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AOP: 538
Title
Adverse outcome pathway of PFAS-induced vascular disrupting effects via activating oxidative stress related pathways
Short name
Graphical Representation
Point of Contact
Contributors
- Yanhong Wei
Coaches
OECD Information Table
OECD Project # | OECD Status | Reviewer's Reports | Journal-format Article | OECD iLibrary Published Version |
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This AOP was last modified on July 09, 2024 06:01
Revision dates for related pages
Page | Revision Date/Time |
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Oxidative Stress | November 15, 2024 10:33 |
The NO synthase pathway activation | July 09, 2024 05:56 |
increased,Vascular endothelial dysfunction | September 01, 2021 20:37 |
Increase, Vascular disrupting effects | August 19, 2023 20:12 |
Ferroptosis related pathways activation | July 09, 2024 06:00 |
Oxidative Stress leads to The NO synthase pathway activation | July 09, 2024 06:00 |
Oxidative Stress leads to Ferroptosis related pathways activation | July 09, 2024 06:01 |
The NO synthase pathway activation leads to increased,Vascular endothelial dysfunction | July 09, 2024 06:01 |
Ferroptosis related pathways activation leads to increased,Vascular endothelial dysfunction | July 09, 2024 06:01 |
increased,Vascular endothelial dysfunction leads to Increase, Vascular disrupting effects | July 09, 2024 06:01 |
Abstract
Perfluorinated and polyfluoroalkyl compounds are important chemical products, and their types, quantity and population exposure load are increasing year by year, and they are widely used in many fields, such as new fluorine-containing materials, fire protection, electroplating, semiconductors, photovoltaic, aerospace and many other fields. closely related to the development of high-end industry and national security, its potential vascular health hazards and vascular risk has become a major scientific issue of urgent concern all over the world. Traditional and emerging perfluorinated compounds have a wide variety and a large number. The assessment of cardiovascular developmental toxicity and health effects is an important scientific issue of urgent concern in China and the world. In order to effectively ensure the safety of the ecological environment and people's health, relevant regulations have been promulgated at home and abroad, and a number of human biological monitoring projects have been established, but the previous research conclusions on the relationship between traditional perfluorinated compounds and their substitutes and vascular developmental diseases are not consistent, and the harmful outcome path framework of traditional and emerging PFAS vascular interference has not been clarified. The purpose of this study is to clarify the mechanism and health effects of perfluorinated compounds exposure on oxidative stress related pathways, vascular injury and health effects from the point of view of toxicology and epidemiology, so as to lay a solid theoretical foundation for the screening, control and evaluation of perfluorinated and polyfluoroalkyl compounds.
AOP Development Strategy
Context
Strategy
Summary of the AOP
Events:
Molecular Initiating Events (MIE)
Key Events (KE)
Adverse Outcomes (AO)
Type | Event ID | Title | Short name |
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KE | 1392 | Oxidative Stress | Oxidative Stress |
KE | 2240 | The NO synthase pathway activation | The NO synthase pathway activation |
KE | 1928 | increased,Vascular endothelial dysfunction | increased,Vascular endothelial dysfunction |
KE | 2241 | Ferroptosis related pathways activation | Ferroptosis related pathways activation |
AO | 2161 | Increase, Vascular disrupting effects | Increase, Vascular disrupting effects |
Relationships Between Two Key Events (Including MIEs and AOs)
Title | Adjacency | Evidence | Quantitative Understanding |
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Oxidative Stress leads to The NO synthase pathway activation | adjacent | High | High |
Oxidative Stress leads to Ferroptosis related pathways activation | adjacent | High | Moderate |
The NO synthase pathway activation leads to increased,Vascular endothelial dysfunction | adjacent | High | High |
Ferroptosis related pathways activation leads to increased,Vascular endothelial dysfunction | adjacent | High | High |
increased,Vascular endothelial dysfunction leads to Increase, Vascular disrupting effects | adjacent | High | High |
Network View
Prototypical Stressors
Life Stage Applicability
Taxonomic Applicability
Sex Applicability
Overall Assessment of the AOP
Domain of Applicability
Essentiality of the Key Events
Evidence Assessment
Known Modulating Factors
Modulating Factor (MF) | Influence or Outcome | KER(s) involved |
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Quantitative Understanding
Considerations for Potential Applications of the AOP (optional)
References
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