API

Stressor: 110

Title

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Picrotoxin

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Picrotoxin DTXSID7045605 Picrotoxin 124-87-8

AOP Evidence

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Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain

Picrotoxin seizures are well defined mechanistically. They arise from GABAA receptor chloride channel blockade. (See Page 131 in "Models of Seizures and Epilepsy", edited by A. Pitkanen, P.A. Schwartzkroin, S.L. Moshe. Elsevier Academic Press. 2006)

As picrotoxin effectively inhibits chloride influx in GABAA and other ionotropic receptors, it represents a universal "reference" channel blocker with whom other ligands may be compared. (A.V. Kalueff. 2007. Mapping convulsants' binding to the GABA-A receptor chloride ionophore: a prposed model for channel binding sites. Neurochem Int. 50(1): 61-8.)




Event Evidence

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Binding at picrotoxin site, iGABAR chloride channel

There is no evidence text for this event.




Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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References

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