API

Aop: 223

AOP Title

?


Serotonin transporter activation to seizure

Short name:

?

Serotonin transporter activation to seizure

Authors

?


Point of Contact

?


Lyle Burgoon

Contributors

?


  • Hsin-Yen Wu
  • Edward Perkins
  • Lyle Burgoon

Status

?

Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development


This AOP was last modified on July 24, 2017 15:22

?

Revision dates for related pages

Page Revision Date/Time
Increased, extracellular serotonin May 31, 2017 16:48
Decreased, extracellular serotonin May 31, 2017 16:46
Increased, seizure June 01, 2017 11:55
Increased, serotonin transporter activity June 01, 2017 14:51
Increased, intracellular serotonin June 01, 2017 14:51
Increased, packaged serotonin June 01, 2017 14:52
Increased, synaptic release June 01, 2017 14:53
Decreased, 5-HT3 June 01, 2017 14:54
Increased, serotonin transporter activity leads to Increased, intracellular serotonin June 01, 2017 14:55
Increased, intracellular serotonin leads to Increased, packaged serotonin June 01, 2017 14:55
Increased, packaged serotonin leads to Increased, synaptic release June 01, 2017 14:56
Increased, synaptic release leads to Increased, extracellular serotonin June 01, 2017 14:56
Increased, serotonin transporter activity leads to Decreased, extracellular serotonin June 01, 2017 14:56
Increased, extracellular serotonin leads to Decreased, 5-HT3 June 01, 2017 14:57
Decreased, 5-HT3 leads to Increased, seizure June 01, 2017 14:58
serotonin transporter activation June 01, 2017 11:53

Abstract

?



Background (optional)

?


Larry: The serotonin transporter may be repressed by SSRI, thus extracellular serotonin is increased and seizure is reduced. However, I did not add this "SSRI inhibits serotonin transporter" relationship into the AOP since SSRI inhibition does not contribute directly to the AOP (It modified the MIE "the activation of serotonin transporter"), but it certainly could be a modifier to prevent the adverse outcome.


Summary of the AOP

?



Stressors

?

Molecular Initiating Event

?

Title Short name
Increased, serotonin transporter activity Increased, serotonin transporter activity

Key Events

?

Title Short name
Increased, extracellular serotonin Increased, extracellular serotonin
Decreased, extracellular serotonin Decreased, extracellular serotonin
Increased, intracellular serotonin Increased, intracellular serotonin
Increased, packaged serotonin Increased, packaged serotonin
Increased, synaptic release Increased, synaptic release
Decreased, 5-HT3 Decreased, 5-HT3

Adverse Outcome

?

Title Short name
Increased, seizure Increased, seizure

Relationships Between Two Key Events (Including MIEs and AOs)

?

Network View

?

 

Life Stage Applicability

?


Taxonomic Applicability

?


Sex Applicability

?


Graphical Representation

?

Click to download graphical representation template

Overall Assessment of the AOP

?



Domain of Applicability

?


Essentiality of the Key Events

?


Weight of Evidence Summary

?


Quantitative Considerations

?


Considerations for Potential Applications of the AOP (optional)

?



References

?