API XML

Aop: 224

AOP Title

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Serotonin transporter activation to depression

Short name:

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Serotonin transporter activation to depression

Graphical Representation

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Click to download graphical representation template

Authors

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Point of Contact

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Lyle Burgoon   (email point of contact)

Contributors

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  • Hsin-Yen Wu
  • Edward Perkins
  • Lyle Burgoon

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development


This AOP was last modified on July 24, 2017 15:23

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Revision dates for related pages

Page Revision Date/Time
Increased, depression June 01, 2017 16:06
Increased, extracellular serotonin May 31, 2017 16:48
Decreased, extracellular serotonin May 31, 2017 16:46
Increased, serotonin transporter activity June 01, 2017 14:51
Increased, intracellular serotonin June 01, 2017 14:51
Increased, packaged serotonin June 01, 2017 14:52
Increased, synaptic release June 01, 2017 14:53
Inactivated, 5-HTR (serotonin receptors) May 31, 2017 16:45
Reduce expression, BDNF (Brain-derived neurotrophic factor) May 31, 2017 16:40
Decreased, neuroplasticity May 31, 2017 16:45
Decreased, neuroplasticity leads to Increased, depression April 14, 2017 14:54
Reduce expression, BDNF leads to Decreased, neuroplasticity April 14, 2017 14:53
Inactivated, 5-HTR leads to Reduce expression, BDNF April 14, 2017 14:53
Decreased, extracellular serotonin leads to Inactivated, 5-HTR April 14, 2017 14:49
Increased, serotonin transporter activity leads to Decreased, extracellular serotonin June 01, 2017 14:56
Increased, serotonin transporter activity leads to Increased, intracellular serotonin June 01, 2017 14:55
Increased, intracellular serotonin leads to Increased, packaged serotonin June 01, 2017 14:55
Increased, packaged serotonin leads to Increased, synaptic release June 01, 2017 14:56
Increased, synaptic release leads to Increased, extracellular serotonin June 01, 2017 14:56
serotonin transporter activation June 01, 2017 11:53

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 1397 Increased, serotonin transporter activity Increased, serotonin transporter activity
2 KE 1398 Increased, intracellular serotonin Increased, intracellular serotonin
3 KE 1399 Increased, packaged serotonin Increased, packaged serotonin
4 KE 1400 Increased, synaptic release Increased, synaptic release
5 KE 1320 Increased, extracellular serotonin Increased, extracellular serotonin
6 KE 1347 Decreased, extracellular serotonin Decreased, extracellular serotonin
7 KE 1328 Inactivated, 5-HTR (serotonin receptors) Inactivated, 5-HTR
8 KE 1329 Reduce expression, BDNF (Brain-derived neurotrophic factor) Reduce expression, BDNF
9 KE 1330 Decreased, neuroplasticity Decreased, neuroplasticity
10 AO 1346 Increased, depression Increased, depression

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Decreased, neuroplasticity leads to Increased, depression adjacent
Reduce expression, BDNF leads to Decreased, neuroplasticity adjacent
Inactivated, 5-HTR leads to Reduce expression, BDNF adjacent
Decreased, extracellular serotonin leads to Inactivated, 5-HTR adjacent
Increased, serotonin transporter activity leads to Decreased, extracellular serotonin adjacent
Increased, serotonin transporter activity leads to Increased, intracellular serotonin adjacent
Increased, intracellular serotonin leads to Increased, packaged serotonin adjacent
Increased, packaged serotonin leads to Increased, synaptic release adjacent
Increased, synaptic release leads to Increased, extracellular serotonin adjacent

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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