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  • <h1>SNAPSHOT</h1>
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  • <!-- Title Section, includes id, name and short name -->
  • <div id="title">
  • <h2>AOP ID and Title:</h2>
  • <hr>
  • <div class="title">
  • AOP 4: Ecdysone receptor agonism leading to mortality
  • </div>
  • <strong>Short Title: EcR agonism leading to mortality</strong>
  • <br>
  • <div class="title">AOP 4: Ecdysone receptor agonism leading to incomplete ecdysis associated mortality</div>
  • <strong>Short Title: EcR agonism leading to incomplete ecdysis associated mortality</strong>
  • </div>
  • <!-- Author section, includes text of author names as they have been entered by the user -->
  • <h2>Graphical Representation</h2>
  • <img src="https://aopwiki.org/system/dragonfly/production/2018/05/24/33t1hv5lkr_EcR_AOP_Song_et_al..jpg" height="500" width="700" alt=""/>
  • <div id="authors">
  • <h2>Authors</h2>
  • <hr>
  • <p>You Song<sup>1</sup> and Knut Erik Tollefsen<sup>1,2</sup><br />
  • <sup>1</sup> Norwegian Institute for Water Research (NIVA), Section of Ecotoxicology and Risk Assessment, Gaustadall&eacute;en 21, N-0349 Oslo, Norway<br />
  • <sup>2</sup> Norwegian University of Life Sciences (NMBU), Faculty of Environmental Science and Technology, Department of Environmental Sciences (IMV). P.O. Box 5003, N-1432 &Aring;s, Norway<br />
  • Contact: knut.erik.tollefsen@niva.no</p>
  • <sup>2</sup> Norwegian University of Life Sciences (NMBU), Faculty of Environmental Science and Technology, Department of Environmental Sciences (IMV). P.O. Box 5003, N-1432 &Aring;s, Norway</p>
  • <p>Contact: you.song@niva.no;&nbsp;knut.erik.tollefsen@niva.no</p>
  • <br>
  • </div>
  • <!-- Status Section, lists status of aop -->
  • <div id="status">
  • <h2>Status</h2>
  • <hr>
  • Open for citation & comment
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Author status</th>
  • <th scope="col">OECD status</th>
  • <th scope="col">OECD project</th>
  • <th scope="col">SAAOP status</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td>Open for citation &amp; comment</td>
  • <td></td>
  • <td></td>
  • <td>Under Development</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <br>
  • <!-- Abstract Section, text as generated by author -->
  • <div id="abstract">
  • <h2>Abstract</h2>
  • <hr>
  • <p>Molting is a natural biological process in arthropods. During a molt cycle, the animals generate new exoskeletons by the epidermis and shed the old ones in order to grow. Successful molting is key to survival, development and reproduction. Over half a century research on arthropod endocrinology reveals that molting is precisely controlled by complex multi-hormone systems, with 20-hydroxyecdysone (20E) being the key effective hormone to mediate different biological processes that are necessary for molting. The hormonal actions of 20E are exerted through binding and modulation of the ecdysone receptors (EcR), which are nuclear transcriptional factors that regulate a wide range of physiological and behavioral changes. Based on this knowledge, endocrine disrupting chemicals (EDCs) targeting at the EcRs are developed as pesticides and anti-parasite pharmaceuticals in order to disrupt the molting cycles of &ldquo;harmful&rdquo; arthropods and protect the agriculture and aquaculture. However, environmental residues of these EDCs may also affect non-target species, such as a number of crustaceans (e.g. crabs and lobsters) with great ecological and economical values, due to highly conserved endocrine systems in arthropods. Substantial efforts are therefore needed to assess the environmental hazards and risks of EDCs on non-target species. Due to the high number (over a million described) of species in the phylum of <em>Arthopoda</em>, it is not feasible to perform toxicity testing for each species as well as EDC. Construction of universal models on basis of systems (eco)toxicology and phylogenetic similarities for understanding the environmental endocrine disruption (ED) effects may serve as a potential solution. The current AOP is therefore developed based on available information in the databases to identify knowledge gaps in this research field. The conceptual AOP will be further expanded using a combination of laboratory studies and advance <em>in sillico</em> predictions of potential EcR ligands and taxonomic appllicablity to inform environmental risk assessment as an ultimate goal.</p>
  • <h2>Abstract</h2>
  • <p>Molting is a natural biological process in arthropods. During a molt cycle, the animals generate new exoskeletons by the epidermis and shed the old ones in order to grow. Successful molting is key to survival, development and reproduction. Over half a century research on arthropod endocrinology reveals that molting is precisely controlled by complex multi-hormone systems, with 20-hydroxyecdysone (20E) being the key effective hormone to mediate different biological processes that are necessary for molting. The hormonal actions of 20E are exerted through binding and modulation of the ecdysone receptors (EcR), which are nuclear transcriptional factors that regulate a wide range of physiological and behavioral changes. Based on this knowledge, endocrine disrupting chemicals (EDCs) targeting at the EcRs are developed as pesticides and anti-parasite pharmaceuticals in order to disrupt the molting cycles of &ldquo;harmful&rdquo; arthropods and protect the agriculture and aquaculture. However, environmental residues of these EDCs may also affect non-target species, such as a number of crustaceans (e.g. crabs and lobsters) with great ecological and economical values, due to highly conserved endocrine systems in arthropods. Substantial efforts are therefore needed to assess the environmental hazards and risks of EDCs on non-target species. Due to the high number (over a million described) of species in the phylum of <em>Arthopoda</em>, it is not feasible to perform toxicity testing for each species as well as EDC. Construction of universal models on basis of systems (eco)toxicology and phylogenetic similarities for understanding the environmental endocrine disruption (ED) effects may serve as a potential solution. The current AOP is therefore developed based on available information in the databases to identify knowledge gaps in this research field. The conceptual AOP will be further expanded using a combination of laboratory studies and advance <em>in sillico</em> predictions of potential EcR ligands and taxonomic appllicablity to inform environmental risk assessment as an ultimate goal.</p>
  • </div>
  • <br>
  • <div id="background">
  • </div>
  • <!-- AOP summary, includes summary of each of the events associated with this aop -->
  • <div id="aop_summary">
  • <h2>Summary of the AOP</h2>
  • <hr>
  • <!-- stressor table -->
  • <h3>Stressors</h3>
  • <br>
