Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 101 to 125 of 1141 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
1041 increased T cell activation involved in immune response (GO:0002286) T cell (CL:0000084) None
1040 increased Celiac disease (HP:0002608) intestinal epithelial cell (CL:0002563) None
1039 increased cell activation involved in immune response (GO:0002263) B cell (CL:0000236) None
1038 increased cell activation involved in immune response (GO:0002263) Peyer's patch B cell (CL:0002402) None
1037 increased gene conversion of immunoglobulin genes (GO:0002206) B cell receptor complex (GO:0019815) None
1036 increased gene conversion (GO:0035822) alpha-beta T cell receptor complex (GO:0042105) None
1035 increased alpha-beta T cell receptor complex (GO:0042105) None
1034 increased antigen presentation trait (VT:0001835) Human leukocyte antigen complex (FMA:84795) None
1033 increased androgen biosynthetic process (GO:0006702) 17beta-hydroxy-5alpha-androstan-3-one (CHEBI:16330) 2273: Dihydrotestosterone (DHT) levels, increased
1032 increased aromatase (PR:000006100) None
1031 increased Immunosuppression (IDO:0000610) 984: Impairment, T-cell dependent antibody response
1030 increased regulation of androgen receptor signaling pathway (GO:0060765) androgen receptor (PR:000004191) 2274: Androgen receptor activation, increased
1029 increased hormone biosynthetic process (GO:0042446) 17beta-hydroxy-5alpha-androstan-3-one (CHEBI:16330) None
1028 increased testosterone biosynthetic process (GO:0061370) testosterone (CHEBI:17347) 2272: Testosterone levels, increased
1027 increased increased circulating LDL cholesterol level (MP:0000182) blood plasma (UBERON:0001969) None
1026 increased cholesterol biosynthetic process (GO:0006695) 2270: Increased, cholesterol synthesis enzymes
1025 increased increased circulating total protein level (MP:0005568) None
1024 decreased decreased circulating total protein level (MP:0005567) None
1023 increased CNS demyelination (HP:0007305) 2266: Demyelination, increased
1022 increased cell death (GO:0008219) oligodendrocyte (CL:0000128) 2265: Oligodendrocyte death, increased
1021 increased lysophosphatidylcholine (CHEBI:60479) 2263: Lysolecithin, increased
1020 decreased neuropathy target esterase (PR:000012946) 2262: Neuropathy target esterase, inhibited
1019 increased Stress, Physiological (MESH:D013312) heart (UBERON:0000948) 2239: Increased, Cardiac stress
1018 decreased blood circulation (GO:0008015) blood plasma (UBERON:0001969) 2261: Decreased, blood plasma volume
1017 decreased decreased circulating sodium level (MP:0005634) blood plasma (UBERON:0001969) 2237: Decreased, Plasma sodium concentrations