Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1126 to 1139 of 1139 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
1126 decreased protein import into nucleus, translocation (GO:0000060) androgen receptor (PR:000004191) 2393: Androgen receptor nuclear transcriptional activity in genital-tubercle tissues, reduced
1127 decreased regulation of DNA binding (GO:0051101) androgen (CHEBI:50113) 2393: Androgen receptor nuclear transcriptional activity in genital-tubercle tissues, reduced
1128 decreased mesenchymal-epithelial cell signaling (GO:0060638) fibroblast growth factor receptor 2 (PR:000001449) 2399: Fibroblast growth factor 10, fibroblast growth factor receptor 2 isoform IIIb signaling in genital tissue, reduced
1129 decreased mesenchymal-epithelial cell signaling (GO:0060638) fibroblast growth factor 10 (PR:000007480) 2399: Fibroblast growth factor 10, fibroblast growth factor receptor 2 isoform IIIb signaling in genital tissue, reduced
1130 decreased fibroblast growth factor 10 (PR:000007480) 2399: Fibroblast growth factor 10, fibroblast growth factor receptor 2 isoform IIIb signaling in genital tissue, reduced
1131 decreased fibroblast growth factor 2 (PR:000007489) None
1132 decreased cell activation (GO:0001775) fibroblast growth factor 2 (PR:000007489) 2399: Fibroblast growth factor 10, fibroblast growth factor receptor 2 isoform IIIb signaling in genital tissue, reduced
1133 disrupted external genitalia morphogenesis (GO:0035261) prepuce (UBERON:0011374) 2400: Preputial epithelial morphogenesis, disrupted
1134 delayed delayed balanopreputial separation (MP:0008940) prepuce of penis (UBERON:0001332) 2401: Male preputial separation, failed/delayed
1135 arrested delayed balanopreputial separation (MP:0008940) prepuce of penis (UBERON:0001332) 2401: Male preputial separation, failed/delayed
1136 decreased neuropeptide signaling pathway (GO:0007218) Metastin (CHEBI:80304) None
1137 increased regulation of steroid hormone biosynthetic process (GO:0090030) 17beta-estradiol (CHEBI:16469) 2402: Increased, estradiol (E2) production in ovaries
1138 increased neurotransmitter secretion (GO:0007269) Metastin (CHEBI:80304) 1985: Increased Kisspeptin levels in anteroventral periventricular nucleus (AVPV)
1139 increased increased circulating estradiol level (MP:0005182) 17beta-estradiol (CHEBI:16469) 2294: Plasma estradiol, increased