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Aop: 153

AOP Title

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Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats

Short name:

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Aromatase Inhibition in Female Rats

Graphical Representation

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Click to download graphical representation template

Authors

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Point of Contact

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Tammy Stoker   (email point of contact)

Contributors

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  • Tammy Stoker

Status

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Author status OECD status OECD project SAAOP status
Under Development: Contributions and Comments Welcome 1.29 Under Development


This AOP was last modified on February 07, 2020 14:45

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Revision dates for related pages

Page Revision Date/Time
Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol December 03, 2016 16:37
reduction in ovarian granulosa cells synthesis of estradiol, Reduced steroidogenic production of estradiol in granulosa cells December 03, 2016 16:37
Reduced Estradiol in Circulation, Reduced steroidogenic production of estradiol in granulosa cells leading to decreased estradiol in circulation December 03, 2016 16:37
Decreased positive estrogenic feedback on hypothalamus, Reduced estradiol in circulation decreases estrogen concentration at hypothalamus December 03, 2016 16:37
Decreased Kisspeptin release from neurons in AVPV, Decreased hypothalamic estrogen reduces kisspeptinergic neuron response December 03, 2016 16:37
Decreased GnRH Release, Decreased Kisspeptin stimulation of GnRH neurons September 16, 2017 10:16
Decreased LH release from Anterior Pituitary, Decreased GnRH stimulation of Anterior Pituitary Gonadotrophs December 03, 2016 16:37
Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation May 19, 2020 16:39
Decreased fertility, Reduced number of oocytes ovulated December 03, 2016 16:37
Letrozole November 29, 2016 18:42
Fadrozole November 29, 2016 18:42
1,2,4-triazole November 29, 2016 18:42

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 964 Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle b
2 KE 965 reduction in ovarian granulosa cells synthesis of estradiol, Reduced steroidogenic production of estradiol in granulosa cells reduction in ovarian granulosa cells synthesis of estradiol, Reduced steroidogenic producti
3 KE 966 Reduced Estradiol in Circulation, Reduced steroidogenic production of estradiol in granulosa cells leading to decreased estradiol in circulation Reduced Estradiol in Circulation, Reduced steroidogenic production of estradiol in granulos
4 KE 967 Decreased positive estrogenic feedback on hypothalamus, Reduced estradiol in circulation decreases estrogen concentration at hypothalamus Decreased positive estrogenic feedback on hypothalamus, Reduced estradiol in circulation de
5 KE 968 Decreased Kisspeptin release from neurons in AVPV, Decreased hypothalamic estrogen reduces kisspeptinergic neuron response Decreased Kisspeptin release from neurons in AVPV, Decreased hypothalamic estrogen reduces
6 KE 969 Decreased GnRH Release, Decreased Kisspeptin stimulation of GnRH neurons Decreased GnRH Release, Decreased Kisspeptin stimulation of GnRH neurons
7 KE 970 Decreased LH release from Anterior Pituitary, Decreased GnRH stimulation of Anterior Pituitary Gonadotrophs Decreased LH release from Anterior Pituitary, Decreased GnRH stimulation of Anterior Pituit
8 KE 971 Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation Reduced Ovulation of oocytes
9 AO 972 Decreased fertility, Reduced number of oocytes ovulated Decreased fertility, Reduced number of oocytes ovulated

Relationships Between Two Key Events
(Including MIEs and AOs)

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Network View

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Stressors

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Name Evidence Term
Letrozole
Fadrozole
1,2,4-triazole

Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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