Angiogenic sprouts Short Name Reduction in, Angiogenic sprouts	0		Nov 29, 2016	Nov 29, 2016	None
36	Inhibition, Aromatase Short Name Inhibition, Aromatase	1	Molecular	Nov 29, 2016	Apr 14, 2025	3 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
39	Increased Cholinergic Signaling Short Name Increased Cholinergic Signaling	3	Organ	Nov 29, 2016	Dec 20, 2019	3 AOPs 16: Acetylcholinesterase inhibition leading to acute mortality 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function
40	Mitochondrial ATP production, decreased Short Name Mitochondrial ATP production, decreased	1	Cellular	Nov 29, 2016	Oct 16, 2025	7 AOPs 26: Calcium-mediated neuronal ROS production and energy imbalance 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants 258: Renal protein alkylation leading to kidney toxicity 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 480: Mitochondrial complexes inhibition leading to heart failure via decreased ATP production 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity. 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
41	Inhibition, Bile Salt Export Pump (ABCB11) Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
46	Accumulation, Biological membranes Short Name Accumulation, Biological membranes	1	Cellular	Nov 29, 2016	Sep 16, 2017	35: Narcosis leading to respiratory failure
49	Reduction, Ca and HCO3 transport to shell gland Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	28: Cyclooxygenase inhibition leading reproductive failure
50	Increase, Ca++ (intracellular) Short Name Increase, Ca++ (intracellular)	1	Cellular	Nov 29, 2016	Sep 16, 2017	26: Calcium-mediated neuronal ROS production and energy imbalance
51	Inhibition, Ca++ ATPase Short Name Inhibition, Ca++ ATPase	1	Molecular	Nov 29, 2016	Sep 16, 2017	26: Calcium-mediated neuronal ROS production and energy imbalance
52	Decreased, Calcium influx Short Name Decreased, Calcium influx	1	Cellular	Nov 29, 2016	Jun 13, 2018	2 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
54	Up Regulation, CD36 Short Name Up Regulation, CD36	1	Molecular	Nov 29, 2016	Mar 26, 2024	5 AOPs 34: LXR activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis 57: AhR activation leading to hepatic steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis 517: Pregnane X Receptor (PXR) activation leads to liver steatosis
55	Increase, Cell injury/death Short Name Cell injury/death	1	Cellular	Nov 29, 2016	May 27, 2024	28 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 38: Protein Alkylation leading to Liver Fibrosis 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 144: Endocytic lysosomal uptake leading to liver fibrosis 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 278: IKK complex inhibition leading to liver injury 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 273: Mitochondrial complex inhibition leading to liver injury 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 265: Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium 264: Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity 268: Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms 494: AhR activation leading to liver fibrosis 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption 324: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and cell death 331: Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
57	Proliferation, Cell proliferation in the absence of cytotoxicity Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	1: Uncharacterized liver damage leading to hepatocellular carcinoma
59	Inhibition of Apoptosis in Altered Hepatic Foci, Changes in Cellular Growth Homeostasis Short Name	0		Nov 29, 2016	Nov 29, 2016	None