API

Aop: 53

AOP Title

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ER agonism leading to reduced survival due to renal failure

Short name:

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ER agonism : reduced survival

Authors

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Point of Contact

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Tom Hutchinson

Contributors

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  • Tom Hutchinson

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Agonism, Estrogen receptor September 16, 2017 10:14
Increased, Vitellogenin synthesis September 16, 2017 10:15
Increase, Plasma vitellogenin concentrations September 16, 2017 10:14
Increased, renal vitellogenin deposition September 16, 2017 10:15
Increased, glomerular rupture and renal hemorrhaging September 16, 2017 10:15
Increased, nephropathy December 03, 2016 16:37

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Agonism, Estrogen receptor Agonism, Estrogen receptor

Key Events

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Title Short name
Increased, Vitellogenin synthesis Increased, Vitellogenin synthesis
Increase, Plasma vitellogenin concentrations Increase, Plasma vitellogenin concentrations
Increased, renal vitellogenin deposition Increased, renal vitellogenin deposition
Increased, glomerular rupture and renal hemorrhaging Increased, glomerular rupture and renal hemorrhaging
Increased, nephropathy Increased, nephropathy

Adverse Outcome

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Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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