Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 676 to 700 of 1159 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
484 decreased proteasome complex disassembly (GO:1903009) GTP cyclohydrolase 1 (PR:000007893) 935: KE2 : Decrease, GTPCH-1
483 decreased biosynthetic process (GO:0009058) 5,6,7,8-tetrahydrobiopterin (CHEBI:15372) 934: KE3 : Decrease, Tetrahydrobiopterin
482 occurrence mucus secretion (GO:0070254) None
481 decreased respiratory function trait (VT:0002327) 1250: Decrease, Lung function
480 increased secretion (GO:0046903) mucin-5AC (PR:000031343) None
479 increased gene expression (GO:0010467) mucin-5AC (PR:000031343) 962: Increase, Mucin production
478 increased cell proliferation (GO:0008283) goblet cell (CL:0000160) 923: Increase, Proliferation of goblet cells
477 occurrence hyperplasia (MESH:D006965) goblet cell (CL:0000160) 921: Occurrence, Hyperplasia of goblet cells
476 occurrence Metaplasia (MESH:D008679) goblet cell (CL:0000160) 920: Occurrence, Metaplasia of goblet cells
475 occurrence transdifferentiation (GO:0060290) ciliated epithelial cell (CL:0000067) 919: Occurrence, Transdifferentiation of ciliated epithelial cells
474 decreased epithelial cell apoptotic process (GO:1904019) None
473 occurrence epidermal growth factor-activated receptor activity (GO:0005006) epidermal growth factor receptor (PR:000006933) 941: Activation, EGFR
472 increased phosphorylation (GO:0016310) transcription factor Sp1 (PR:000000133) 924: Activation, Sp1
471 occurrence liver inflammation (MP:0001860) 902: Inflammation, Liver
470 occurrence organelle disassembly (GO:1903008) lysosome (GO:0005764) 898: Disruption, Lysosome
469 increased Neoplasms (MESH:D009369) 885: Increase, Cancer
468 increased Arrhythmias, Cardiac (MESH:D001145) 1106: Occurrence, cardiac arrhythmia
467 increased potassium atom (CHEBI:26216) 1098: Increased, blood potassium concentration
466 occurrence renal tubular necrosis (MP:0004154) 1097: Occurrence, renal proximal tubular necrosis
465 increased uric acid (CHEBI:27226)
464 decreased signaling (GO:0023052) solute carrier family 22 member 6 (PR:000014993) 877: Inhibition, organic anion transporter 1 (OAT1)
463 increased neoplasm (MP:0002006) olfactory segment of nasal mucosa (UBERON:0005386) 872: Increase, Site of Contact Nasal Tumors
462 increased Metaplasia (MESH:D008679) 869: Increase, Respiratory or Squamous Metaplasia
461 increased necrotic cell death (GO:0070265)
460 increased atrophy (MESH:D001284) olfactory epithelium (UBERON:0001997) 868: Increase, Tissue Degeneration, Necrosis & Atrophy