API

Aop: 69

AOP Title

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Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell

Short name:

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Decrease Adult Testosterone

Authors

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Gary Klinefelter

Point of Contact

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Gary Klinefelter

Contributors

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  • Gary Klinefelter

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol September 16, 2017 10:15
Decreased Cholesterol, Decreased Uptake of Lipoproteins September 16, 2017 10:15
Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane December 03, 2016 16:37
Decreased Cholesterol, Decreased Testosterone Production by Adult Leydig Cells September 16, 2017 10:15
Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis December 03, 2016 16:37

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol
Decreased Cholesterol, Decreased Uptake of Lipoproteins Decreased Cholesterol, Decreased Uptake of Lipoproteins
Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membra

Key Events

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Title Short name
Decreased Cholesterol, Decreased Testosterone Production by Adult Leydig Cells Decreased Cholesterol, Decreased Testosterone Production by Adult Leydig Cells

Adverse Outcome

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Title Short name
Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Life stage Evidence
Adult, reproductively mature Strong

Taxonomic Applicability

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Term Scientific Term Evidence Link
Rattus norvegicus Rattus norvegicus Strong NCBI
Homo sapiens Homo sapiens Strong NCBI

Sex Applicability

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Sex Evidence
Male Strong

Graphical Representation

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Click to download graphical representation template

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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