API

Aop: 231

AOP Title

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presynaptic neuron 2 repression to epilepsy

Short name:

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presynaptic neuron 2 repression to epilepsy

Authors

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Point of Contact

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Lyle Burgoon

Contributors

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  • Hsin-Yen Wu
  • Edward Perkins
  • Lyle Burgoon

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development


This AOP was last modified on July 24, 2017 15:26

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Revision dates for related pages

Page Revision Date/Time
Reduced, presynaptic neuron 2 activity June 02, 2017 12:08
Increased, epilepsy June 02, 2017 12:17
Decreased, GABA June 02, 2017 12:09
Reduced, GABA-A receptor activation June 02, 2017 12:10
Decreased, intracellular chloride June 02, 2017 12:11
Activated, membrane depolarization June 02, 2017 11:32
Increased, hippocampal hyperdepolarization June 02, 2017 11:31
Increased, seizure June 01, 2017 11:55
Increased, RDX dose June 02, 2017 12:15
Reduced, presynaptic neuron 2 activity leads to Decreased, GABA June 02, 2017 12:12
Decreased, GABA leads to Reduced, GABA-A receptor activation June 02, 2017 12:12
Reduced, GABA-A receptor activation leads to Decreased, intracellular chloride June 02, 2017 12:13
Decreased, intracellular chloride leads to Activated, membrane depolarization June 02, 2017 12:13
Activated, membrane depolarization leads to Increased, hippocampal hyperdepolarization April 14, 2017 15:35
Increased, hippocampal hyperdepolarization leads to Increased, seizure June 02, 2017 11:41
Increased, seizure leads to Increased, epilepsy June 02, 2017 11:41
Increased, RDX dose leads to Reduced, GABA-A receptor activation June 02, 2017 12:14

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Reduced, presynaptic neuron 2 activity Reduced, presynaptic neuron 2 activity

Key Events

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Title Short name
Decreased, GABA Decreased, GABA
Reduced, GABA-A receptor activation Reduced, GABA-A receptor activation
Decreased, intracellular chloride Decreased, intracellular chloride
Activated, membrane depolarization Activated, membrane depolarization
Increased, hippocampal hyperdepolarization Increased, hippocampal hyperdepolarization
Increased, seizure Increased, seizure
Increased, RDX dose Increased, RDX dose

Adverse Outcome

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Title Short name
Increased, epilepsy Increased, epilepsy

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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