Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 26 to 50 of 1141 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
1116 increased estrogen receptor activity (GO:0030284) estrogen receptor alpha complex (PR:000027727) 1065: Activation, estrogen receptor alpha
1115 decreased Decreased activity of mitochondrial complex III (HP:0011924) mitochondrial respiratory chain complex III (GO:0005750) 1542: Inhibition, Mitochondrial complex III
1114 increased peptide biosynthetic process (GO:0043043) 2371: Increased cortisol
1113 decreased G-protein coupled receptor signaling pathway (GO:0007186) alpha-1A adrenergic receptor (PR:000001183) 2370: Antagonism binding, α1-Adrenoreceptor
1112 increased cell proliferation (GO:0008283) homeobox protein SIX1 (PR:000014896) 1066: Promotion, Sine oculis homeobox 1 positive progenitor cells in endometrium
1111 increased translation (GO:0006412) homeobox protein SIX1 (PR:000014896) 2330: Sine oculis homeobox 1 protein expression, increased
1110 decreased cellular response to oxidative stress (GO:0034599) 1869: Diminished protective oxidative stress response
1109 increased Metaplasia (MESH:D008679) endometrium epithelium (UBERON:0004811) 1068: Endometrial squamous metaplasia, Increase
1108 increased Endometrial carcinoma (HP:0012114) adenosquamous carcinoma (MESH:D018196) 1070: Increased, adenosquamous carcinomas of endometrium
1107 increased Metaplasia (MESH:D008679) Squamous cell (FMA:66769)
1106 abnormal cell differentiation (GO:0030154) cell (GO:0005623) 1560: Cell differentiation, altered
1105 increased receptor agonist activity (GO:0048018) estrogen receptor (PR:000007204) 111: Agonism, Estrogen receptor
1104 increased increased synaptic depression (MP:0002916) CNS neuron (sensu Vertebrata) (CL:0000117) 1944: Synaptic dysfunction
1103 increased homeobox protein SIX1 (PR:000014896) None
1102 increased regulation of actin-dependent ATPase activity (GO:1904621) actin cytoskeleton (GO:0015629) 2078: Loss of drebrin
1101 decreased dendritic spine morphogenesis (GO:0060997) actin cytoskeleton (GO:0015629) 2078: Loss of drebrin
1100 increased NMDA glutamate receptor activity (GO:0004972) None
1099 increased abnormal long term potentiation (MP:0002207) drebrin (PR:000006296) 2242: Abnormality, dendritic spine morphology
1098 decreased long term synaptic depression (GO:0060292) drebrin (PR:000006296) 2242: Abnormality, dendritic spine morphology
1097 decreased Dementia (HP:0000726) drebrin (PR:000006296) 2242: Abnormality, dendritic spine morphology
1096 increased palatal shelves fail to meet at midline (MP:0009888) secondary palate (UBERON:0001716) 2041: Decrease, facial prominence outgrowth
1095 increased palatal shelves fail to meet at midline (MP:0009888) primary palate (UBERON:0005620) 2041: Decrease, facial prominence outgrowth
1094 decreased ovarian follicle development (GO:0001541) granulosa cell (CL:0000501) 1800: Granulosa cell proliferation of gonadotropin-independent follicles, Reduced
1093 decreased androgen receptor signaling pathway (GO:0030521) androgen receptor (PR:000004191) None
1092 arrested androgen receptor signaling pathway (GO:0030521) androgen receptor (PR:000004191) None