Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 676 to 700 of 1141 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
466 occurrence renal tubular necrosis (MP:0004154) 1097: Occurrence, renal proximal tubular necrosis
465 increased uric acid (CHEBI:27226)
464 decreased signaling (GO:0023052) solute carrier family 22 member 6 (PR:000014993) 877: Inhibition, organic anion transporter 1 (OAT1)
463 increased neoplasm (MP:0002006) olfactory segment of nasal mucosa (UBERON:0005386) 872: Increase, Site of Contact Nasal Tumors
462 increased Metaplasia (MESH:D008679) 869: Increase, Respiratory or Squamous Metaplasia
461 increased necrotic cell death (GO:0070265)
460 increased atrophy (MESH:D001284) olfactory epithelium (UBERON:0001997) 868: Increase, Tissue Degeneration, Necrosis & Atrophy
459 increased leukocyte mediated cytotoxicity (GO:0001909) 768: Increase, Cytotoxicity
458 decreased regulation of intracellular pH (GO:0051453) 867: Decrease, Intracellular pH
457 increased uroporphyrinogen (CHEBI:27258) 844: Oxidation, Uroporphyrinogen
456 increased porphyria (MP:0005654) 369: Uroporphyria
455 decreased catalytic activity (GO:0003824) uroporphyrinogen decarboxylase (PR:000017134) 845: Inhibition, UROD
454 increased gene expression (GO:0010467) cytochrome P450 1A5 (chicken) (PR:P79761) 850: Induction, CYP1A2/CYP1A5
453 increased gene expression (GO:0010467) cytochrome P450 1A2 (PR:000006102) 850: Induction, CYP1A2/CYP1A5
452 increased porphyrins (CHEBI:26214) 846: Accumulation, Highly carboxylated porphyrins
451 functional change lysosome (GO:0005764) 831: Disturbance, Lysosomal function
450 occurrence autophagic cell death (GO:0048102)
449 decreased phospholipase activity (GO:0004620) phospholipase A1 member A (human) (PR:Q53H76) 828: Inhibition, Phospholipase A
448 increased Microvesicular hepatic steatosis (HP:0001414) 838: Induction, Microvesicular fat
447 occurrence Mallory bodies (MP:0014045) 839: Formation, Mallory body
446 functional change Lipid bilayer of wall of lysosome (FMA:67514) 829: Damage, Lipid bilayer
445 occurrence podocyte vacuolization (MP:0011899) 824: Occurrence, Cytoplasmic vacuolization (podocyte)
444 occurrence Dilatation (MESH:D004106) renal tubule (UBERON:0009773) 823: Occurrence, Cystic dilatation (renal tubule)
443 occurrence autophagic cell death (GO:0048102) renal tubule (UBERON:0009773) 818: Occurrence, Cytoplasmic vacuolization (Renal tubule)
442 occurrence toxicity (MESH:Q000633) kidney (UBERON:0002113) 814: Occurrence, Kidney toxicity