API XML

Aop: 270

AOP Title

?


Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity

Short name:

?

Cellular ATP demand and locomotor performance

Graphical Representation

?

Click to download graphical representation template

W1siziisijiwmtgvmdgvmdqvntb6bgjzanvwm19druffsw1wywlyzwrfywn0axzpdhlfqu9qlmpwzyjdlfsiccisinrodw1iiiwintaweduwmcjdxq?sha=568d577b4796d6c6

Authors

?


Christopher G. Goodchild

Oklahoma State University

Department of Integrative Biology

Point of Contact

?


Christopher Goodchild   (email point of contact)

Contributors

?


  • Christopher Goodchild

Status

?

Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on August 03, 2018 20:56

?

Revision dates for related pages

Page Revision Date/Time

Abstract

?


The oxygen demand needed to facilitate elevated macromolecule catabolism and oxidative phosphorylation at the cellular level may alter energy allocation at the whole-organism level, causing impaired locomotor performance. For instance, contaminants that elevate oxygen demand for basal metabolism may reduce an organism's aerobic scope (i.e., [maximum metabolic rate - basal metabolic rate]) and reduced aerobic can impair locomotor performance.


Background (optional)

?



Summary of the AOP

?


Events: Molecular Initiating Events (MIE)

?

Key Events (KE)

?

Adverse Outcomes (AO)

?

Relationships Between Two Key Events
(Including MIEs and AOs)

?

Network View

?

 

Stressors

?

Life Stage Applicability

?

Taxonomic Applicability

?

Sex Applicability

?

Overall Assessment of the AOP

?



Domain of Applicability

?


Essentiality of the Key Events

?


Evidence Assessment

?


Quantitative Understanding

?


Considerations for Potential Applications of the AOP (optional)

?



References

?