API XML

Aop: 70

AOP Title

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Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell

Short name:

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Decreased Adult Testosterone 1

Graphical Representation

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Click to download graphical representation template

Authors

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Gary Klinefelter

Point of Contact

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Gary Klinefelter   (email point of contact)

Contributors

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  • Gary Klinefelter

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on January 27, 2018 15:34

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Revision dates for related pages

Page Revision Date/Time
Decreased sperm quantity or quality in the adult, Decreased fertility December 03, 2016 16:37
Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell September 16, 2017 10:15
Decreased steroidogenesis, Decreased Activity of Steroidogenic Enzymes in Adult Leydig cells December 03, 2016 16:37
Decreased steroidogenesis, Increased Apoptosis of Adult Leydig Cells September 16, 2017 10:15
Decreased steroidogenesis, Alterations in the Leydig Cell Cytoskeleton September 16, 2017 10:15

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 640 Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell
2 KE 647 Decreased steroidogenesis, Decreased Activity of Steroidogenic Enzymes in Adult Leydig cells Decreased steroidogenesis, Decreased Activity of Steroidogenic Enzymes in Adult Leydig cell
3 KE 648 Decreased steroidogenesis, Increased Apoptosis of Adult Leydig Cells Decreased steroidogenesis, Increased Apoptosis of Adult Leydig Cells
4 KE 649 Decreased steroidogenesis, Alterations in the Leydig Cell Cytoskeleton Decreased steroidogenesis, Alterations in the Leydig Cell Cytoskeleton
5 AO 520 Decreased sperm quantity or quality in the adult, Decreased fertility Decreased sperm quantity or quality in the adult, Decreased fertility

Relationships Between Two Key Events
(Including MIEs and AOs)

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Network View

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Stressors

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Life Stage Applicability

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Life stage Evidence
Adult, reproductively mature High

Taxonomic Applicability

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Term Scientific Term Evidence Link
Rattus norvegicus Rattus norvegicus High NCBI
Homo sapiens Homo sapiens High NCBI

Sex Applicability

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Sex Evidence
Male High

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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