API XML

Aop: 228

AOP Title

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NSAID induced PTGS2 inactivation to gastric ulcer

Short name:

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NSAID induced PTGS2 inactivation to gastric ulcer

Graphical Representation

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Click to download graphical representation template

Authors

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Point of Contact

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Lyle Burgoon   (email point of contact)

Contributors

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  • Hsin-Yen Wu
  • Edward Perkins
  • Lyle Burgoon

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development


This AOP was last modified on July 24, 2017 15:25

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Revision dates for related pages

Page Revision Date/Time
Reduced, PTGS2 function June 02, 2017 10:54
Activated, gastric ulcer formation June 02, 2017 10:26
Decreased, angiogenesis June 02, 2017 10:55
Increased, leukocyte adherence June 02, 2017 10:57
Increased, leukocyte activation June 02, 2017 10:57
Reduced, PTGS2 function leads to Decreased, angiogenesis June 02, 2017 10:58
Decreased, angiogenesis leads to Activated, gastric ulcer formation June 02, 2017 10:58
Reduced, PTGS2 function leads to Increased, leukocyte adherence June 02, 2017 10:58
Increased, leukocyte adherence leads to Increased, leukocyte activation June 02, 2017 10:58
Increased, leukocyte activation leads to Activated, gastric ulcer formation June 02, 2017 10:59
NSAID (Nonsteroidal anti-inflammatory drug) inhibits PTGS2 June 02, 2017 10:52

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 1408 Reduced, PTGS2 function Reduced, PTGS2 function
2 KE 1409 Decreased, angiogenesis Decreased, angiogenesis
3 KE 1410 Increased, leukocyte adherence Increased, leukocyte adherence
4 KE 1411 Increased, leukocyte activation Increased, leukocyte activation
5 AO 1385 Activated, gastric ulcer formation Activated, gastric ulcer formation

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Reduced, PTGS2 function leads to Decreased, angiogenesis adjacent
Decreased, angiogenesis leads to Activated, gastric ulcer formation adjacent
Reduced, PTGS2 function leads to Increased, leukocyte adherence adjacent
Increased, leukocyte adherence leads to Increased, leukocyte activation adjacent
Increased, leukocyte activation leads to Activated, gastric ulcer formation adjacent

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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