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Aop: 215

AOP Title

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Molecular events lead to epilepsy

Short name:

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Molecular events lead to epilepsy

Graphical Representation

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Click to download graphical representation template

Authors

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Point of Contact

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Lyle Burgoon   (email point of contact)

Contributors

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  • Hsin-Yen Wu
  • Lyle Burgoon
  • Edward Perkins

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development


This AOP was last modified on July 24, 2017 15:36

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Revision dates for related pages

Page Revision Date/Time
Increase, seizure April 14, 2017 14:59
Activated, presynaptic neuron 1 June 02, 2017 11:29
Increased, glutamate June 02, 2017 11:32
Activated, NMDA receptor June 02, 2017 11:32
Increased, intracellular sodium (Na+) April 13, 2017 14:21
Activated, voltage-gated sodium channel June 02, 2017 11:32
Inhibit, voltage-gated sodium channel April 14, 2017 15:25
Treat, carbamazepine April 14, 2017 15:26
Activated, membrane depolarization June 02, 2017 11:32
Inactive, membrane depolarization April 14, 2017 15:28
Increased, RDX dose June 02, 2017 12:15
Repress, GABA-A receptor April 14, 2017 15:29
Activate, GABA-A receptor April 14, 2017 15:40
Activate, presynaptic neuron 2 April 14, 2017 15:39
Increase, GABA April 14, 2017 15:30
Increased, intracellular chloride (Cl-) April 13, 2017 14:21
Increased, hippocampal hyperdepolarization June 02, 2017 11:31
Increased, epilepsy June 02, 2017 12:17
Activated, presynaptic neuron 1 leads to Increased, glutamate April 14, 2017 15:33
Increased, glutamate leads to Activated, NMDA receptor April 14, 2017 15:34
Activated, NMDA receptor leads to Increased, intracellular sodium (Na+) April 14, 2017 15:34
Increased, intracellular sodium (Na+) leads to Activated, voltage-gated sodium channel April 14, 2017 15:34
Treat, carbamazepine leads to Inhibit, voltage-gated sodium channel April 14, 2017 15:34
Activated, voltage-gated sodium channel leads to Activated, membrane depolarization April 14, 2017 15:35
Activated, membrane depolarization leads to Increased, hippocampal hyperdepolarization April 14, 2017 15:35
Increased, hippocampal hyperdepolarization leads to Increase, seizure April 14, 2017 15:36
Increase, seizure leads to Increased, epilepsy April 14, 2017 15:36
Activate, presynaptic neuron 2 leads to Increase, GABA April 14, 2017 15:36
Increase, GABA leads to Activate, GABA-A receptor April 14, 2017 15:37
Increased, RDX dose leads to Activate, GABA-A receptor April 14, 2017 15:37
Activate, GABA-A receptor leads to Increased, intracellular chloride (Cl-) April 14, 2017 15:37
Increased, intracellular chloride (Cl-) leads to Inactive, membrane depolarization April 14, 2017 15:38

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 KE 1349 Activated, presynaptic neuron 1 Activated, presynaptic neuron 1
2 KE 1350 Increased, glutamate Increased, glutamate
3 KE 1351 Activated, NMDA receptor Activated, NMDA receptor
4 KE 1321 Increased, intracellular sodium (Na+) Increased, intracellular sodium (Na+)
5 KE 1352 Activated, voltage-gated sodium channel Activated, voltage-gated sodium channel
6 KE 1353 Inhibit, voltage-gated sodium channel Inhibit, voltage-gated sodium channel
7 KE 1354 Treat, carbamazepine Treat, carbamazepine
8 KE 1355 Activated, membrane depolarization Activated, membrane depolarization
9 KE 1356 Inactive, membrane depolarization Inactive, membrane depolarization
10 KE 1357 Increased, RDX dose Increased, RDX dose
11 KE 1358 Repress, GABA-A receptor Repress, GABA-A receptor
12 KE 1359 Activate, GABA-A receptor Activate, GABA-A receptor
13 KE 1360 Activate, presynaptic neuron 2 Activate, presynaptic neuron 2
14 KE 1361 Increase, GABA Increase, GABA
15 KE 1322 Increased, intracellular chloride (Cl-) Increased, intracellular chloride (Cl-)
16 AO 1348 Increase, seizure Increase, seizure
17 AO 1362 Increased, hippocampal hyperdepolarization Increased, hippocampal hyperdepolarization
18 AO 1363 Increased, epilepsy Increased, epilepsy

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Activated, presynaptic neuron 1 leads to Increased, glutamate adjacent
Increased, glutamate leads to Activated, NMDA receptor adjacent
Activated, NMDA receptor leads to Increased, intracellular sodium (Na+) adjacent
Increased, intracellular sodium (Na+) leads to Activated, voltage-gated sodium channel adjacent
Treat, carbamazepine leads to Inhibit, voltage-gated sodium channel adjacent
Activated, voltage-gated sodium channel leads to Activated, membrane depolarization adjacent
Activated, membrane depolarization leads to Increased, hippocampal hyperdepolarization adjacent
Increased, hippocampal hyperdepolarization leads to Increase, seizure adjacent
Increase, seizure leads to Increased, epilepsy adjacent
Activate, presynaptic neuron 2 leads to Increase, GABA adjacent
Increase, GABA leads to Activate, GABA-A receptor adjacent
Increased, RDX dose leads to Activate, GABA-A receptor adjacent
Activate, GABA-A receptor leads to Increased, intracellular chloride (Cl-) adjacent
Increased, intracellular chloride (Cl-) leads to Inactive, membrane depolarization adjacent

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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