API

Aop: 224

AOP Title

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Serotonin transporter activation to depression

Short name:

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Serotonin transporter activation to depression

Authors

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Point of Contact

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Lyle Burgoon

Contributors

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  • Hsin-Yen Wu
  • Edward Perkins
  • Lyle Burgoon

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development


This AOP was last modified on July 24, 2017 15:23

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Revision dates for related pages

Page Revision Date/Time
Increased, depression June 01, 2017 16:06
Increased, extracellular serotonin May 31, 2017 16:48
Decreased, extracellular serotonin May 31, 2017 16:46
Increased, serotonin transporter activity June 01, 2017 14:51
Increased, intracellular serotonin June 01, 2017 14:51
Increased, packaged serotonin June 01, 2017 14:52
Increased, synaptic release June 01, 2017 14:53
Inactivated, 5-HTR (serotonin receptors) May 31, 2017 16:45
Reduce expression, BDNF (Brain-derived neurotrophic factor) May 31, 2017 16:40
Decreased, neuroplasticity May 31, 2017 16:45
Decreased, neuroplasticity leads to Increased, depression April 14, 2017 14:54
Reduce expression, BDNF leads to Decreased, neuroplasticity April 14, 2017 14:53
Inactivated, 5-HTR leads to Reduce expression, BDNF April 14, 2017 14:53
Decreased, extracellular serotonin leads to Inactivated, 5-HTR April 14, 2017 14:49
Increased, serotonin transporter activity leads to Decreased, extracellular serotonin June 01, 2017 14:56
Increased, serotonin transporter activity leads to Increased, intracellular serotonin June 01, 2017 14:55
Increased, intracellular serotonin leads to Increased, packaged serotonin June 01, 2017 14:55
Increased, packaged serotonin leads to Increased, synaptic release June 01, 2017 14:56
Increased, synaptic release leads to Increased, extracellular serotonin June 01, 2017 14:56
serotonin transporter activation June 01, 2017 11:53

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Increased, serotonin transporter activity Increased, serotonin transporter activity

Key Events

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Title Short name
Increased, intracellular serotonin Increased, intracellular serotonin
Increased, packaged serotonin Increased, packaged serotonin
Increased, synaptic release Increased, synaptic release
Increased, extracellular serotonin Increased, extracellular serotonin
Decreased, extracellular serotonin Decreased, extracellular serotonin
Inactivated, 5-HTR (serotonin receptors) Inactivated, 5-HTR
Reduce expression, BDNF (Brain-derived neurotrophic factor) Reduce expression, BDNF
Decreased, neuroplasticity Decreased, neuroplasticity

Adverse Outcome

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Title Short name
Increased, depression Increased, depression

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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