API XML

Aop: 139

AOP Title

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Alkylation of DNA leading to cancer 1

Short name:

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DNA alkylation -> cancer 1

Graphical Representation

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Click to download graphical representation template

Authors

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Carole Yauk

Environmental Health Centre Health Canada 50 Colombine Driveway Ottawa, ON Canada K1S 0K1

email: Carole.Yauk@canada.ca

Point of Contact

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Carole Yauk   (email point of contact)

Contributors

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  • Carole Yauk

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Alkylation, DNA September 16, 2017 10:14
N/A, Insufficient or incorrect DNA repair September 16, 2017 10:14
Increase, Mutations September 16, 2017 10:14
Increase, Cancer December 03, 2016 16:37
Alkylation, DNA leads to N/A, Insufficient or incorrect DNA repair November 29, 2016 19:53
N/A, Insufficient or incorrect DNA repair leads to Increase, Mutations November 29, 2016 19:57
Increase, Mutations leads to Increase, Cancer December 03, 2016 16:38
Alkylation, DNA leads to Increase, Mutations November 29, 2016 19:53
Alkylation, DNA leads to Increase, Cancer December 03, 2016 16:38

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 97 Alkylation, DNA Alkylation, DNA
2 KE 155 N/A, Insufficient or incorrect DNA repair N/A, Insufficient or incorrect DNA repair
3 KE 185 Increase, Mutations Increase, Mutations
4 AO 885 Increase, Cancer Increase, Cancer

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Alkylation, DNA leads to N/A, Insufficient or incorrect DNA repair adjacent High Moderate
N/A, Insufficient or incorrect DNA repair leads to Increase, Mutations non-adjacent High Moderate
Increase, Mutations leads to Increase, Cancer non-adjacent Moderate Low
Alkylation, DNA leads to Increase, Mutations non-adjacent High Moderate
Alkylation, DNA leads to Increase, Cancer non-adjacent Moderate Low

Network View

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Stressors

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Life Stage Applicability

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Life stage Evidence
All life stages Moderate

Taxonomic Applicability

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Term Scientific Term Evidence Link
Homo sapiens Homo sapiens NCBI
Mus musculus Mus musculus NCBI

Sex Applicability

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Sex Evidence
Mixed Moderate

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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