API

Aop: 221

AOP Title

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Mental stress to depression

Short name:

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Mental stress to depression

Authors

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Point of Contact

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Lyle Burgoon

Contributors

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  • Hsin-Yen Wu
  • Edward Perkins
  • Lyle Burgoon

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development


This AOP was last modified on July 24, 2017 15:21

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Revision dates for related pages

Page Revision Date/Time
Reduced, BDNF (Brain-derived neurotrophic factor) May 31, 2017 17:30
Decreased, neuroplasticity May 31, 2017 16:45
Inactivated, 5-HTR (serotonin receptors) May 31, 2017 16:45
Decreased, extracellular serotonin May 31, 2017 16:46
Decreased, synaptic release May 31, 2017 16:46
Decreased, packaged serotonin May 31, 2017 16:46
Decreased, intracellular serotonin May 31, 2017 16:47
Decreased, serotonin transporter activity May 31, 2017 16:47
Increased, extracellular serotonin May 31, 2017 16:48
Increased, depression June 01, 2017 16:06
Reduce expression, BDNF (Brain-derived neurotrophic factor) May 31, 2017 16:40
Increased, glucocorticoid receptor activity May 31, 2017 17:27
Increased, glucocorticoid receptor activity leads to Reduced, BDNF May 31, 2017 17:31
Reduced, BDNF leads to Decreased, neuroplasticity May 31, 2017 17:32
Decreased, neuroplasticity leads to Increased, depression April 14, 2017 14:54
Decreased, extracellular serotonin leads to Inactivated, 5-HTR April 14, 2017 14:49
Decreased, serotonin transporter activity leads to Increased, extracellular serotonin April 14, 2017 14:46
Decreased, serotonin transporter activity leads to Decreased, intracellular serotonin April 14, 2017 14:47
Decreased, intracellular serotonin leads to Decreased, packaged serotonin April 14, 2017 14:47
Decreased, packaged serotonin leads to Decreased, synaptic release April 14, 2017 14:47
Decreased, synaptic release leads to Decreased, extracellular serotonin April 14, 2017 14:48
Increase cortisone levels (induced by stress) June 01, 2017 11:16

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Increased, glucocorticoid receptor activity Increased, glucocorticoid receptor activity

Key Events

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Title Short name
Reduced, BDNF (Brain-derived neurotrophic factor) Reduced, BDNF
Decreased, neuroplasticity Decreased, neuroplasticity
Inactivated, 5-HTR (serotonin receptors) Inactivated, 5-HTR
Decreased, extracellular serotonin Decreased, extracellular serotonin
Decreased, synaptic release Decreased, synaptic release
Decreased, packaged serotonin Decreased, packaged serotonin
Decreased, intracellular serotonin Decreased, intracellular serotonin
Decreased, serotonin transporter activity Decreased, serotonin transporter activity
Increased, extracellular serotonin Increased, extracellular serotonin
Reduce expression, BDNF (Brain-derived neurotrophic factor) Reduce expression, BDNF

Adverse Outcome

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Title Short name
Increased, depression Increased, depression

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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