AOPs Including This Stressor
|Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain||High|
Events Including This Stressor
|User term||DTXID||Preferred name||Casrn||jchem_inchi_key||indigo_inchi_key|
Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
Neurotoxic pesticides, such as lindane, a-endosulfan and dieldrin, share structural similiarity (and compete for the binding site) with picrotoxin, inhibit TBPS binding, induce seizures and block Cl-currents through ionophore. (A.V. Kalueff. 2007. Mapping convulsants' binding to the GABA-A receptor chloride ionophore: a prposed model for channel binding sites. Neurochem Int. 50(1): 61-8.)
There is no evidence text for this event.