Comments for Aop:440
Rex FitzGerald
On November 14, 2022 14:41
Dear Kalyan,
This is very valuable work, thank you.
First impressions:
You have "ovarian cancer" as AO in the title and diagram, but there is no corresponding KE in the AOPwiki, where the AOs are KE1053 and KE1054. I suggest you delete "ovarian cancer" from AOP title and diagram.
There are in fact multiple AOPs here (see enclosed ppt). To make it easier for external reviewers, these should be separated. I am aware that this problem is actually in AOP165 (Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse; US EPA, Charles Wood). Since I am not coaching AOP165, would you like to inform them about my comment? Otherwise I will contact them, no problem.
I have also noted an issue with the AOP Diagram in the enclosed ppt (a "T" arrow...).
A "non-coach" remark (as coach, I focus mainly on AOP structure, not scientific content, which is done by external reviewers): There is a useful recent publication from Johansson et al 2022 on estradiol and ovarian cancer risk which might be worth adding for overall AOP plausibility
https://pubmed.ncbi.nlm.nih.gov/35822202/
Another non-coach remark: KE1973 "Increased, estrogens"); how specific is this to granulosa cell estradiol? What about estrone and estriol? In other organs?
Thanks again, this will be an important AOP (or AOPs).
Best regards,
Rex FitzGerald, coach AOP440