API

Aop: 227

AOP Title

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NSAID induced PTGS1 inactivation to gastric ulcer

Short name:

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NSAID induced PTGS1 inactivation to gastric ulcer

Authors

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Point of Contact

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Lyle Burgoon

Contributors

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  • Hsin-Yen Wu
  • Edward Perkins
  • Lyle Burgoon

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development


This AOP was last modified on July 24, 2017 15:23

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Revision dates for related pages

Page Revision Date/Time
Reduced, PTGS1 function June 02, 2017 10:25
Activated, gastric ulcer formation June 02, 2017 10:26
Reduced, platelet aggregation June 02, 2017 10:40
Decreased, mucosal blood flow June 02, 2017 10:41
Reduced, mucosal defense June 02, 2017 10:41
Decreased, mucous June 02, 2017 10:42
Decreased, bicarbonate June 02, 2017 10:43
Reduced, PTGS1 function leads to Reduced, platelet aggregation June 02, 2017 10:44
Reduced, platelet aggregation leads to Activated, gastric ulcer formation June 02, 2017 10:44
Reduced, PTGS1 function leads to Decreased, mucosal blood flow June 02, 2017 10:44
Decreased, mucosal blood flow leads to Reduced, mucosal defense June 02, 2017 10:44
Reduced, mucosal defense leads to Activated, gastric ulcer formation June 02, 2017 10:45
Reduced, PTGS1 function leads to Decreased, mucous June 02, 2017 10:45
Decreased, mucous leads to Reduced, mucosal defense June 02, 2017 10:45
Reduced, PTGS1 function leads to Decreased, bicarbonate June 02, 2017 10:46
Decreased, bicarbonate leads to Reduced, mucosal defense June 02, 2017 10:46
NSAID (Nonsteroidal anti-inflammatory drug) inhibits PTGS1 June 02, 2017 10:24

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Reduced, PTGS1 function Reduced, PTGS1 function

Key Events

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Title Short name
Reduced, platelet aggregation Reduced, platelet aggregation
Decreased, mucosal blood flow Decreased, mucosal blood flow
Reduced, mucosal defense Reduced, mucosal defense
Decreased, mucous Decreased, mucous
Decreased, bicarbonate Decreased, bicarbonate

Adverse Outcome

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Title Short name
Activated, gastric ulcer formation Activated, gastric ulcer formation

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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