API

Aop: 139

AOP Title

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Alkylation of DNA leading to cancer 1

Short name:

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DNA alkylation -> cancer 1

Authors

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Carole Yauk

Environmental Health Centre Health Canada 50 Colombine Driveway Ottawa, ON Canada K1S 0K1

email: Carole.Yauk@canada.ca

Point of Contact

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Carole Yauk

Contributors

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  • Carole Yauk

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Alkylation, DNA September 16, 2017 10:14
N/A, Insufficient or incorrect DNA repair September 16, 2017 10:14
Increase, Mutations September 16, 2017 10:14
Increase, Cancer December 03, 2016 16:37
Alkylation, DNA leads to N/A, Insufficient or incorrect DNA repair November 29, 2016 19:53
N/A, Insufficient or incorrect DNA repair leads to Increase, Mutations November 29, 2016 19:57
Increase, Mutations leads to Increase, Cancer December 03, 2016 16:38
Alkylation, DNA leads to Increase, Mutations November 29, 2016 19:53
Alkylation, DNA leads to Increase, Cancer December 03, 2016 16:38

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Alkylation, DNA Alkylation, DNA

Key Events

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Title Short name
N/A, Insufficient or incorrect DNA repair N/A, Insufficient or incorrect DNA repair
Increase, Mutations Increase, Mutations

Adverse Outcome

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Title Short name
Increase, Cancer Increase, Cancer

Relationships Between Two Key Events (Including MIEs and AOs)

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Title Directness Evidence Quantitative Understanding
Alkylation, DNA leads to N/A, Insufficient or incorrect DNA repair Directly leads to Strong Moderate
N/A, Insufficient or incorrect DNA repair leads to Increase, Mutations Indirectly leads to Strong Moderate
Increase, Mutations leads to Increase, Cancer Indirectly leads to Moderate Weak
Alkylation, DNA leads to Increase, Mutations Indirectly leads to Strong Moderate
Alkylation, DNA leads to Increase, Cancer Indirectly leads to Moderate Weak

Network View

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Life Stage Applicability

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Life stage Evidence
All life stages Moderate

Taxonomic Applicability

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Term Scientific Term Evidence Link
Homo sapiens Homo sapiens NCBI
Mus musculus Mus musculus NCBI

Sex Applicability

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Sex Evidence
Mixed Moderate

Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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