API

Aop: 215

AOP Title

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Molecular events lead to epilepsy

Short name:

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Molecular events lead to epilepsy

Authors

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Point of Contact

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Lyle Burgoon

Contributors

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  • Hsin-Yen Wu
  • Lyle Burgoon
  • Edward Perkins

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development


This AOP was last modified on July 24, 2017 15:36

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Revision dates for related pages

Page Revision Date/Time
Increase, seizure April 14, 2017 14:59
Activated, presynaptic neuron 1 June 02, 2017 11:29
Increased, glutamate June 02, 2017 11:32
Activated, NMDA receptor June 02, 2017 11:32
Increased, intracellular sodium (Na+) April 13, 2017 14:21
Activated, voltage-gated sodium channel June 02, 2017 11:32
Inhibit, voltage-gated sodium channel April 14, 2017 15:25
Treat, carbamazepine April 14, 2017 15:26
Activated, membrane depolarization June 02, 2017 11:32
Inactive, membrane depolarization April 14, 2017 15:28
Increased, RDX dose June 02, 2017 12:15
Repress, GABA-A receptor April 14, 2017 15:29
Activate, GABA-A receptor April 14, 2017 15:40
Activate, presynaptic neuron 2 April 14, 2017 15:39
Increase, GABA April 14, 2017 15:30
Increased, intracellular chloride (Cl-) April 13, 2017 14:21
Increased, hippocampal hyperdepolarization June 02, 2017 11:31
Increased, epilepsy June 02, 2017 12:17
Activated, presynaptic neuron 1 leads to Increased, glutamate April 14, 2017 15:33
Increased, glutamate leads to Activated, NMDA receptor April 14, 2017 15:34
Activated, NMDA receptor leads to Increased, intracellular sodium (Na+) April 14, 2017 15:34
Increased, intracellular sodium (Na+) leads to Activated, voltage-gated sodium channel April 14, 2017 15:34
Treat, carbamazepine leads to Inhibit, voltage-gated sodium channel April 14, 2017 15:34
Activated, voltage-gated sodium channel leads to Activated, membrane depolarization April 14, 2017 15:35
Activated, membrane depolarization leads to Increased, hippocampal hyperdepolarization April 14, 2017 15:35
Increased, hippocampal hyperdepolarization leads to Increase, seizure April 14, 2017 15:36
Increase, seizure leads to Increased, epilepsy April 14, 2017 15:36
Activate, presynaptic neuron 2 leads to Increase, GABA April 14, 2017 15:36
Increase, GABA leads to Activate, GABA-A receptor April 14, 2017 15:37
Increased, RDX dose leads to Activate, GABA-A receptor April 14, 2017 15:37
Activate, GABA-A receptor leads to Increased, intracellular chloride (Cl-) April 14, 2017 15:37
Increased, intracellular chloride (Cl-) leads to Inactive, membrane depolarization April 14, 2017 15:38

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Key Events

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Title Short name
Activated, presynaptic neuron 1 Activated, presynaptic neuron 1
Increased, glutamate Increased, glutamate
Activated, NMDA receptor Activated, NMDA receptor
Increased, intracellular sodium (Na+) Increased, intracellular sodium (Na+)
Activated, voltage-gated sodium channel Activated, voltage-gated sodium channel
Inhibit, voltage-gated sodium channel Inhibit, voltage-gated sodium channel
Treat, carbamazepine Treat, carbamazepine
Activated, membrane depolarization Activated, membrane depolarization
Inactive, membrane depolarization Inactive, membrane depolarization
Increased, RDX dose Increased, RDX dose
Repress, GABA-A receptor Repress, GABA-A receptor
Activate, GABA-A receptor Activate, GABA-A receptor
Activate, presynaptic neuron 2 Activate, presynaptic neuron 2
Increase, GABA Increase, GABA
Increased, intracellular chloride (Cl-) Increased, intracellular chloride (Cl-)

Adverse Outcome

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Title Short name
Increase, seizure Increase, seizure
Increased, hippocampal hyperdepolarization Increased, hippocampal hyperdepolarization
Increased, epilepsy Increased, epilepsy

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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