API

Aop: 153

AOP Title

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Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats

Short name:

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Aromatase Inhibition in Female Rats

Authors

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Point of Contact

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Tammy Stoker

Contributors

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  • Tammy Stoker

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol December 03, 2016 16:37
reduction in ovarian granulosa cells synthesis of estradiol, Reduced steroidogenic production of estradiol in granulosa cells December 03, 2016 16:37
Reduced Estradiol in Circulation, Reduced steroidogenic production of estradiol in granulosa cells leading to decreased estradiol in circulation December 03, 2016 16:37
Decreased positive estrogenic feedback on hypothalamus, Reduced estradiol in circulation decreases estrogen concentration at hypothalamus December 03, 2016 16:37
Decreased Kisspeptin release from neurons in AVPV, Decreased hypothalamic estrogen reduces kisspeptinergic neuron response December 03, 2016 16:37
Decreased GnRH Release, Decreased Kisspeptin stimulation of GnRH neurons September 16, 2017 10:16
Decreased LH release from Anterior Pituitary, Decreased GnRH stimulation of Anterior Pituitary Gonadotrophs December 03, 2016 16:37
Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation December 03, 2016 16:37
Decreased fertility, Reduced number of oocytes ovulated December 03, 2016 16:37
Letrozole November 29, 2016 18:42
Fadrozole November 29, 2016 18:42
1,2,4-triazole November 29, 2016 18:42

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Name Evidence Term
Letrozole
Fadrozole
1,2,4-triazole

Molecular Initiating Event

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Key Events

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Title Short name
reduction in ovarian granulosa cells synthesis of estradiol, Reduced steroidogenic production of estradiol in granulosa cells reduction in ovarian granulosa cells synthesis of estradiol, Reduced steroidogenic producti
Reduced Estradiol in Circulation, Reduced steroidogenic production of estradiol in granulosa cells leading to decreased estradiol in circulation Reduced Estradiol in Circulation, Reduced steroidogenic production of estradiol in granulos
Decreased positive estrogenic feedback on hypothalamus, Reduced estradiol in circulation decreases estrogen concentration at hypothalamus Decreased positive estrogenic feedback on hypothalamus, Reduced estradiol in circulation de
Decreased Kisspeptin release from neurons in AVPV, Decreased hypothalamic estrogen reduces kisspeptinergic neuron response Decreased Kisspeptin release from neurons in AVPV, Decreased hypothalamic estrogen reduces
Decreased GnRH Release, Decreased Kisspeptin stimulation of GnRH neurons Decreased GnRH Release, Decreased Kisspeptin stimulation of GnRH neurons
Decreased LH release from Anterior Pituitary, Decreased GnRH stimulation of Anterior Pituitary Gonadotrophs Decreased LH release from Anterior Pituitary, Decreased GnRH stimulation of Anterior Pituit
Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required f

Adverse Outcome

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Title Short name
Decreased fertility, Reduced number of oocytes ovulated Decreased fertility, Reduced number of oocytes ovulated

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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