API XML

Aop: 229

AOP Title

?


Helicobacter pylori to gastric ulcer

Short name:

?

Helicobacter pylori to gastric ulcer

Graphical Representation

?

Click to download graphical representation template

Authors

?


Point of Contact

?


Lyle Burgoon   (email point of contact)

Contributors

?


  • Hsin-Yen Wu
  • Edward Perkins
  • Lyle Burgoon

Status

?

Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development


This AOP was last modified on July 24, 2017 15:25

?

Revision dates for related pages

Page Revision Date/Time
Helicobacter pylori infection June 02, 2017 11:08
Increase, ammonium (NH4+) April 17, 2017 10:34
Activate, phospholipase April 17, 2017 10:33
Decrease, surfactant April 17, 2017 10:32
Reduced, mucosal defense June 02, 2017 10:41
Activated, gastric ulcer formation June 02, 2017 10:26
Helicobacter pylori infection leads to Increase, ammonium (NH4+) June 02, 2017 11:11
Increase, ammonium (NH4+) leads to Decrease, surfactant April 17, 2017 10:55
Activate, phospholipase leads to Decrease, surfactant April 17, 2017 10:55
Decrease, surfactant leads to Reduced, mucosal defense June 02, 2017 11:12
Reduced, mucosal defense leads to Activated, gastric ulcer formation June 02, 2017 10:45
Helicobacter pylori infection June 02, 2017 11:07

Abstract

?



Background (optional)

?



Summary of the AOP

?


Events: Molecular Initiating Events (MIE)

?

Key Events (KE)

?

Adverse Outcomes (AO)

?

Sequence Type Event ID Title Short name
1 MIE 1412 Helicobacter pylori infection Helicobacter pylori infection
2 KE 1384 Increase, ammonium (NH4+) Increase, ammonium (NH4+)
3 KE 1383 Activate, phospholipase Activate, phospholipase
4 KE 1382 Decrease, surfactant Decrease, surfactant
5 KE 1405 Reduced, mucosal defense Reduced, mucosal defense
6 AO 1385 Activated, gastric ulcer formation Activated, gastric ulcer formation

Relationships Between Two Key Events
(Including MIEs and AOs)

?

Title Adjacency Evidence Quantitative Understanding
Helicobacter pylori infection leads to Increase, ammonium (NH4+) adjacent
Increase, ammonium (NH4+) leads to Decrease, surfactant adjacent
Activate, phospholipase leads to Decrease, surfactant adjacent
Decrease, surfactant leads to Reduced, mucosal defense adjacent
Reduced, mucosal defense leads to Activated, gastric ulcer formation adjacent

Network View

?

 

Stressors

?

Name Evidence Term
Helicobacter pylori infection

Life Stage Applicability

?

Taxonomic Applicability

?

Sex Applicability

?

Overall Assessment of the AOP

?



Domain of Applicability

?


Essentiality of the Key Events

?


Evidence Assessment

?


Quantitative Understanding

?


Considerations for Potential Applications of the AOP (optional)

?



References

?