  • We will add things to here soon
  • <!-- mie table -->
  • <h3>Molecular Initiating Event</h3>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Title</th>
  • <th>Short name</th>
  • <th>Essentiality</th>
  • <h3>Events</h3>
  • <h3>Molecular Initiating Events (MIE), Key Events (KE), Adverse Outcomes (AO)</h3>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Sequence</th>
  • <th scope="col">Type</th>
  • <th scope="col">Event ID</th>
  • <th scope="col">Title</th>
  • <th scope="col">Short name</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>1</td>
  • <td>MIE</td>
  • <td>103</td>
  • <td><a href="/events/103">Increase, Ecdysone receptor agonism</a></td>
  • <td>Increase, EcR agonism</td>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td><a href="/events/103">Activation, Ecdysone receptor</a></td>
  • <td>Activation, EcR</td>
  • <td>Strong</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <!-- ke table -->
  • <h3>Key Events</h3>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Title</th>
  • <th>Short name</th>
  • <th>Essentiality</th>
  • <tr><td></td><td></td><td></td><td></td><td></td></tr>
  • <tr>
  • <td>2</td>
  • <td>KE</td>
  • <td>1264</td>
  • <td><a href="/events/1264">Increase, Nuclear receptor E75b gene expression</a></td>
  • <td>Increase, E75b expression</td>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td><a href="/events/988">Reduction, Release of circulating ecdysis triggering hormone</a></td>
  • <td>Reduction, Release of circulating ETH</td>
  • <td>Moderate</td>
  • </tr>
  • <tr>
  • <td><a href="/events/993">Reduction, Abdominal muscle contraction</a></td>
  • <td>Reduction, Abdominal muscle contraction</td>
  • <td>Moderate</td>
  • </tr>
  • <tr>
  • <td><a href="/events/990">Induction, Incomplete ecdysis</a></td>
  • <td>Induction, Incomplete ecdysis</td>
  • <td>Strong</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <!-- ao table -->
  • <h3>Adverse Outcomes</h3>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Title</th>
  • <th>Short name</th>
  • <th>Essentiality</th>
  • <tr>
  • <td>3</td>
  • <td>KE</td>
  • <td>1265</td>
  • <td><a href="/events/1265">Increase, Fushi tarazu factor-1 gene expression</a></td>
  • <td>Increase, Ftz-f1 expression</td>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td><a href="/events/351">Increased, Mortality</a></td>
  • <td>Increased, Mortality</td>
  • <td></td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <!-- rel table -->
  • <h3>Relationships between Key Events</h3>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Upstream Event</th>
  • <th>Relationship Type</th>
  • <th>Downstream Event</th>
  • <tr>
  • <td>4</td>
  • <td>KE</td>
  • <td>988</td>
  • <td><a href="/events/988">Decrease, Circulating ecdysis triggering hormone</a></td>
  • <td>Decrease, Circulating ETH</td>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>Activation, Ecdysone receptor</td>
  • <td>directly leads to</td>
  • <td>Reduction, Release of circulating ecdysis triggering hormone</td>
  • </tr>
  • <tr>
  • <td>Reduction, Release of circulating ecdysis triggering hormone</td>
  • <td>directly leads to</td>
  • <td>Reduction, Abdominal muscle contraction</td>
  • </tr>
  • <tr>
  • <td>Reduction, Abdominal muscle contraction</td>
  • <td>directly leads to</td>
  • <td>Induction, Incomplete ecdysis</td>
  • </tr>
  • <tr>
  • <td>Induction, Incomplete ecdysis</td>
  • <td>directly leads to</td>
  • <td>Increased, Mortality</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <!-- life stage and taxon tables -->
  • <div class="row">
  • <div class="col-md-6">
  • <h3>Life Stage Applicability</h3>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Life Stage</th>
  • <th>Evidence</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>Juvenile</td>
  • <td>Strong</td>
  • </tr>
  • <tr>
  • <td>Adult</td>
  • <td>Moderate</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • </div>
  • <div class="row">
  • <div class="col-md-10">
  • <h3>Taxon Applicability</h3>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Term</th>
  • <th>Scientific Term</th>
  • <th>Evidence</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>insects</td>
  • <td>insects</td>
  • <td>Strong</td>
  • </tr>
  • <tr>
  • <td>crustaceans</td>
  • <td>Daphnia magna</td>
  • <td>Moderate</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • </div>
  • <div class="row">
  • <div class="col-md-6">
  • <h3>Sex Applicability</h3>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Sex</th>
  • <th>Evidence</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>Unspecific</td>
  • <td>Moderate</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <tr>
  • <td>5</td>
  • <td>KE</td>
  • <td>1266</td>
  • <td><a href="/events/1266">Decrease, Circulating crustacean cardioactive peptide</a></td>
  • <td>Decrease, Circulating CCAP</td>
  • </tr>
  • <tr>
  • <td>6</td>
  • <td>KE</td>
  • <td>1267</td>
  • <td><a href="/events/1267">Decrease, Ecdysis motoneuron bursts</a></td>
  • <td>Decrease, Ecdysis motoneuron bursts</td>
  • </tr>
  • <tr>
  • <td>7</td>
  • <td>KE</td>
  • <td>1268</td>
  • <td><a href="/events/1268">Decrease, Excitatory postsynaptic potential</a></td>
  • <td>Decrease, Excitatory postsynaptic potential</td>
  • </tr>
  • <tr>
  • <td>8</td>
  • <td>KE</td>
  • <td>993</td>
  • <td><a href="/events/993">Decrease, Abdominal muscle contraction</a></td>
  • <td>Decrease, Abdominal muscle contraction</td>
  • </tr>
  • <tr>
  • <td>9</td>
  • <td>KE</td>
  • <td>990</td>
  • <td><a href="/events/990">Increase, Incomplete ecdysis</a></td>
  • <td>Increase, Incomplete ecdysis</td>
  • </tr>
  • <tr><td></td><td></td><td></td><td></td><td></td></tr>
  • <tr>
  • <td></td>
  • <td>AO</td>
  • <td>350</td>
  • <td><a href="/events/350">Increase, Mortality</a></td>
  • <td>Increase, Mortality</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <h3>Key Event Relationships</h3>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Upstream Event</th>
  • <th scope="col">Relationship Type</th>
  • <th scope="col">Downstream Event</th>
  • <th scope="col">Evidence</th>
  • <th scope="col">Quantitative Understanding</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td><a href="/relationships/1343">Increase, Ecdysone receptor agonism</a></td>
  • <td>adjacent</td>
  • <td>Increase, Nuclear receptor E75b gene expression</td>
  • <td>High</td>
  • <td>Low</td>
  • </tr>
  • <tr>
  • <td><a href="/relationships/1344">Increase, Nuclear receptor E75b gene expression</a></td>
  • <td>adjacent</td>
  • <td>Increase, Fushi tarazu factor-1 gene expression</td>
  • <td>High</td>
  • <td>Low</td>
  • </tr>
  • <tr>
  • <td><a href="/relationships/1345">Increase, Fushi tarazu factor-1 gene expression</a></td>
  • <td>adjacent</td>
  • <td>Decrease, Circulating ecdysis triggering hormone</td>
  • <td>Moderate</td>
  • <td>Low</td>
  • </tr>
  • <tr>
