AOPs Including This Stressor
|Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain||High|
Events Including This Stressor
|User term||DTXID||Preferred name||Casrn||jchem_inchi_key||indigo_inchi_key|
Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
Picrotoxin seizures are well defined mechanistically. They arise from GABAA receptor chloride channel blockade. (See Page 131 in "Models of Seizures and Epilepsy", edited by A. Pitkanen, P.A. Schwartzkroin, S.L. Moshe. Elsevier Academic Press. 2006)
As picrotoxin effectively inhibits chloride influx in GABAA and other ionotropic receptors, it represents a universal "reference" channel blocker with whom other ligands may be compared. (A.V. Kalueff. 2007. Mapping convulsants' binding to the GABA-A receptor chloride ionophore: a prposed model for channel binding sites. Neurochem Int. 50(1): 61-8.)
There is no evidence text for this event.