API

Aop: 229

AOP Title

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Helicobacter pylori to gastric ulcer

Short name:

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Helicobacter pylori to gastric ulcer

Authors

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Point of Contact

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Lyle Burgoon

Contributors

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  • Hsin-Yen Wu
  • Edward Perkins
  • Lyle Burgoon

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development


This AOP was last modified on July 24, 2017 15:25

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Revision dates for related pages

Page Revision Date/Time
Helicobacter pylori infection June 02, 2017 11:08
Increase, ammonium (NH4+) April 17, 2017 10:34
Activate, phospholipase April 17, 2017 10:33
Decrease, surfactant April 17, 2017 10:32
Reduced, mucosal defense June 02, 2017 10:41
Activated, gastric ulcer formation June 02, 2017 10:26
Helicobacter pylori infection leads to Increase, ammonium (NH4+) June 02, 2017 11:11
Increase, ammonium (NH4+) leads to Decrease, surfactant April 17, 2017 10:55
Activate, phospholipase leads to Decrease, surfactant April 17, 2017 10:55
Decrease, surfactant leads to Reduced, mucosal defense June 02, 2017 11:12
Reduced, mucosal defense leads to Activated, gastric ulcer formation June 02, 2017 10:45
Helicobacter pylori infection June 02, 2017 11:07

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Name Evidence Term
Helicobacter pylori infection

Molecular Initiating Event

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Title Short name
Helicobacter pylori infection Helicobacter pylori infection

Key Events

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Title Short name
Increase, ammonium (NH4+) Increase, ammonium (NH4+)
Activate, phospholipase Activate, phospholipase
Decrease, surfactant Decrease, surfactant
Reduced, mucosal defense Reduced, mucosal defense

Adverse Outcome

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Title Short name
Activated, gastric ulcer formation Activated, gastric ulcer formation

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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