  • <td><a href="/relationships/1346">Decrease, Circulating ecdysis triggering hormone</a></td>
  • <td>adjacent</td>
  • <td>Decrease, Circulating crustacean cardioactive peptide</td>
  • <td>Moderate</td>
  • <td>Low</td>
  • </tr>
  • <tr>
  • <td><a href="/relationships/1347">Decrease, Circulating crustacean cardioactive peptide</a></td>
  • <td>adjacent</td>
  • <td>Decrease, Ecdysis motoneuron bursts</td>
  • <td>Moderate</td>
  • <td>Low</td>
  • </tr>
  • <tr>
  • <td><a href="/relationships/1348">Decrease, Ecdysis motoneuron bursts</a></td>
  • <td>adjacent</td>
  • <td>Decrease, Excitatory postsynaptic potential</td>
  • <td>Moderate</td>
  • <td>Low</td>
  • </tr>
  • <tr>
  • <td><a href="/relationships/1349">Decrease, Excitatory postsynaptic potential</a></td>
  • <td>adjacent</td>
  • <td>Decrease, Abdominal muscle contraction</td>
  • <td>Moderate</td>
  • <td>Low</td>
  • </tr>
  • <tr>
  • <td><a href="/relationships/1010">Decrease, Abdominal muscle contraction</a></td>
  • <td>adjacent</td>
  • <td>Increase, Incomplete ecdysis</td>
  • <td>Moderate</td>
  • <td>Low</td>
  • </tr>
  • <tr>
  • <td><a href="/relationships/1002">Increase, Incomplete ecdysis</a></td>
  • <td>adjacent</td>
  • <td>Increase, Mortality</td>
  • <td>High</td>
  • <td>High</td>
  • </tr>
  • <tr>
  • <td></td>
  • <td></td>
  • <td></td>
  • <td></td>
  • <td></td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <h3>Stressors</h3>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Name</th>
  • <th scope="col">Evidence</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td>Tebufenozide</td>
  • <td>High</td>
  • </tr>
  • <tr>
  • <td>20-hydroxyecdysone</td>
  • <td>High</td>
  • </tr>
  • <tr>
  • <td>Ponasterone A</td>
  • <td>High</td>
  • </tr>
  • <tr>
  • <td>Methoxyfenozide</td>
  • <td>High</td>
  • </tr>
  • <tr>
  • <td>Halofenozide</td>
  • <td>High</td>
  • </tr>
  • <tr>
  • <td>Chromafenozide</td>
  • <td>High</td>
  • </tr>
  • <tr>
  • <td>Cyasterone</td>
  • <td>High</td>
  • </tr>
  • <tr>
  • <td>Makisterone A</td>
  • <td>High</td>
  • </tr>
  • <tr>
  • <td>Inokosterone</td>
  • <td>High</td>
  • </tr>
  • <tr>
  • <td>Ecdysone</td>
  • <td>High</td>
  • </tr>
  • <tr>
  • <td>RH-5849</td>
  • <td>High</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- graphical representation -->
  • <h2>Graphical Representation</h2>
  • <img src="https://aopwiki.org/system/dragonfly/production/2017/02/09/6mr20psd65_EcR_AOP.jpg" , height="500" , width="700"> </img>
  • <!-- end graphical representation -->
  • <div id="overall_assessment">
  • <h2>Overall Assessment of the AOP</h2>
  • <h3>Domain of Applicability</h3>
  • <strong>Life Stage Applicability</strong>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Life Stage</th>
  • <th scope="col">Evidence</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td>Juvenile</td>
  • <td>High</td>
  • </tr>
  • <tr>
  • <td>Adult</td>
  • <td>High</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <strong>Taxonomic Applicability</strong>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Term</th>
  • <th scope="col">Scientific Term</th>
  • <th scope="col">Evidence</th>
  • <th scope="col">Links</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td>insects</td>
  • <td>insects</td>
  • <td>High</td>
  • <td><a href="http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=0" target="_blank">NCBI</a></td>
  • </tr>
  • <tr>
  • <td>crustaceans</td>
  • <td>Daphnia magna</td>
  • <td>Moderate</td>
  • <td><a href="http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=35525" target="_blank">NCBI</a></td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <strong>Sex Applicability</strong>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Sex</th>
  • <th scope="col">Evidence</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td>Unspecific</td>
  • <td>Moderate</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- end summary -->
  • <!-- loop for mie -->
  • <div id="mie">
  • <h2>Molecular Initating Event</h2>
  • <hr>
  • <div>
  • <div>
  • <h3><strong>Event ID and Title</strong></h3>
  • <a href="/events/103">103: Activation, Ecdysone receptor</a><br>
  • Short Name: Activation, EcR
  • </div>
  • <div id="considerations_for_potential_applicaitons">
  • </div>
  • <div>
  • <h3>Key Event Overview</h3>
  • <div id="references">
  • <h2>References</h2>
  • <p style="margin-left:12.9pt">Song, Y.; Villeneuve, D. L.; Toyota, K.; Iguchi, T.; Tollefsen, K. E., 2017. <strong>Ecdysone receptor agonism leading to lethal molting disruption in arthropods: review and adverse outcome pathway development</strong>. Environ Sci Technol, 51, (8), 4142-4157.</p>
  • <p style="margin-left:12.9pt">Song, Y., Evenseth, L.M., Iguchi, T., Tollefsen, K.E., 2017. <strong>Release of chitobiase as an indicator of potential molting disruption in juvenile <em>Daphnia magna</em> exposed to the ecdysone receptor agonist 20-hydroxyecdysone</strong>. J Toxicol Environ Health A, 1-9</p>
  • <p style="margin-left:12.9pt">Fay, K. A., Villeneuve, D. L., LaLone, C. A., Song, Y., Tollefsen, K. E. and Ankley, G. T., 2017. <strong>Practical approaches to adverse outcome pathway (AOP) development and weight of evidence evaluation as illustrated by ecotoxicological case studies</strong>. Environ. Toxicol. Chem. 36(6):1429-1449.</p>
  • <p style="margin-left:12.9pt">Miyakawa, H., Sato, T., Song, Y., Tollefsen, K.E., Iguchi, T., 2017. <strong>Ecdysteroid and juvenile hormone biosynthesis, receptors and their signaling in the freshwater microcrustacean <em>Daphnia</em></strong>. J Steroid Biochem Mol Biol. pii: S0960-0760(17), 30370-30379.</p>
  • <p style="margin-left:12.9pt">&nbsp;</p>
  • <!-- loop to find all aops that use this event -->
  • <h4>AOPs Including This Key Event</h4>
  • </div>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <div id="appendicies">
  • <h2>Appendix 1</h2>
  • <h3>List of MIEs in this AOP</h3>
  • <h4><a href="/events/103">Event: 103: Increase, Ecdysone receptor agonism</a></h4>
  • <h5>Short Name: Increase, EcR agonism</h5>
  • <h4>Key Event Component</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Process</th>
  • <th scope="col">Object</th>
  • <th scope="col">Action</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <th>AOP ID and Name</th>
  • <th>Event Type</th>
  • <th>Essentiality</th>
  • <td>ecdysone receptor-mediated signaling pathway</td>
  • <td>ecdysone receptor holocomplex</td>
  • <td>increased</td>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td><a href="/aops/4">4: Ecdysone receptor agonism leading to mortality</a></td>
  • <td>MolecularInitiatingEvent</td>
  • <td>Strong</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </tbody>
  • </table>
  • </div>
  • <!-- loop to find stressors under event -->
  • <div>
  • <h4>Stressors</h4>
  • The following are stressors that operate directly through this Event.
