API

Aop: 70

AOP Title

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Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell

Short name:

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Decreased Adult Testosterone 1

Authors

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Gary Klinefelter

Point of Contact

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Gary Klinefelter

Contributors

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  • Gary Klinefelter

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Decreased sperm quantity or quality in the adult, Decreased fertility December 03, 2016 16:37
Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell September 16, 2017 10:15
Decreased steroidogenesis, Decreased Activity of Steroidogenic Enzymes in Adult Leydig cells December 03, 2016 16:37
Decreased steroidogenesis, Increased Apoptosis of Adult Leydig Cells September 16, 2017 10:15
Decreased steroidogenesis, Alterations in the Leydig Cell Cytoskeleton September 16, 2017 10:15

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell

Key Events

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Title Short name
Decreased steroidogenesis, Decreased Activity of Steroidogenic Enzymes in Adult Leydig cells Decreased steroidogenesis, Decreased Activity of Steroidogenic Enzymes in Adult Leydig cell
Decreased steroidogenesis, Increased Apoptosis of Adult Leydig Cells Decreased steroidogenesis, Increased Apoptosis of Adult Leydig Cells
Decreased steroidogenesis, Alterations in the Leydig Cell Cytoskeleton Decreased steroidogenesis, Alterations in the Leydig Cell Cytoskeleton

Adverse Outcome

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Title Short name
Decreased sperm quantity or quality in the adult, Decreased fertility Decreased sperm quantity or quality in the adult, Decreased fertility

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Life stage Evidence
Adult, reproductively mature Strong

Taxonomic Applicability

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Term Scientific Term Evidence Link
Rattus norvegicus Rattus norvegicus Strong NCBI
Homo sapiens Homo sapiens Strong NCBI

Sex Applicability

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Sex Evidence
Male Strong

Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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