API XML

Aop: 222

AOP Title

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Mental stress to agitation

Short name:

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Mental stress to agitation

Graphical Representation

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Click to download graphical representation template

Authors

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Point of Contact

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Lyle Burgoon   (email point of contact)

Contributors

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  • Hsin-Yen Wu
  • Edward Perkins
  • Lyle Burgoon

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development


This AOP was last modified on July 24, 2017 15:22

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Revision dates for related pages

Page Revision Date/Time
Increased, agitation June 01, 2017 11:35
Reduced, BDNF (Brain-derived neurotrophic factor) May 31, 2017 17:30
Reduce expression, BDNF (Brain-derived neurotrophic factor) May 31, 2017 16:40
Inactivated, 5-HTR (serotonin receptors) May 31, 2017 16:45
Decreased, neuroplasticity May 31, 2017 16:45
Decreased, extracellular serotonin May 31, 2017 16:46
Decreased, serotonin transporter activity May 31, 2017 16:47
Increased, extracellular serotonin May 31, 2017 16:48
Decreased, synaptic release May 31, 2017 16:46
Decreased, packaged serotonin May 31, 2017 16:46
Decreased, intracellular serotonin May 31, 2017 16:47
Increased, glucocorticoid receptor activity May 31, 2017 17:27
Increased, glucocorticoid receptor activity leads to Reduced, BDNF May 31, 2017 17:31
Reduce expression, BDNF leads to Decreased, neuroplasticity April 14, 2017 14:53
Decreased, neuroplasticity leads to Increased, agitation April 14, 2017 14:54
Inactivated, 5-HTR leads to Reduced, BDNF May 30, 2017 14:08
Decreased, extracellular serotonin leads to Inactivated, 5-HTR April 14, 2017 14:49
Decreased, serotonin transporter activity leads to Increased, extracellular serotonin April 14, 2017 14:46
Decreased, serotonin transporter activity leads to Decreased, intracellular serotonin April 14, 2017 14:47
Decreased, intracellular serotonin leads to Decreased, packaged serotonin April 14, 2017 14:47
Decreased, packaged serotonin leads to Decreased, synaptic release April 14, 2017 14:47
Decreased, synaptic release leads to Decreased, extracellular serotonin April 14, 2017 14:48
Increase cortisone levels (induced by stress) June 01, 2017 11:16

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 1396 Increased, glucocorticoid receptor activity Increased, glucocorticoid receptor activity
2 KE 1335 Reduced, BDNF (Brain-derived neurotrophic factor) Reduced, BDNF
3 KE 1329 Reduce expression, BDNF (Brain-derived neurotrophic factor) Reduce expression, BDNF
4 KE 1328 Inactivated, 5-HTR (serotonin receptors) Inactivated, 5-HTR
5 KE 1330 Decreased, neuroplasticity Decreased, neuroplasticity
6 KE 1347 Decreased, extracellular serotonin Decreased, extracellular serotonin
7 KE 1317 Decreased, serotonin transporter activity Decreased, serotonin transporter activity
8 KE 1320 Increased, extracellular serotonin Increased, extracellular serotonin
9 KE 1325 Decreased, synaptic release Decreased, synaptic release
10 KE 1324 Decreased, packaged serotonin Decreased, packaged serotonin
11 KE 1323 Decreased, intracellular serotonin Decreased, intracellular serotonin
12 AO 1345 Increased, agitation Increased, agitation

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Increased, glucocorticoid receptor activity leads to Reduced, BDNF adjacent
Reduce expression, BDNF leads to Decreased, neuroplasticity adjacent
Decreased, neuroplasticity leads to Increased, agitation adjacent
Inactivated, 5-HTR leads to Reduced, BDNF adjacent
Decreased, extracellular serotonin leads to Inactivated, 5-HTR adjacent
Decreased, serotonin transporter activity leads to Increased, extracellular serotonin adjacent
Decreased, serotonin transporter activity leads to Decreased, intracellular serotonin adjacent
Decreased, intracellular serotonin leads to Decreased, packaged serotonin adjacent
Decreased, packaged serotonin leads to Decreased, synaptic release adjacent
Decreased, synaptic release leads to Decreased, extracellular serotonin adjacent

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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