  • <div>
  • Will need to add a loop here once we have chemicals figured out
  • <ol>
  • <li>chemical one</li>
  • <li>chemical two</li>
  • </ol>
  • <br>
  • </div>
  • <h4>AOPs Including This Key Event</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP ID and Name</th>
  • <th scope="col">Event Type</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td><a href="/aops/4">Aop:4 - Ecdysone receptor agonism leading to incomplete ecdysis associated mortality</a></td>
  • <td>MolecularInitiatingEvent</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Stressors</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Name</th></tr>
  • </thead>
  • <tbody>
  • <tr><td>Methoxyfenozide</td></tr>
  • <tr><td>Halofenozide</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Biological Context</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Level of Biological Organization</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>Molecular</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Cell term</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Cell term</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>eukaryotic cell</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h3>List of Key Events in the AOP</h3>
  • <h4><a href="/events/1264">Event: 1264: Increase, Nuclear receptor E75b gene expression</a></h4>
  • <h5>Short Name: Increase, E75b expression</h5>
  • <h4>Key Event Component</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Process</th>
  • <th scope="col">Object</th>
  • <th scope="col">Action</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td>gene expression</td>
  • <td>Eip75B protein, Drosophila</td>
  • <td>increased</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <!-- loop to find taxonomic applicability under event -->
  • <div>
  • <h4>Taxonomic Applicability</h4>
  • There are no Taxonomic Terms associated with this Event
  • <br>
  • <br>
  • </div>
  • <!-- end loop for taxons -->
  • <!-- biological organization, life stages and sex terms -->
  • <div>
  • <div class="row">
  • <!-- biological organization -->
  • <div class="col-md-4">
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Level of Biological Organization</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>Molecular</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- end of bio org -->
  • <!-- life stages -->
  • <div class="col-md-4">
  • <h4>Life Stage Applicability</h4>
  • There are no Life Stages associated with this Event
  • </div>
  • <!-- end life stages -->
  • <!-- sex terms -->
  • <div class="col-md-4">
  • <h4>Sex Applicability</h4>
  • There are no Sexes associated with this Event
  • </div>
  • <!-- end sex terms -->
  • </div>
  • <!-- end bio org, life stage and sex terms -->
  • <h4>AOPs Including This Key Event</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP ID and Name</th>
  • <th scope="col">Event Type</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td><a href="/aops/4">Aop:4 - Ecdysone receptor agonism leading to incomplete ecdysis associated mortality</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Biological Context</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Level of Biological Organization</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>Molecular</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Cell term</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Cell term</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>eukaryotic cell</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h4><a href="/events/1265">Event: 1265: Increase, Fushi tarazu factor-1 gene expression</a></h4>
  • <h5>Short Name: Increase, Ftz-f1 expression</h5>
  • <h4>Key Event Component</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Process</th>
  • <th scope="col">Object</th>
  • <th scope="col">Action</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td>gene expression</td>
  • <td>nuclear hormone receptor FTZ-F1 (fruit fly)</td>
  • <td>increased</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <!-- event text -->
  • <!-- end event text -->
  • </div>
  • </div>
  • <!-- end mie -->
  • <!-- loop for key events -->
  • <div id="ke">
  • <h2>Key Events</h2>
  • <hr>
  • <div>
  • <div>
  • <h3><strong>Event ID and Title</strong></h3>
  • <a href="/events/988">988: Reduction, Release of circulating ecdysis triggering hormone</a><br>
  • Short Name: Reduction, Release of circulating ETH
  • <h4>AOPs Including This Key Event</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP ID and Name</th>
  • <th scope="col">Event Type</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td><a href="/aops/4">Aop:4 - Ecdysone receptor agonism leading to incomplete ecdysis associated mortality</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Biological Context</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Level of Biological Organization</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>Molecular</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Cell term</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Cell term</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>eukaryotic cell</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h4><a href="/events/988">Event: 988: Decrease, Circulating ecdysis triggering hormone</a></h4>
  • <h5>Short Name: Decrease, Circulating ETH</h5>
  • <h4>Key Event Component</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Process</th>
  • <th scope="col">Object</th>
  • <th scope="col">Action</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td>ecdysis-triggering hormone activity</td>
  • <td></td>
  • <td>decreased</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <div>
  • <h3>Key Event Overview</h3>
  • <!-- loop to find all aops that use this event -->
  • <h4>AOPs Including This Key Event</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <h4>AOPs Including This Key Event</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP ID and Name</th>
  • <th scope="col">Event Type</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td><a href="/aops/4">Aop:4 - Ecdysone receptor agonism leading to incomplete ecdysis associated mortality</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Biological Context</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Level of Biological Organization</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>Tissue</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h4><a href="/events/1266">Event: 1266: Decrease, Circulating crustacean cardioactive peptide</a></h4>
  • <h5>Short Name: Decrease, Circulating CCAP</h5>
  • <h4>Key Event Component</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Process</th>
  • <th scope="col">Object</th>
  • <th scope="col">Action</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <th>AOP ID and Name</th>
  • <th>Event Type</th>
  • <th>Essentiality</th>
  • <td>peptide secretion</td>
  • <td>cardioactive peptide (fruit fly)</td>
  • <td>decreased</td>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td><a href="/aops/4">4: Ecdysone receptor agonism leading to mortality</a></td>
  • <td>KeyEvent</td>
  • <td>Moderate</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </tbody>
  • </table>
  • </div>
  • <!-- loop to find stressors under event -->
  • <div>
  • <h4>Stressors</h4>
  • The following are stressors that operate directly through this Event.
  • <div>
  • Will need to add a loop here once we have chemicals figured out
  • <ol>
  • <li>chemical one</li>
  • <li>chemical two</li>
  • </ol>
  • <br>
  • </div>
  • <h4>AOPs Including This Key Event</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP ID and Name</th>
  • <th scope="col">Event Type</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td><a href="/aops/4">Aop:4 - Ecdysone receptor agonism leading to incomplete ecdysis associated mortality</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Biological Context</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Level of Biological Organization</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>Tissue</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Organ term</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Organ term</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>haemolymphatic fluid</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h4><a href="/events/1267">Event: 1267: Decrease, Ecdysis motoneuron bursts</a></h4>
  • <h5>Short Name: Decrease, Ecdysis motoneuron bursts</h5>
  • <h4>Key Event Component</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Process</th>
  • <th scope="col">Object</th>
  • <th scope="col">Action</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td>transmission of nerve impulse</td>
  • <td>motor neuron</td>
  • <td>decreased</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <!-- loop to find taxonomic applicability under event -->
  • <div>
  • <h4>Taxonomic Applicability</h4>
  • There are no Taxonomic Terms associated with this Event
  • <br>
  • <br>
  • </div>
  • <!-- end loop for taxons -->
  • <!-- biological organization, life stages and sex terms -->
  • <div>
  • <div class="row">
  • <!-- biological organization -->
  • <div class="col-md-4">
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Level of Biological Organization</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>Tissue</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- end of bio org -->
  • <!-- life stages -->
  • <div class="col-md-4">
  • <h4>Life Stage Applicability</h4>
  • There are no Life Stages associated with this Event
  • </div>
  • <!-- end life stages -->
  • <!-- sex terms -->
  • <div class="col-md-4">
  • <h4>Sex Applicability</h4>
  • There are no Sexes associated with this Event
  • </div>
  • <!-- end sex terms -->
  • </div>
  • <!-- end bio org, life stage and sex terms -->
  • <h4>AOPs Including This Key Event</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP ID and Name</th>
  • <th scope="col">Event Type</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td><a href="/aops/4">Aop:4 - Ecdysone receptor agonism leading to incomplete ecdysis associated mortality</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Biological Context</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Level of Biological Organization</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>Tissue</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Organ term</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Organ term</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>nervous system</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h4><a href="/events/1268">Event: 1268: Decrease, Excitatory postsynaptic potential</a></h4>
  • <h5>Short Name: Decrease, Excitatory postsynaptic potential</h5>
  • <h4>Key Event Component</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Process</th>
  • <th scope="col">Object</th>
  • <th scope="col">Action</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td>excitatory postsynaptic potential</td>
  • <td></td>
  • <td>decreased</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <!-- event text -->
