API XML

Aop: 53

AOP Title

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ER agonism leading to reduced survival due to renal failure

Short name:

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ER agonism : reduced survival

Graphical Representation

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Click to download graphical representation template

Authors

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Point of Contact

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Tom Hutchinson   (email point of contact)

Contributors

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  • Tom Hutchinson

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on January 27, 2018 15:34

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Revision dates for related pages

Page Revision Date/Time
Agonism, Estrogen receptor September 16, 2017 10:14
Increased, Vitellogenin synthesis September 16, 2017 10:15
Increase, Plasma vitellogenin concentrations September 16, 2017 10:14
Increased, renal vitellogenin deposition September 16, 2017 10:15
Increased, glomerular rupture and renal hemorrhaging September 16, 2017 10:15
Increased, nephropathy December 03, 2016 16:37

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 111 Agonism, Estrogen receptor Agonism, Estrogen receptor
2 KE 418 Increased, Vitellogenin synthesis Increased, Vitellogenin synthesis
3 KE 220 Increase, Plasma vitellogenin concentrations Increase, Plasma vitellogenin concentrations
4 KE 419 Increased, renal vitellogenin deposition Increased, renal vitellogenin deposition
5 KE 421 Increased, glomerular rupture and renal hemorrhaging Increased, glomerular rupture and renal hemorrhaging
6 KE 422 Increased, nephropathy Increased, nephropathy

Relationships Between Two Key Events
(Including MIEs and AOs)

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Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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