API

Stressor: 110

Title

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Picrotoxin

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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AOP Evidence

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Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures

Picrotoxin seizures are well defined mechanistically. They arise from GABAA receptor chloride channel blockade. (See Page 131 in "Models of Seizures and Epilepsy", edited by A. Pitkanen, P.A. Schwartzkroin, S.L. Moshe. Elsevier Academic Press. 2006)

As picrotoxin effectively inhibits chloride influx in GABA-A and other ionotropic receptors, it represents a universal "reference" channel blocker with whom other ligands may be compared. (A.V. Kalueff. 2007. Mapping convulsants' binding to the GABA-A receptor chloride ionophore: a prposed model for channel binding sites. Neurochem Int. 50(1): 61-8.)




Event Evidence

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Binding at picrotoxin site, iGABAR chloride channel

There is no evidence text for this event.




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