  • <h4>AOPs Including This Key Event</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP ID and Name</th>
  • <th scope="col">Event Type</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td><a href="/aops/4">Aop:4 - Ecdysone receptor agonism leading to incomplete ecdysis associated mortality</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Biological Context</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Level of Biological Organization</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>Tissue</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Organ term</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Organ term</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>somatic muscle</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h4><a href="/events/993">Event: 993: Decrease, Abdominal muscle contraction</a></h4>
  • <h5>Short Name: Decrease, Abdominal muscle contraction</h5>
  • <h4>Key Event Component</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Process</th>
  • <th scope="col">Object</th>
  • <th scope="col">Action</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td>muscle contraction</td>
  • <td></td>
  • <td>increased</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <!-- end event text -->
  • </div>
  • <h4>AOPs Including This Key Event</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP ID and Name</th>
  • <th scope="col">Event Type</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td><a href="/aops/4">Aop:4 - Ecdysone receptor agonism leading to incomplete ecdysis associated mortality</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Biological Context</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Level of Biological Organization</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>Tissue</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Organ term</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Organ term</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>somatic muscle</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h4><a href="/events/990">Event: 990: Increase, Incomplete ecdysis</a></h4>
  • <h5>Short Name: Increase, Incomplete ecdysis</h5>
  • <h4>Key Event Component</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Process</th>
  • <th scope="col">Object</th>
  • <th scope="col">Action</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td>chitin biosynthetic process</td>
  • <td>chitin</td>
  • <td>increased</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <div>
  • <div>
  • <h3><strong>Event ID and Title</strong></h3>
  • <a href="/events/993">993: Reduction, Abdominal muscle contraction</a><br>
  • Short Name: Reduction, Abdominal muscle contraction
  • <h4>AOPs Including This Key Event</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP ID and Name</th>
  • <th scope="col">Event Type</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td><a href="/aops/4">Aop:4 - Ecdysone receptor agonism leading to incomplete ecdysis associated mortality</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/466">Aop:466 - Doda decarboxylase leading to mortality</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/467">Aop:467 - Knickkopf leading to mortality</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Biological Context</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Level of Biological Organization</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>Individual</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <div>
  • <h3>Key Event Overview</h3>
  • <!-- loop to find all aops that use this event -->
  • <h4>AOPs Including This Key Event</h4>
  • <h3>List of Adverse Outcomes in this AOP</h3>
  • <h4><a href="/events/350">Event: 350: Increase, Mortality</a></h4>
  • <h5>Short Name: Increase, Mortality</h5>
  • <h4>Key Event Component</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Process</th>
  • <th scope="col">Object</th>
  • <th scope="col">Action</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td>mortality</td>
  • <td></td>
  • <td>increased</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <h4>AOPs Including This Key Event</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP ID and Name</th>
  • <th scope="col">Event Type</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td><a href="/aops/4">Aop:4 - Ecdysone receptor agonism leading to incomplete ecdysis associated mortality</a></td>
  • <td>AdverseOutcome</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/331">Aop:331 - Formation of DNA photoproducts leading to growth inhibition (1)</a></td>
  • <td>AdverseOutcome</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/327">Aop:327 - Excessive reactive oxygen species production leading to mortality (1)</a></td>
  • <td>AdverseOutcome</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/328">Aop:328 - Excessive reactive oxygen species production leading to mortality (2)</a></td>
  • <td>AdverseOutcome</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/329">Aop:329 - Excessive reactive oxygen species production leading to mortality (3)</a></td>
  • <td>AdverseOutcome</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/330">Aop:330 - Excessive reactive oxygen species production leading to mortality (4)</a></td>
  • <td>AdverseOutcome</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/343">Aop:343 - S-adenosylmethionine depletion leading to population decline (2)</a></td>
  • <td>AdverseOutcome</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/342">Aop:342 - S-adenosylmethionine depletion leading to population decline (1)</a></td>
  • <td>AdverseOutcome</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/358">Aop:358 - Chitinase inhibition leading to mortality</a></td>
  • <td>AdverseOutcome</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/359">Aop:359 - Chitobiase inhibition leading to mortality</a></td>
  • <td>AdverseOutcome</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/360">Aop:360 - Chitin synthase 1 inhibition leading to mortality</a></td>
  • <td>AdverseOutcome</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/361">Aop:361 - Sulfonylureareceptor binding leading to mortality</a></td>
  • <td>AdverseOutcome</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/465">Aop:465 - Alcohol dehydrogenase leading to reproductive dysfunction</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/466">Aop:466 - Doda decarboxylase leading to mortality</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/467">Aop:467 - Knickkopf leading to mortality</a></td>
  • <td>KeyEvent</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/479">Aop:479 - Mitochondrial complexes inhibition leading to heart failure via increased myocardial oxidative stress</a></td>
  • <td>AdverseOutcome</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/480">Aop:480 - Mitochondrial complexes inhibition leading to heart failure via decreased ATP production</a></td>
  • <td>AdverseOutcome</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/471">Aop:471 - Various neuronal effects induced by elavl3, sox10, and mbp</a></td>
  • <td>AdverseOutcome</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Stressors</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Name</th></tr>
  • </thead>
  • <tbody>
  • <tr><td>Polyoxin D</td></tr>
  • <tr><td>Nikkomycins</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Biological Context</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr><th scope="col">Level of Biological Organization</th></tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr><td>Individual</td></tr>
  • </tbody>
  • </table>
  • </div>
  • <h4>Domain of Applicability</h4>
  • <strong>Taxonomic Applicability</strong>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Term</th>
  • <th scope="col">Scientific Term</th>
  • <th scope="col">Evidence</th>
  • <th scope="col">Links</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td>Lucilia cuprina</td>
  • <td>Lucilia cuprina</td>
  • <td>High</td>
  • <td><a href="http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=7375" target="_blank">NCBI</a></td>
  • </tr>
  • <tr>
  • <td>Daphnia magna</td>
  • <td>Daphnia magna</td>
  • <td>High</td>
  • <td><a href="http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=35525" target="_blank">NCBI</a></td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <strong>Life Stage Applicability</strong>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Life Stage</th>
  • <th scope="col">Evidence</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td>All life stages</td>
  • <td>High</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <strong>Sex Applicability</strong>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">Sex</th>
  • <th scope="col">Evidence</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td>Unspecific</td>
  • <td>High</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <p><span style="font-size:14px"><strong>Taxonomic: </strong>This AO is applicable to all living organisms.</span></p>
  • <p><span style="font-size:14px"><strong>Life stage: </strong>This AO&nbsp;is applicable to all life stages.</span></p>
  • <p><span style="font-size:14px"><strong>Sex: </strong>This AO is applicable to all sexes.</span></p>
  • <p><span style="font-size:14px"><strong>Chemical:</strong> Substances known to increase mortality in arthropods are of the family of pyrimidine nucleosides (e.g. polyoxin D and nikkomycin Z) (Gijswijt et al. 1979; Tellam et al. 2000; Arakawa et al. 2008).</span></p>
  • <h4>Key Event Description</h4>
  • <p><span style="font-size:14px">This key event is observed at the biological level of the individual and describes the increase of mortality of individuals upon exposure to a stressor.</span></p>
  • <h4>How it is Measured or Detected</h4>
  • <p><span style="font-size:14px">The AO can be detected by observation, for example by immobilization of the respective organisms. There exist guidelines for the characterization of this AO in arthropods. For example, the OECD 202 Daphnia sp. Acute immobilization test&nbsp;</span><!--[if supportFields]><span lang=EN-US
  • style='font-size:11.0pt;line-height:107%;font-family:"Calibri",sans-serif;
  • mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font:
  • minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:"Times New Roman";
  • mso-bidi-theme-font:minor-bidi;mso-ansi-language:EN-US;mso-fareast-language:
  • EN-US;mso-bidi-language:AR-SA'><span style='mso-element:field-begin;mso-field-lock:
  • yes'></span>ADDIN CSL_CITATION
  • {&quot;citationItems&quot;:[{&quot;id&quot;:&quot;ITEM-1&quot;,&quot;itemData&quot;:{&quot;DOI&quot;:&quot;10.1787/9789264069947-en&quot;,&quot;ISBN&quot;:&quot;9789264069947&quot;,&quot;PMID&quot;:&quot;128&quot;,&quot;abstract&quot;:&quot;This
  • Test Guideline describes an acute toxicity test to assess effects of chemicals
  • towards daphnids (usually Daphnia magna Staus). Young daphnids, aged less than
  • 24 hours at the start of the test, are exposed to the test substance at a range
  • of concentrations (at least five concentrations) for a period of 48 hours.
