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Aop: 227

AOP Title

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NSAID induced PTGS1 inactivation to gastric ulcer

Short name:

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NSAID induced PTGS1 inactivation to gastric ulcer

Graphical Representation

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Click to download graphical representation template

Authors

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Point of Contact

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Lyle Burgoon   (email point of contact)

Contributors

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  • Hsin-Yen Wu
  • Edward Perkins
  • Lyle Burgoon

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development


This AOP was last modified on July 24, 2017 15:23

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Revision dates for related pages

Page Revision Date/Time
Reduced, PTGS1 function June 02, 2017 10:25
Activated, gastric ulcer formation June 02, 2017 10:26
Reduced, platelet aggregation June 02, 2017 10:40
Decreased, mucosal blood flow June 02, 2017 10:41
Reduced, mucosal defense June 02, 2017 10:41
Decreased, mucous June 02, 2017 10:42
Decreased, bicarbonate June 02, 2017 10:43
Reduced, PTGS1 function leads to Reduced, platelet aggregation June 02, 2017 10:44
Reduced, platelet aggregation leads to Activated, gastric ulcer formation June 02, 2017 10:44
Reduced, PTGS1 function leads to Decreased, mucosal blood flow June 02, 2017 10:44
Decreased, mucosal blood flow leads to Reduced, mucosal defense June 02, 2017 10:44
Reduced, mucosal defense leads to Activated, gastric ulcer formation June 02, 2017 10:45
Reduced, PTGS1 function leads to Decreased, mucous June 02, 2017 10:45
Decreased, mucous leads to Reduced, mucosal defense June 02, 2017 10:45
Reduced, PTGS1 function leads to Decreased, bicarbonate June 02, 2017 10:46
Decreased, bicarbonate leads to Reduced, mucosal defense June 02, 2017 10:46
NSAID (Nonsteroidal anti-inflammatory drug) inhibits PTGS1 June 02, 2017 10:24

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 1402 Reduced, PTGS1 function Reduced, PTGS1 function
2 KE 1403 Reduced, platelet aggregation Reduced, platelet aggregation
3 KE 1404 Decreased, mucosal blood flow Decreased, mucosal blood flow
4 KE 1405 Reduced, mucosal defense Reduced, mucosal defense
5 KE 1406 Decreased, mucous Decreased, mucous
6 KE 1407 Decreased, bicarbonate Decreased, bicarbonate
7 AO 1385 Activated, gastric ulcer formation Activated, gastric ulcer formation

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Reduced, PTGS1 function leads to Reduced, platelet aggregation adjacent
Reduced, platelet aggregation leads to Activated, gastric ulcer formation adjacent
Reduced, PTGS1 function leads to Decreased, mucosal blood flow adjacent
Decreased, mucosal blood flow leads to Reduced, mucosal defense adjacent
Reduced, mucosal defense leads to Activated, gastric ulcer formation adjacent
Reduced, PTGS1 function leads to Decreased, mucous adjacent
Decreased, mucous leads to Reduced, mucosal defense adjacent
Reduced, PTGS1 function leads to Decreased, bicarbonate adjacent
Decreased, bicarbonate leads to Reduced, mucosal defense adjacent

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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