Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 476 to 500 of 1141 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
666 increased signaling (GO:0023052) NADPH Oxidase (MESH:D019255) 1174: Activation, NADPH Oxidase
665 abnormal plasma membrane organization (GO:0007009) 1259: narcosis
664 decreased function (MI:0613) mitochondrion (GO:0005739) 1260: Direct mitochondrial inhibition
663 abnormal cellular component organization (GO:0016043) 1258: Decompartmentalization
662 occurrence Translocation, Genetic (MESH:D014178) 1253: MLL chromosomal translocation
661 abnormal DNA topoisomerase II activity (GO:0061505) 1252: Binding to (interferes with) topoisomerase II enzyme
660 abnormal Food Chain (MESH:D020387) 1210: Alteration, Food-web structures
659 increased male reproductive organ (UBERON:0003135) 1209: Induction, Male reproductive tract
658 increased male organism (UBERON:0003101) 1208: Increased, Male offspring
657 increased offspring quantity (VT:1000189) 1208: Increased, Male offspring
656 increased gene expression (GO:0010467) protein doublesex (fruit fly) (PR:P23023) 1206: Induction, Doublesex1 gene
655 increased signaling (GO:0023052) juvenile hormone (CHEBI:24943) 1205: Activation, Juvenile hormone receptor
654 increased second-messenger-mediated signaling (GO:0019932) 1242: Increased, Second Messenger Production
653 increased cell motility (GO:0048870) 1241: Increased, Motility
652 abnormal translation (GO:0006412) protein (PR:000000001) 1240: Altered, Protein Production
651 abnormal gene expression (GO:0010467) 1239: Altered, Gene Expression
650 increased angiogenesis (GO:0001525) 1213: Increased, Angiogenesis
649 decreased macrophage activation (GO:0042116) 1198: Activation, Macrophages
648 decreased cell activation (GO:0001775) 1197: Activation, Fibroblasts
647 increased epithelial cell (CL:0000066) 1196: Increased, Invasion
646 morphological change extracellular matrix (GO:0031012) 1195: modulation, Extracellular Matrix Composition
645 functional change deoxyribonucleic acid (CHEBI:16991) 1194: Increase, DNA damage
644 pathological Breast Neoplasms (MESH:D001943) 1193: N/A, Breast Cancer
643 increased signaling (GO:0023052) 1191: Increased, Non-genomic signaling
642 increased endothelial cell migration (GO:0043542) 1190: Increased, Migration (Endothelial Cells)