  • Immobilisation is recorded at 24 hours and 48 hours and compared with control
  • values. The results are analysed in order to calculate the EC50 at 48h. Determination
  • of the EC50 at 24h is optional. At least 20 animals, preferably divided into
  • four groups of five animals each, should be used at each test concentration and
  • for the controls. At least 2 ml of test solution should be provided for each
  • animal (i.e. a volume of 10 ml for five daphnids per test vessel). The limit
  • test corresponds to one dose level of 100 mg/L. The study report should include
  • the observation for immobilized daphnids at 24 and 48 hours after the beginning
  • of the test and the measures of dissolved oxygen, pH, concentration of the test
  • substance, at the beginning and end of the
  • test.&quot;,&quot;author&quot;:[{&quot;dropping-particle&quot;:&quot;&quot;,&quot;family&quot;:&quot;OECD&quot;,&quot;given&quot;:&quot;&quot;,&quot;non-dropping-particle&quot;:&quot;&quot;,&quot;parse-names&quot;:false,&quot;suffix&quot;:&quot;&quot;}],&quot;collection-title&quot;:&quot;OECD
  • Guidelines for the Testing of Chemicals, Section
  • 2&quot;,&quot;container-title&quot;:&quot;OECD
  • Publishing&quot;,&quot;id&quot;:&quot;ITEM-1&quot;,&quot;issue&quot;:&quot;OECD
  • Guideline for the Testing of Chemicals, Section
  • 2&quot;,&quot;issued&quot;:{&quot;date-parts&quot;:[[&quot;2004&quot;,&quot;11&quot;,&quot;23&quot;]]},&quot;number-of-pages&quot;:&quot;1-12&quot;,&quot;publisher&quot;:&quot;OECD&quot;,&quot;title&quot;:&quot;Test
  • No. 202: &lt;i&gt;Daphnia sp.&lt;/i&gt; Acute Immobilisation
  • Test&quot;,&quot;type&quot;:&quot;report&quot;},&quot;uris&quot;:[&quot;http://www.mendeley.com/documents/?uuid=53ebeac3-a1c9-3977-9697-df1efabeb4d3&quot;]}],&quot;mendeley&quot;:{&quot;formattedCitation&quot;:&quot;(OECD
  • 2004)&quot;,&quot;plainTextFormattedCitation&quot;:&quot;(OECD
  • 2004)&quot;},&quot;properties&quot;:{&quot;noteIndex&quot;:0},&quot;schema&quot;:&quot;https://github.com/citation-style-language/schema/raw/master/csl-citation.json&quot;}<span
  • style='mso-element:field-separator'></span></span><![endif]-->(OECD 2004)<!--[if supportFields]><span
  • lang=EN-US style='font-size:11.0pt;line-height:107%;font-family:"Calibri",sans-serif;
  • mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calibri;mso-fareast-theme-font:
  • minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:"Times New Roman";
  • mso-bidi-theme-font:minor-bidi;mso-ansi-language:EN-US;mso-fareast-language:
  • EN-US;mso-bidi-language:AR-SA'><span style='mso-element:field-end'></span></span><![endif]--><span style="font-size:14px"> which can also be modified depending on the effect one expects.</span></p>
  • <h4>Regulatory Significance of the AO</h4>
  • <p><span style="font-size:14px">The Adverse Outcome is highly significant from a regulatory point of view. It is employed as regulatory endpoint in most studies assessing the toxicity of stressors.</span></p>
  • <h4>References</h4>
  • <p><span style="font-size:14px">Arakawa T, Yukuhiro F, Noda H. 2008. Insecticidal effect of a fungicide containing polyoxin B on the larvae of <em>Bombyx mori</em> (Lepidoptera: Bombycidae), <em>Mamestra brassicae</em>, <em>Mythimna separata</em>, and <em>Spodoptera litura</em> (Lepidoptera: Noctuidae). Appl Entomol Zool. 43(2):173&ndash;181. doi:10.1303/aez.2008.173.</span></p>
  • <p><span style="font-size:14px">Gijswijt MJ, Deul DH, de Jong BJ. 1979. Inhibition of chitin synthesis by benzoyl-phenylurea insecticides, III. Similarity in action in <em>Pieris brassicae</em> (L.) with Polyoxin D. Pestic Biochem Physiol. 12(1):87&ndash;94. doi:10.1016/0048-3575(79)90098-1.</span></p>
  • <p><span style="font-size:14px">OECD. 2004. Test No. 202: <em>Daphnia sp.</em> Acute Immobilisation Test. OECD OECD Guidelines for the Testing of Chemicals, Section 2. [accessed 2020 Mar 3]. https://www.oecd-ilibrary.org/environment/test-no-202-daphnia-sp-acute-immobilisation-test_9789264069947-en.</span></p>
  • <p><span style="font-size:14px">Tellam RL, Vuocolo T, Johnson SE, Jarmey J, Pearson RD. 2000. Insect chitin synthase. cDNA sequence, gene organization and expression. Eur J Biochem. 267(19):6025&ndash;6043. doi:10.1046/j.1432-1327.2000.01679.x.</span></p>
  • <h2>Appendix 2</h2>
  • <h2>List of Key Event Relationships in the AOP</h2>
  • <div id="evidence_supporting_links">
  • <h3>List of Adjacent Key Event Relationships</h3>
  • <div>
  • <h4><a href="/relationships/1343">Relationship: 1343: Increase, EcR agonism leads to Increase, E75b expression</a></h4>
  • <h4>AOPs Referencing Relationship</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th>AOP ID and Name</th>
  • <th>Event Type</th>
  • <th>Essentiality</th>
  • <th scope="col">AOP Name</th>
  • <th scope="col">Adjacency</th>
  • <th scope="col">Weight of Evidence</th>
  • <th scope="col">Quantitative Understanding</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td><a href="/aops/4">4: Ecdysone receptor agonism leading to mortality</a></td>
  • <td>KeyEvent</td>
  • <td>Moderate</td>
  • </tr>
  • <tbody class="tbody-striped">
  • <tr>
  • <td><a href="/aops/4">Ecdysone receptor agonism leading to incomplete ecdysis associated mortality</a></td>
  • <td>adjacent</td>
  • <td>High</td>
  • <td>Low</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- loop to find stressors under event -->
  • <div>
  • <h4>Stressors</h4>
  • The following are stressors that operate directly through this Event.
  • <div>
  • Will need to add a loop here once we have chemicals figured out
  • <ol>
  • <li>chemical one</li>
  • <li>chemical two</li>
  • </ol>
  • <br>
  • </div>
  • </div>
  • <!-- loop to find taxonomic applicability under event -->
  • <div>
  • <h4>Taxonomic Applicability</h4>
  • There are no Taxonomic Terms associated with this Event
  • <br>
  • <br>
  • </div>
  • <!-- end loop for taxons -->
  • <!-- biological organization, life stages and sex terms -->
  • <div>
  • <div class="row">
  • <!-- biological organization -->
  • <div class="col-md-4">
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Level of Biological Organization</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>Tissue</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- end of bio org -->
  • <!-- life stages -->
  • <div class="col-md-4">
  • <h4>Life Stage Applicability</h4>
  • There are no Life Stages associated with this Event
  • </div>
  • <!-- end life stages -->
  • <!-- sex terms -->
  • <div class="col-md-4">
  • <h4>Sex Applicability</h4>
  • There are no Sexes associated with this Event
  • </div>
  • <!-- end sex terms -->
  • </div>
  • <!-- end bio org, life stage and sex terms -->
  • </div>
  • <!-- event text -->
  • <!-- end event text -->
  • </div>
  • <div>
  • <div>
  • <h3><strong>Event ID and Title</strong></h3>
  • <a href="/events/990">990: Induction, Incomplete ecdysis</a><br>
  • Short Name: Induction, Incomplete ecdysis
  • </div>
  • <div>
  • <h3>Key Event Overview</h3>
  • <!-- loop to find all aops that use this event -->
  • <h4>AOPs Including This Key Event</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <div>
  • <h4><a href="/relationships/1344">Relationship: 1344: Increase, E75b expression leads to Increase, Ftz-f1 expression</a></h4>
  • <h4>AOPs Referencing Relationship</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th>AOP ID and Name</th>
  • <th>Event Type</th>
  • <th>Essentiality</th>
  • <th scope="col">AOP Name</th>
  • <th scope="col">Adjacency</th>
  • <th scope="col">Weight of Evidence</th>
  • <th scope="col">Quantitative Understanding</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td><a href="/aops/4">4: Ecdysone receptor agonism leading to mortality</a></td>
  • <td>KeyEvent</td>
  • <td>Strong</td>
  • </tr>
  • <tbody class="tbody-striped">
  • <tr>
  • <td><a href="/aops/4">Ecdysone receptor agonism leading to incomplete ecdysis associated mortality</a></td>
  • <td>adjacent</td>
  • <td>High</td>
  • <td>Low</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- loop to find stressors under event -->
  • <div>
  • <h4>Stressors</h4>
  • The following are stressors that operate directly through this Event.
