API

Aop: 217

AOP Title

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Gastric ulcer formation

Short name:

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Gastric ulcer formation

Authors

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Point of Contact

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Lyle Burgoon

Contributors

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  • Hsin-Yen Wu
  • Lyle Burgoon
  • Edward Perkins

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development


This AOP was last modified on July 24, 2017 15:37

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Revision dates for related pages

Page Revision Date/Time
Inhibit, gastric ulcer formation April 17, 2017 10:47
Inhibition, PTGS-1 (Prostaglandin-endoperoxide synthase 1) April 17, 2017 10:19
Activation, PTGS-1 (Prostaglandin-endoperoxide synthase 1) April 17, 2017 10:20
Activation, PTGS-2 (Prostaglandin-endoperoxide synthase 2) April 17, 2017 10:21
Inhibition, PTGS-2 (Prostaglandin-endoperoxide synthase 2) April 17, 2017 10:21
Increase, bicarbonate April 17, 2017 10:23
Increase, mucous April 17, 2017 10:23
Increase, mucosal blood flow April 17, 2017 10:24
Increase, platelet aggregation April 17, 2017 10:25
Increase, angiogenesis April 17, 2017 10:26
Decrease, leukocyte adherence April 17, 2017 10:27
Increase, leukocyte adherence April 17, 2017 10:28
Activate, leukocyte April 17, 2017 10:29
Activate, mucosal defense April 17, 2017 10:30
Increase, surfactant April 17, 2017 10:31
Decrease, surfactant April 17, 2017 10:32
Activate, phospholipase April 17, 2017 10:33
Increase, ammonium (NH4+) April 17, 2017 10:34
Activated, gastric ulcer formation June 02, 2017 10:26
Increase, angiogenesis leads to Inhibit, gastric ulcer formation April 17, 2017 10:49
Increase, platelet aggregation leads to Inhibit, gastric ulcer formation April 17, 2017 10:49
Activate, mucosal defense leads to Inhibit, gastric ulcer formation April 17, 2017 10:49
Activate, leukocyte leads to Activated, gastric ulcer formation April 17, 2017 10:50
Increase, leukocyte adherence leads to Activate, leukocyte April 17, 2017 10:50
Activation, PTGS-2 leads to Decrease, leukocyte adherence April 17, 2017 10:51
Activation, PTGS-2 leads to Increase, angiogenesis April 17, 2017 10:51
Activation, PTGS-1 leads to Increase, platelet aggregation April 17, 2017 10:52
Activation, PTGS-1 leads to Increase, mucosal blood flow April 17, 2017 10:52
Activation, PTGS-1 leads to Increase, mucous April 17, 2017 10:53
Activation, PTGS-1 leads to Increase, bicarbonate April 17, 2017 10:53
Increase, bicarbonate leads to Activate, mucosal defense April 17, 2017 10:54
Increase, mucous leads to Activate, mucosal defense April 17, 2017 10:54
Increase, mucosal blood flow leads to Activate, mucosal defense April 17, 2017 10:54
Increase, ammonium (NH4+) leads to Decrease, surfactant April 17, 2017 10:55
Activate, phospholipase leads to Decrease, surfactant April 17, 2017 10:55
Increase, surfactant leads to Activate, mucosal defense April 17, 2017 10:56
NonSteroidal Anti-Inflammatory Drugs (NSAID) April 17, 2017 10:12
Helicobacter pylori April 17, 2017 10:13

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Key Events

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Title Short name
Inhibition, PTGS-1 (Prostaglandin-endoperoxide synthase 1) Inhibition, PTGS-1
Activation, PTGS-1 (Prostaglandin-endoperoxide synthase 1) Activation, PTGS-1
Activation, PTGS-2 (Prostaglandin-endoperoxide synthase 2) Activation, PTGS-2
Inhibition, PTGS-2 (Prostaglandin-endoperoxide synthase 2) Inhibition, PTGS-2 (Prostaglandin-endoperoxide synthase 2)
Increase, bicarbonate Increase, bicarbonate
Increase, mucous Increase, mucous
Increase, mucosal blood flow Increase, mucosal blood flow
Increase, platelet aggregation Increase, platelet aggregation
Increase, angiogenesis Increase, angiogenesis
Decrease, leukocyte adherence Decrease, leukocyte adherence
Increase, leukocyte adherence Increase, leukocyte adherence
Activate, leukocyte Activate, leukocyte
Activate, mucosal defense Activate, mucosal defense
Increase, surfactant Increase, surfactant
Decrease, surfactant Decrease, surfactant
Activate, phospholipase Activate, phospholipase
Increase, ammonium (NH4+) Increase, ammonium (NH4+)

Adverse Outcome

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Title Short name
Inhibit, gastric ulcer formation Inhibit, gastric ulcer formation
Activated, gastric ulcer formation Activated, gastric ulcer formation

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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