API

Aop: 228

AOP Title

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NSAID induced PTGS2 inactivation to gastric ulcer

Short name:

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NSAID induced PTGS2 inactivation to gastric ulcer

Authors

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Point of Contact

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Lyle Burgoon

Contributors

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  • Hsin-Yen Wu
  • Edward Perkins
  • Lyle Burgoon

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development


This AOP was last modified on July 24, 2017 15:25

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Revision dates for related pages

Page Revision Date/Time
Reduced, PTGS2 function June 02, 2017 10:54
Activated, gastric ulcer formation June 02, 2017 10:26
Decreased, angiogenesis June 02, 2017 10:55
Increased, leukocyte adherence June 02, 2017 10:57
Increased, leukocyte activation June 02, 2017 10:57
Reduced, PTGS2 function leads to Decreased, angiogenesis June 02, 2017 10:58
Decreased, angiogenesis leads to Activated, gastric ulcer formation June 02, 2017 10:58
Reduced, PTGS2 function leads to Increased, leukocyte adherence June 02, 2017 10:58
Increased, leukocyte adherence leads to Increased, leukocyte activation June 02, 2017 10:58
Increased, leukocyte activation leads to Activated, gastric ulcer formation June 02, 2017 10:59
NSAID (Nonsteroidal anti-inflammatory drug) inhibits PTGS2 June 02, 2017 10:52

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Reduced, PTGS2 function Reduced, PTGS2 function

Key Events

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Title Short name
Decreased, angiogenesis Decreased, angiogenesis
Increased, leukocyte adherence Increased, leukocyte adherence
Increased, leukocyte activation Increased, leukocyte activation

Adverse Outcome

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Title Short name
Activated, gastric ulcer formation Activated, gastric ulcer formation

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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