  • <div>
  • Will need to add a loop here once we have chemicals figured out
  • <ol>
  • <li>chemical one</li>
  • <li>chemical two</li>
  • </ol>
  • <br>
  • </div>
  • </div>
  • <!-- loop to find taxonomic applicability under event -->
  • <div>
  • <h4>Taxonomic Applicability</h4>
  • There are no Taxonomic Terms associated with this Event
  • <br>
  • <br>
  • </div>
  • <!-- end loop for taxons -->
  • <!-- biological organization, life stages and sex terms -->
  • <div>
  • <div class="row">
  • <!-- biological organization -->
  • <div class="col-md-4">
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Level of Biological Organization</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>Individual</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- end of bio org -->
  • <!-- life stages -->
  • <div class="col-md-4">
  • <h4>Life Stage Applicability</h4>
  • There are no Life Stages associated with this Event
  • </div>
  • <!-- end life stages -->
  • <!-- sex terms -->
  • <div class="col-md-4">
  • <h4>Sex Applicability</h4>
  • There are no Sexes associated with this Event
  • </div>
  • <!-- end sex terms -->
  • </div>
  • <!-- end bio org, life stage and sex terms -->
  • </div>
  • <!-- event text -->
  • <!-- end event text -->
  • </div>
  • </div>
  • <!-- end ke loop -->
  • <!-- loop for ao -->
  • <div id="ao">
  • <h2>Adverse Outcome</h2>
  • <hr>
  • <div>
  • <div>
  • <h3><strong>Event ID and Title</strong></h3>
  • <a href="/events/351">351: Increased, Mortality</a><br>
  • Short Name: Increased, Mortality
  • </div>
  • <div>
  • <h3>Key Event Overview</h3>
  • <!-- loop to find all aops that use this event -->
  • <h4>AOPs Including This Key Event</h4>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <div>
  • <h4><a href="/relationships/1345">Relationship: 1345: Increase, Ftz-f1 expression leads to Decrease, Circulating ETH</a></h4>
  • <h4>AOPs Referencing Relationship</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th>AOP ID and Name</th>
  • <th>Event Type</th>
  • <th scope="col">AOP Name</th>
  • <th scope="col">Adjacency</th>
  • <th scope="col">Weight of Evidence</th>
  • <th scope="col">Quantitative Understanding</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td><a href="/aops/16">16: Acetylcholinesterase inhibition leading to acute mortality</a></td>
  • <td>AdverseOutcome</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/96">96: Axonal sodium channel modulation leading to acute mortality</a></td>
  • <td>AdverseOutcome</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/104">104: Altered ion channel activity leading impaired heart function</a></td>
  • <td>AdverseOutcome</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/113">113: Glutamate-gated chloride channel activation leading to acute mortality</a></td>
  • <td>AdverseOutcome</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/160">160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality</a></td>
  • <td>AdverseOutcome</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/161">161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality</a></td>
  • <td>AdverseOutcome</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/138">138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality</a></td>
  • <td>AdverseOutcome</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/177">177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality</a></td>
  • <td>AdverseOutcome</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/186">186: unknown MIE leading to renal failure and mortality</a></td>
  • <td>AdverseOutcome</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/4">4: Ecdysone receptor agonism leading to mortality</a></td>
  • <td>AdverseOutcome</td>
  • </tr>
  • <tbody class="tbody-striped">
  • <tr>
  • <td><a href="/aops/4">Ecdysone receptor agonism leading to incomplete ecdysis associated mortality</a></td>
  • <td>adjacent</td>
  • <td>Moderate</td>
  • <td>Low</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- loop to find stressors under event -->
  • <div>
  • <h4>Stressors</h4>
  • The following are stressors that operate directly through this Event.
  • <div>
  • Will need to add a loop here once we have chemicals figured out
  • <ol>
  • <li>chemical one</li>
  • <li>chemical two</li>
  • </ol>
  • <br>
  • </div>
  • </div>
  • <!-- loop to find taxonomic applicability under event -->
  • <div>
  • <h4>Taxonomic Applicability</h4>
  • There are no Taxonomic Terms associated with this Event
  • <br>
  • <br>
  • </div>
  • <!-- end loop for taxons -->
  • <!-- biological organization, life stages and sex terms -->
  • <div>
  • <div class="row">
  • <!-- biological organization -->
  • <div class="col-md-4">
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Level of Biological Organization</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>Population</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- end of bio org -->
  • <!-- life stages -->
  • <div class="col-md-4">
  • <h4>Life Stage Applicability</h4>
  • There are no Life Stages associated with this Event
  • </div>
  • <!-- end life stages -->
  • <!-- sex terms -->
  • <div class="col-md-4">
  • <h4>Sex Applicability</h4>
  • There are no Sexes associated with this Event
  • </div>
  • <!-- end sex terms -->
  • </div>
  • <!-- end bio org, life stage and sex terms -->
  • </div>
  • <!-- event text -->
  • <!-- end event text -->
  • </div>
  • </div>
  • <!-- end ao loop -->
  • <!-- Evidence for relationship links section, this lists the relationships and then supports them -->
  • <div id="evidence_supporting_links">
  • <h2>Scientific evidence supporting the linkages in the AOP</h2>
  • <hr>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped" id="sortable_relationships" , data-aop-id="4" , data-update-path="/aops/4/aop_relationships/update_row_order">
  • <thead>
  • <div>
  • <h4><a href="/relationships/1346">Relationship: 1346: Decrease, Circulating ETH leads to Decrease, Circulating CCAP</a></h4>
  • <h4>AOPs Referencing Relationship</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th>ID</th>
  • <th>Upstream Event</th>
  • <th>Relationship Type</th>
  • <th>Downstream Event</th>
  • <th>Evidence</th>
  • <th>Quantitative Understanding</th>
  • <th scope="col">AOP Name</th>
  • <th scope="col">Adjacency</th>
  • <th scope="col">Weight of Evidence</th>
  • <th scope="col">Quantitative Understanding</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr data-item-id=1084 class="item">
  • <td>
  • <a href="/relationships/998">1084</a>
  • </td>
  • <td>
  • Activation, Ecdysone receptor
  • </td>
  • <td>
  • Directly leads to
  • </td>
  • <td>
  • Reduction, Release of circulating ecdysis triggering hormone
  • </td>
  • <td>
  • Moderate
  • </td>
  • <td>
  • Weak
  • </td>
  • </tr>
  • <tr data-item-id=1085 class="item">
  • <td>
  • <a href="/relationships/1008">1085</a>
  • </td>
  • <td>
  • Reduction, Release of circulating ecdysis triggering hormone
  • </td>
  • <td>
  • Directly leads to
  • </td>
  • <td>
  • Reduction, Abdominal muscle contraction
  • </td>
  • <td>
  • Moderate
  • </td>
  • <td>
  • Weak
  • </td>
  • </tr>
  • <tr data-item-id=1082 class="item">
  • <td>
  • <a href="/relationships/1010">1082</a>
  • </td>
  • <td>
  • Reduction, Abdominal muscle contraction
  • </td>
  • <td>
