API XML

Aop: 225

AOP Title

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Serotonin transporter activation to agitation

Short name:

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Serotonin transporter activation to agitation

Graphical Representation

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Click to download graphical representation template

Authors

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Point of Contact

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Lyle Burgoon   (email point of contact)

Contributors

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  • Hsin-Yen Wu
  • Edward Perkins
  • Lyle Burgoon

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development


This AOP was last modified on July 24, 2017 15:23

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Revision dates for related pages

Page Revision Date/Time
Increased, extracellular serotonin May 31, 2017 16:48
Decreased, extracellular serotonin May 31, 2017 16:46
Inactivated, 5-HTR (serotonin receptors) May 31, 2017 16:45
Reduce expression, BDNF (Brain-derived neurotrophic factor) May 31, 2017 16:40
Decreased, neuroplasticity May 31, 2017 16:45
Increased, agitation June 01, 2017 11:35
Increased, serotonin transporter activity June 01, 2017 14:51
Increased, intracellular serotonin June 01, 2017 14:51
Increased, packaged serotonin June 01, 2017 14:52
Increased, synaptic release June 01, 2017 14:53
Decreased, extracellular serotonin leads to Inactivated, 5-HTR April 14, 2017 14:49
Inactivated, 5-HTR leads to Reduce expression, BDNF April 14, 2017 14:53
Reduce expression, BDNF leads to Decreased, neuroplasticity April 14, 2017 14:53
Decreased, neuroplasticity leads to Increased, agitation April 14, 2017 14:54
Increased, serotonin transporter activity leads to Increased, intracellular serotonin June 01, 2017 14:55
Increased, intracellular serotonin leads to Increased, packaged serotonin June 01, 2017 14:55
Increased, packaged serotonin leads to Increased, synaptic release June 01, 2017 14:56
Increased, synaptic release leads to Increased, extracellular serotonin June 01, 2017 14:56
Increased, serotonin transporter activity leads to Decreased, extracellular serotonin June 01, 2017 14:56
serotonin transporter activation June 01, 2017 11:53

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 KE 1397 Increased, serotonin transporter activity Increased, serotonin transporter activity
2 KE 1398 Increased, intracellular serotonin Increased, intracellular serotonin
3 KE 1399 Increased, packaged serotonin Increased, packaged serotonin
4 KE 1320 Increased, extracellular serotonin Increased, extracellular serotonin
5 KE 1347 Decreased, extracellular serotonin Decreased, extracellular serotonin
6 KE 1328 Inactivated, 5-HTR (serotonin receptors) Inactivated, 5-HTR
7 KE 1329 Reduce expression, BDNF (Brain-derived neurotrophic factor) Reduce expression, BDNF
8 KE 1330 Decreased, neuroplasticity Decreased, neuroplasticity
9 KE 1400 Increased, synaptic release Increased, synaptic release
10 AO 1345 Increased, agitation Increased, agitation

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Decreased, extracellular serotonin leads to Inactivated, 5-HTR adjacent
Inactivated, 5-HTR leads to Reduce expression, BDNF adjacent
Reduce expression, BDNF leads to Decreased, neuroplasticity adjacent
Decreased, neuroplasticity leads to Increased, agitation adjacent
Increased, serotonin transporter activity leads to Increased, intracellular serotonin adjacent
Increased, intracellular serotonin leads to Increased, packaged serotonin adjacent
Increased, packaged serotonin leads to Increased, synaptic release adjacent
Increased, synaptic release leads to Increased, extracellular serotonin adjacent
Increased, serotonin transporter activity leads to Decreased, extracellular serotonin adjacent

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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