API

Stressor: 112

Title

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Lindane

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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AOP Evidence

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Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures

Neurotoxic pesticides, such as lindane, alpha-endosulphan and dieldrin, share structural similiarity (and compete for the binding site) with picrotoxin, inhibit TBPS binding, induce seizures and block Cl-currents through ionophore. (A.V. Kalueff. 2007. Mapping convulsants' binding to the GABA-A receptor chloride ionophore: a prposed model for channel binding sites. Neurochem Int. 50(1): 61-8.)




Event Evidence

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Binding at picrotoxin site, iGABAR chloride channel

There is no evidence text for this event.




Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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References

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