API

Event: 1436

Key Event Title

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neurogenic inflammation of sensory nerves

Short name

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neurogenic inflammation

Biological Context

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Level of Biological Organization
Cellular

Cell term

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Organ term

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Key Event Components

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Process Object Action

Key Event Overview


AOPs Including This Key Event

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Stressors

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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Key Event Description

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C-fibres are understood to mediate adaptive cough responses in pathologic conditions, making them the likely neuronal basis of cough hypersensitivity.


How It Is Measured or Detected

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Domain of Applicability

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Evidence from human studies is lacking. Patients with idiopathic persistent cough had significantly higher calcitonin-gene-related peptide (CGRP)-containing nerve density in idiopathic cough patients.


References

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Song, W.-J., & Chang, Y.-S. (2015). Cough hypersensitivity as a neuro-immune interaction. Clinical and Translational Allergy, 5(1), 24. doi:10.1186/s13601-015-0069-4