API

Aop: 210

AOP Title

?


Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building

Short name:

?

JNK, FOXO and WNT alteration leading to reproductive failure: Multi-OMICS approach

Authors

?


Jinhee Choi, Nivedita Chatterjee, Youngho Kim, Jae-Seong Jeong

Point of Contact

?


Jinhee Choi

Contributors

?


  • Jinhee Choi

Status

?

Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development


This AOP was last modified on February 15, 2017 04:51

?

Revision dates for related pages

Page Revision Date/Time
Peptide Oxidation November 13, 2017 10:22
Activation, JNK September 16, 2017 10:17
Activation, FOXO September 16, 2017 10:17
Inhibition, Wnt pathway September 16, 2017 10:17
Defect of Embryogenesis September 16, 2017 10:17
Reproductive failure February 15, 2017 03:18
Peptide Oxidation leads to Activation, JNK February 15, 2017 04:49
Activation, JNK leads to Activation, FOXO February 15, 2017 04:49
Activation, FOXO leads to Inhibition, Wnt pathway February 15, 2017 04:49
Inhibition, Wnt pathway leads to Defect of Embryogenesis February 15, 2017 04:49
Defect of Embryogenesis leads to Reproductive failure February 15, 2017 04:49
Graphene oxide nanoparticles February 15, 2017 04:41

Abstract

?


Systems toxicology approach using integrated omics can provide a comprehensive insight into the mechanism of toxicity and metabolic effects when profile new chemical toxicity. The comprehensive toxic mechanism of stress response of graphene oxide was investigated in C. elegans using transcriptomics, metabolomics and lipidomics. Based on these results, we construct AOP for oxidative stress leading to reproductive failure in C. elegans. This AOP is constituted the KEs as increased oxidative stress and activation of c-Jun N-terminal kinase (JNK) and the activation of transcription factor DAF-16/FOXO, inhibition of WNT signaling, defect embryogenesis and AO as reproductive failure.


Background (optional)

?



Summary of the AOP

?



Stressors

?

Name Evidence Term
Graphene oxide nanoparticles

Molecular Initiating Event

?


Key Events

?

Title Short name
Peptide Oxidation Peptide Oxidation
Activation, JNK Activation, JNK
Activation, FOXO Activation, FOXO
Inhibition, Wnt pathway Inhibition, Wnt pathway
Defect of Embryogenesis Defect of Embryogenesis

Adverse Outcome

?

Title Short name
Reproductive failure Reproductive failure

Relationships Between Two Key Events (Including MIEs and AOs)

?

Network View

?

 

Life Stage Applicability

?

Life stage Evidence
All life stages

Taxonomic Applicability

?

Term Scientific Term Evidence Link
Caenorhabditis elegans Caenorhabditis elegans NCBI

Sex Applicability

?

Sex Evidence
Unspecific

Graphical Representation

?

Click to download graphical representation template

W1siziisijiwmtcvmdivmtuvogy3oxc1c3hhov9ktktfrk9yt19hbmrfv05ux2fsdgvyyxrpb25fbgvhzgluz190b19yzxbyb2r1y3rpdmvfzmfpbhvyzs5wbmcixsxbinailcj0ahvtyiisijuwmhg1mdaixv0?sha=7aaa95b0de38a863

Overall Assessment of the AOP

?



Domain of Applicability

?


Essentiality of the Key Events

?


Weight of Evidence Summary

?


Quantitative Considerations

?


Considerations for Potential Applications of the AOP (optional)

?



References

?