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Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity
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- Christopher Goodchild
|Handbook Version||OECD status||OECD project|
This AOP was last modified on April 29, 2023 16:03
The oxygen demand needed to facilitate elevated macromolecule catabolism and oxidative phosphorylation at the cellular level may alter energy allocation at the whole-organism level, causing impaired locomotor performance. For instance, contaminants that elevate oxygen demand for basal metabolism may reduce an organism's aerobic scope (i.e., [maximum metabolic rate - basal metabolic rate]) and reduced aerobic can impair locomotor performance.