Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 476 to 500 of 1159 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
684 abnormal embryo development (GO:0009790) 1295: Defect of Embryogenesis
683 abnormal signaling (GO:0023052) Wnt signalosome (GO:1990909) 1294: Inhibition, Wnt pathway
682 increased signaling (GO:0023052) forkhead box protein O (Caenorhabditis elegans) (PR:O16850) 1293: Activation, FOXO
681 increased signaling (GO:0023052) JNK Mitogen-Activated Protein Kinases (MESH:D048031) 1292: Activation, JNK
680 abnormal glutathione (CHEBI:16856) 1290: Glutathione homeostasis
679 abnormal cholesterol (CHEBI:16113) 1289: Perturbation of cholesterol
678 decreased glutathione biosynthetic process (GO:0006750) glutathione (CHEBI:16856) 1287: Glutathione synthesis
677 decreased glutathione transferase activity (GO:0004364) glutathione S-transferase (PR:000029945) 1286: Down Regulation, GSS and GSTs gene
676 decreased glutathione synthase activity (GO:0004363) glutathione synthetase (PR:000008293) 1286: Down Regulation, GSS and GSTs gene
675 increased unsaturated fatty acid biosynthetic process (GO:0006636) unsaturated fatty acid (CHEBI:27208) 1285: Up Regulation, Unsaturated fatty acid
674 increased gene expression (GO:0010467) sterol regulatory element-binding protein 2 proteolytic cleavage product (PR:000021564) 1284: Up Regulation, SREBF2
673 increased signaling (GO:0023052) TGF-beta (PR:000000046) 1283: Activation, TGF-beta pathway
672 increased signaling (GO:0023052) signal transducer and transcription activator STAT (PR:000001933) 1282: Activation, JAK/STAT pathway
671 increased signaling (GO:0023052) Janus kinase (PR:000025748) 1282: Activation, JAK/STAT pathway
670 increased DNA repair (GO:0006281) deoxyribonucleic acid (CHEBI:16991) 1281: Increased, DNA Damage-Repair
669 increased signaling (GO:0023052) hypoxia-inducible factor 1 (Caenorhabditis elegans) (PR:G5EGD2) 1280: Activation, HIF-1
668 increased signaling (GO:0023052) map kinase p38 (PR:000003106) 1279: Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK
667 increased biosynthetic process (GO:0009058) reactive oxygen species (CHEBI:26523) None
666 increased signaling (GO:0023052) NADPH Oxidase (MESH:D019255) 1174: Activation, NADPH Oxidase
665 abnormal plasma membrane organization (GO:0007009) 1259: narcosis
664 decreased function (MI:0613) mitochondrion (GO:0005739) 1260: Direct mitochondrial inhibition
663 abnormal cellular component organization (GO:0016043) 1258: Decompartmentalization
662 occurrence Translocation, Genetic (MESH:D014178) 1253: MLL chromosomal translocation
661 abnormal DNA topoisomerase II activity (GO:0061505) 1252: Binding to (interferes with) topoisomerase II enzyme
660 abnormal Food Chain (MESH:D020387) 1210: Alteration, Food-web structures