Stressor: 127
Title
Nocodazole
Stressor Overview
AOPs Including This Stressor
| AOP Name | Evidence |
|---|---|
| Chemical binding to tubulin in oocytes leading to aneuploid offspring | High |
Events Including This Stressor
| Event Name |
|---|
| Binding, Tubulin |
Chemical Table
| User term | DTXID | Preferred name | Casrn | jchem_inchi_key | indigo_inchi_key |
|---|---|---|---|---|---|
| Nocodazole | DTXSID9031800 | Nocodazole | 31430-18-9 | KYRVNWMVYQXFEU-UHFFFAOYSA-N | KYRVNWMVYQXFEU-UHFFFAOYSA-N |
AOP Evidence
Chemical binding to tubulin in oocytes leading to aneuploid offspring
Sun et al (2005) Hyperhaploidy is significantly increased at 70 mg/kg. The percentages of hyperhaploid oocytes were 0.0 (0/230), 0.0 (0/194) and 7.3 (8/110) for controls, 35 and 70 mg/kg, respectively. The lowest effective dose roughly corresponds to an in vitro concentration of 230 µM, much higher than active concentrations on cultured oocytes. Poor water solubility and limited bioavailability of nocodazole after i.p. treatment likely account for this difference.
Event Evidence
Binding, Tubulin
There is no evidence text for this event.