API

Aop: 74

AOP Title

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Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis

Short name:

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Hypermethylation & Leydig Cells

Authors

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Gary Klinefelter

Point of Contact

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Gary Klinefelter

Contributors

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  • Gary Klinefelter

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis December 03, 2016 16:37
Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis December 03, 2016 16:37
Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells December 03, 2016 16:37
Decreased testosterone by the fetal Leydig cells, Dysgensis of fetal Leydig cells December 03, 2016 16:37
Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells December 03, 2016 16:37

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis

Key Events

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Title Short name
Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells
Decreased testosterone by the fetal Leydig cells, Dysgensis of fetal Leydig cells Decreased testosterone by the fetal Leydig cells, Dysgensis of fetal Leydig cells
Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells

Adverse Outcome

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Title Short name
Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult test

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Life stage Evidence
Foetal Strong
Adult, reproductively mature Moderate

Taxonomic Applicability

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Term Scientific Term Evidence Link
Rattus norvegicus Rattus norvegicus Strong NCBI

Sex Applicability

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Sex Evidence
Male Strong

Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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