API

Aop: 68

AOP Title

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Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome

Short name:

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Decreased Fetal Testosterone 3

Authors

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Gary Klinfelter

Point of Contact

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Gary Klinefelter

Contributors

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  • Gary Klinefelter

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Decreased sperm quantity / quality in the adult, Decreased fertility December 03, 2016 16:37
Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome December 03, 2016 16:37
Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells December 03, 2016 16:37
Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells December 03, 2016 16:37
Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells December 03, 2016 16:37

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome

Key Events

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Title Short name
Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells
Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells
Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells

Adverse Outcome

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Title Short name
Decreased sperm quantity / quality in the adult, Decreased fertility Decreased sperm quantity / quality in the adult, Decreased fertility

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Life stage Evidence
Foetal Strong
Adult, reproductively mature Moderate

Taxonomic Applicability

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Term Scientific Term Evidence Link
Rattus norvegicus Rattus norvegicus Strong NCBI

Sex Applicability

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Sex Evidence
Male Strong

Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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