API

Aop: 226

AOP Title

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SSRI (Selective serotonin reuptake inhibitor) to hypertension

Short name:

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SSRI to hypertension

Authors

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Point of Contact

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Lyle Burgoon

Contributors

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  • Hsin-Yen Wu
  • Edward Perkins
  • Lyle Burgoon

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development


This AOP was last modified on July 24, 2017 15:23

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Revision dates for related pages

Page Revision Date/Time
Decreased, intracellular serotonin May 31, 2017 16:47
Decreased, packaged serotonin May 31, 2017 16:46
Decreased, synaptic release May 31, 2017 16:46
Increased, extracellular serotonin May 31, 2017 16:48
Decreased, extracellular serotonin May 31, 2017 16:46
Activation, 5-HT2A (Serotonin 2A) April 13, 2017 15:25
Activate, PLC (Phospholipase C) April 13, 2017 15:26
Increase, inositol triphosphate April 13, 2017 15:27
Increase, intracellular calcium April 13, 2017 15:27
Activate, calmodulin April 13, 2017 15:28
Increase, myosin light chain phosphorylation April 13, 2017 15:29
Increase, vascular smooth muscle contraction April 13, 2017 15:30
Increase, hypertension April 13, 2017 15:30
Decreased, serotonin transporter activity May 31, 2017 16:47
Decreased, serotonin transporter activity leads to Decreased, intracellular serotonin April 14, 2017 14:47
Decreased, intracellular serotonin leads to Decreased, packaged serotonin April 14, 2017 14:47
Decreased, packaged serotonin leads to Decreased, synaptic release April 14, 2017 14:47
Decreased, synaptic release leads to Decreased, extracellular serotonin April 14, 2017 14:48
Decreased, serotonin transporter activity leads to Increased, extracellular serotonin April 14, 2017 14:46
Increased, extracellular serotonin leads to Activation, 5-HT2A June 02, 2017 09:00
Activation, 5-HT2A leads to Activate, PLC April 14, 2017 14:50
Activate, PLC leads to Increase, inositol triphosphate April 14, 2017 14:50
Increase, inositol triphosphate leads to Increase, intracellular calcium April 14, 2017 14:50
Increase, intracellular calcium leads to Activate, calmodulin April 14, 2017 14:51
Activate, calmodulin leads to Increase, myosin light chain phosphorylation April 14, 2017 14:51
Increase, myosin light chain phosphorylation leads to Increase, vascular smooth muscle contraction April 14, 2017 14:51
Increase, vascular smooth muscle contraction leads to Increase, hypertension April 14, 2017 14:52
SSRI (Selective serotonin reuptake inhibitor) April 13, 2017 15:32

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Decreased, serotonin transporter activity Decreased, serotonin transporter activity

Key Events

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Title Short name
Decreased, intracellular serotonin Decreased, intracellular serotonin
Decreased, packaged serotonin Decreased, packaged serotonin
Decreased, synaptic release Decreased, synaptic release
Increased, extracellular serotonin Increased, extracellular serotonin
Decreased, extracellular serotonin Decreased, extracellular serotonin
Activation, 5-HT2A (Serotonin 2A) Activation, 5-HT2A
Activate, PLC (Phospholipase C) Activate, PLC
Increase, inositol triphosphate Increase, inositol triphosphate
Increase, intracellular calcium Increase, intracellular calcium
Activate, calmodulin Activate, calmodulin
Increase, myosin light chain phosphorylation Increase, myosin light chain phosphorylation
Increase, vascular smooth muscle contraction Increase, vascular smooth muscle contraction

Adverse Outcome

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Title Short name
Increase, hypertension Increase, hypertension

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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