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Aop: 231

AOP Title

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presynaptic neuron 2 repression to epilepsy

Short name:

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presynaptic neuron 2 repression to epilepsy

Graphical Representation

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Click to download graphical representation template

Authors

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Point of Contact

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Lyle Burgoon   (email point of contact)

Contributors

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  • Hsin-Yen Wu
  • Edward Perkins
  • Lyle Burgoon

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development


This AOP was last modified on July 24, 2017 15:26

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Revision dates for related pages

Page Revision Date/Time
Reduced, presynaptic neuron 2 activity June 02, 2017 12:08
Increased, epilepsy June 02, 2017 12:17
Decreased, GABA June 02, 2017 12:09
Reduced, GABA-A receptor activation June 02, 2017 12:10
Decreased, intracellular chloride June 02, 2017 12:11
Activated, membrane depolarization June 02, 2017 11:32
Increased, hippocampal hyperdepolarization June 02, 2017 11:31
Increased, seizure June 01, 2017 11:55
Increased, RDX dose June 02, 2017 12:15
Reduced, presynaptic neuron 2 activity leads to Decreased, GABA June 02, 2017 12:12
Decreased, GABA leads to Reduced, GABA-A receptor activation June 02, 2017 12:12
Reduced, GABA-A receptor activation leads to Decreased, intracellular chloride June 02, 2017 12:13
Decreased, intracellular chloride leads to Activated, membrane depolarization June 02, 2017 12:13
Activated, membrane depolarization leads to Increased, hippocampal hyperdepolarization April 14, 2017 15:35
Increased, hippocampal hyperdepolarization leads to Increased, seizure June 02, 2017 11:41
Increased, seizure leads to Increased, epilepsy June 02, 2017 11:41
Increased, RDX dose leads to Reduced, GABA-A receptor activation June 02, 2017 12:14

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 1413 Reduced, presynaptic neuron 2 activity Reduced, presynaptic neuron 2 activity
2 KE 1414 Decreased, GABA Decreased, GABA
3 KE 1415 Reduced, GABA-A receptor activation Reduced, GABA-A receptor activation
4 KE 1416 Decreased, intracellular chloride Decreased, intracellular chloride
5 KE 1355 Activated, membrane depolarization Activated, membrane depolarization
6 KE 1362 Increased, hippocampal hyperdepolarization Increased, hippocampal hyperdepolarization
7 KE 1344 Increased, seizure Increased, seizure
8 KE 1357 Increased, RDX dose Increased, RDX dose
9 AO 1363 Increased, epilepsy Increased, epilepsy

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Reduced, presynaptic neuron 2 activity leads to Decreased, GABA adjacent
Decreased, GABA leads to Reduced, GABA-A receptor activation adjacent
Reduced, GABA-A receptor activation leads to Decreased, intracellular chloride adjacent
Decreased, intracellular chloride leads to Activated, membrane depolarization adjacent
Activated, membrane depolarization leads to Increased, hippocampal hyperdepolarization adjacent
Increased, hippocampal hyperdepolarization leads to Increased, seizure adjacent
Increased, seizure leads to Increased, epilepsy adjacent
Increased, RDX dose leads to Reduced, GABA-A receptor activation adjacent

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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