  • Directly leads to
  • </td>
  • <td>
  • Induction, Incomplete ecdysis
  • </td>
  • <td>
  • Moderate
  • </td>
  • <td>
  • Weak
  • </td>
  • </tr>
  • <tr data-item-id=1083 class="item">
  • <td>
  • <a href="/relationships/1190">1083</a>
  • </td>
  • <td>
  • Induction, Incomplete ecdysis
  • </td>
  • <td>
  • Directly leads to
  • </td>
  • <td>
  • Increased, Mortality
  • </td>
  • <td>
  • Strong
  • </td>
  • <td>
  • Strong
  • </td>
  • </tr>
  • <tbody class="tbody-striped">
  • <tr>
  • <td><a href="/aops/4">Ecdysone receptor agonism leading to incomplete ecdysis associated mortality</a></td>
  • <td>adjacent</td>
  • <td>Moderate</td>
  • <td>Low</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • <br>
  • <div>
  • <h3><strong>Relationship ID and Title: </strong></h3>
  • <a href="/relationships/998">4: Activation, EcR leads to Reduction, Release of circulating ETH</a>
  • <!--%= "#{relationship.directness}" %-->
  • <!-- if nothing shows up in any of these fields, then weight of evidence will not be displayed -->
  • </div>
  • <div>
  • <h3><strong>Relationship ID and Title: </strong></h3>
  • <a href="/relationships/1008">4: Reduction, Release of circulating ETH leads to Reduction, Abdominal muscle contraction</a>
  • <!--%= "#{relationship.directness}" %-->
  • <!-- if nothing shows up in any of these fields, then weight of evidence will not be displayed -->
  • <div>
  • <h4><a href="/relationships/1347">Relationship: 1347: Decrease, Circulating CCAP leads to Decrease, Ecdysis motoneuron bursts</a></h4>
  • <h4>AOPs Referencing Relationship</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP Name</th>
  • <th scope="col">Adjacency</th>
  • <th scope="col">Weight of Evidence</th>
  • <th scope="col">Quantitative Understanding</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td><a href="/aops/4">Ecdysone receptor agonism leading to incomplete ecdysis associated mortality</a></td>
  • <td>adjacent</td>
  • <td>Moderate</td>
  • <td>Low</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <div>
  • <h3><strong>Relationship ID and Title: </strong></h3>
  • <a href="/relationships/1010">4: Reduction, Abdominal muscle contraction leads to Induction, Incomplete ecdysis</a>
  • <!--%= "#{relationship.directness}" %-->
  • <!-- if nothing shows up in any of these fields, then weight of evidence will not be displayed -->
  • <div>
  • <h4><a href="/relationships/1348">Relationship: 1348: Decrease, Ecdysis motoneuron bursts leads to Decrease, Excitatory postsynaptic potential</a></h4>
  • <h4>AOPs Referencing Relationship</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP Name</th>
  • <th scope="col">Adjacency</th>
  • <th scope="col">Weight of Evidence</th>
  • <th scope="col">Quantitative Understanding</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td><a href="/aops/4">Ecdysone receptor agonism leading to incomplete ecdysis associated mortality</a></td>
  • <td>adjacent</td>
  • <td>Moderate</td>
  • <td>Low</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <div>
  • <h3><strong>Relationship ID and Title: </strong></h3>
  • <a href="/relationships/1190">4: Induction, Incomplete ecdysis leads to Increased, Mortality</a>
  • <!--%= "#{relationship.directness}" %-->
  • <!-- if nothing shows up in any of these fields, then weight of evidence will not be displayed -->
  • <div>
  • <h4><a href="/relationships/1349">Relationship: 1349: Decrease, Excitatory postsynaptic potential leads to Decrease, Abdominal muscle contraction</a></h4>
  • <h4>AOPs Referencing Relationship</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP Name</th>
  • <th scope="col">Adjacency</th>
  • <th scope="col">Weight of Evidence</th>
  • <th scope="col">Quantitative Understanding</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td><a href="/aops/4">Ecdysone receptor agonism leading to incomplete ecdysis associated mortality</a></td>
  • <td>adjacent</td>
  • <td>Moderate</td>
  • <td>Low</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <div>
  • <h4><a href="/relationships/1010">Relationship: 1010: Decrease, Abdominal muscle contraction leads to Increase, Incomplete ecdysis</a></h4>
  • <h4>AOPs Referencing Relationship</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP Name</th>
  • <th scope="col">Adjacency</th>
  • <th scope="col">Weight of Evidence</th>
  • <th scope="col">Quantitative Understanding</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td><a href="/aops/4">Ecdysone receptor agonism leading to incomplete ecdysis associated mortality</a></td>
  • <td>adjacent</td>
  • <td>Moderate</td>
  • <td>Low</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • <!-- end relationship loop -->
  • <!-- Overall assessment section, *** what is included here? *** -->
  • <div id="overall_assessment">
  • <h2>Overall Assessment of the AOP</h2>
  • <hr>
  • <h3>Applicability of the AOP</h3>
  • <div class="row">
  • <div class="col-md-6">
  • <h3>Life Stage Applicability</h3>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Life Stage</th>
  • <th>Evidence</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>Juvenile</td>
  • <td>Strong</td>
  • </tr>
  • <tr>
  • <td>Adult</td>
  • <td>Moderate</td>
  • </tr>
  • </tbody>
  • </table>
  • <div>
  • <h4><a href="/relationships/1002">Relationship: 1002: Increase, Incomplete ecdysis leads to Increase, Mortality</a></h4>
  • <h4>AOPs Referencing Relationship</h4>
  • <div class="table-responsive">
  • <table class="table table-bordered table-fullwidth">
  • <thead class="thead-light">
  • <tr>
  • <th scope="col">AOP Name</th>
  • <th scope="col">Adjacency</th>
  • <th scope="col">Weight of Evidence</th>
  • <th scope="col">Quantitative Understanding</th>
  • </tr>
  • </thead>
  • <tbody class="tbody-striped">
  • <tr>
  • <td><a href="/aops/4">Ecdysone receptor agonism leading to incomplete ecdysis associated mortality</a></td>
  • <td>adjacent</td>
  • <td>High</td>
  • <td>High</td>
  • </tr>
  • <tr>
  • <td><a href="/aops/466">Doda decarboxylase leading to mortality</a></td>
  • <td>adjacent</td>
  • <td>Moderate</td>
  • <td>Moderate</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • </div>
  • <div class="row">
  • <div class="col-md-10">
  • <h3>Taxon Applicability</h3>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Term</th>
  • <th>Scientific Term</th>
  • <th>Evidence</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>insects</td>
  • <td>insects</td>
  • <td>Strong</td>
  • </tr>
  • <tr>
  • <td>crustaceans</td>
  • <td>Daphnia magna</td>
  • <td>Moderate</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • </div>
  • <div class="row">
  • <div class="col-md-6">
  • <h3>Sex Applicability</h3>
  • <div class="panel panel-default">
  • <table class="table table-bordered table-striped">
  • <thead>
  • <tr>
  • <th>Sex</th>
  • <th>Evidence</th>
  • </tr>
  • </thead>
  • <tbody>
  • <tr>
  • <td>Unspecific</td>
  • <td>Moderate</td>
  • </tr>
  • </tbody>
  • </table>
  • </div>
  • </div>
  • </div>
  • </div>
  • <!-- potential consierations, text as entered by author -->
  • <div id="considerations_for_potential_applicaitons">
  • </div>
  • <!-- reference section, text as of right now but should be changed to be handled as table -->
  • <div id="references">
  • <h2>References</h2>
  • <hr>
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