API XML

Aop: 99

AOP Title

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Histamine (H2) receptor antagonism leading to reduced survival

Short name:

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H2 block to reduced survival

Graphical Representation

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Click to download graphical representation template

Authors

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Kellie Fay

Point of Contact

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Kellie Fay   (email point of contact)

Contributors

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  • Kellie Fay

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on January 27, 2018 15:34

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Revision dates for related pages

Page Revision Date/Time
Decrease, histaminergic neuron excitation September 16, 2017 10:15
N/A, sedation December 03, 2016 16:37
Decreased, locomotion December 03, 2016 16:37
Decreased, survival December 03, 2016 16:37
Increased, predation December 03, 2016 16:37
Antagonism, Histamine Receptor (H2) September 16, 2017 10:15
Impairment, Learning and memory June 13, 2018 08:45
Decrease, histaminergic neuron excitation leads to N/A, sedation December 03, 2016 16:37
N/A, sedation leads to Decreased, locomotion December 03, 2016 16:37
Decreased, locomotion leads to Increased, predation December 03, 2016 16:37
Increased, predation leads to Decreased, survival December 03, 2016 16:37
Antagonism, Histamine Receptor (H2) leads to Decrease, histaminergic neuron excitation December 03, 2016 16:38
Decrease, histaminergic neuron excitation leads to Impairment, Learning and memory August 11, 2017 10:16
Impairment, Learning and memory leads to Decreased, locomotion August 11, 2017 10:16

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 638 Antagonism, Histamine Receptor (H2) Antagonism, Histamine Receptor (H2)
2 KE 633 Decrease, histaminergic neuron excitation Decrease, histaminergic neuron excitation
3 KE 634 N/A, sedation N/A, sedation
4 KE 635 Decreased, locomotion Decreased, locomotion
5 KE 341 Impairment, Learning and memory Impairment, Learning and memory
6 AO 636 Decreased, survival Decreased, survival
7 AO 588 Increased, predation Increased, predation

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Increased, predation leads to Decreased, survival adjacent
Antagonism, Histamine Receptor (H2) leads to Decrease, histaminergic neuron excitation adjacent
Decrease, histaminergic neuron excitation leads to N/A, sedation non-adjacent
N/A, sedation leads to Decreased, locomotion non-adjacent
Decreased, locomotion leads to Increased, predation non-adjacent
Decrease, histaminergic neuron excitation leads to Impairment, Learning and memory non-adjacent
Impairment, Learning and memory leads to Decreased, locomotion non-adjacent

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Term Scientific Term Evidence Link
zebrafish Danio rerio NCBI

Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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