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Aop: 74

AOP Title

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Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis

Short name:

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Hypermethylation & Leydig Cells

Graphical Representation

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Click to download graphical representation template

Authors

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Gary Klinefelter

Point of Contact

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Gary Klinefelter   (email point of contact)

Contributors

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  • Gary Klinefelter

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on January 27, 2018 15:34

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Revision dates for related pages

Page Revision Date/Time
Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis December 03, 2016 16:37
Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis December 03, 2016 16:37
Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells December 03, 2016 16:37
Decreased testosterone by the fetal Leydig cells, Dysgensis of fetal Leydig cells December 03, 2016 16:37
Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells December 03, 2016 16:37

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 662 Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis
2 KE 655 Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells
3 KE 540 Decreased testosterone by the fetal Leydig cells, Dysgensis of fetal Leydig cells Decreased testosterone by the fetal Leydig cells, Dysgensis of fetal Leydig cells
4 KE 541 Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells
5 AO 543 Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult test

Relationships Between Two Key Events
(Including MIEs and AOs)

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Network View

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Stressors

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Life Stage Applicability

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Life stage Evidence
Foetal High
Adult, reproductively mature Moderate

Taxonomic Applicability

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Term Scientific Term Evidence Link
Rattus norvegicus Rattus norvegicus High NCBI

Sex Applicability

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Sex Evidence
Male High

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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