API

Stressor: 127

Title

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Nocodazole

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Event Name
Binding, Tubulin

Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Nocodazole DTXSID9031800 Nocodazole 31430-18-9 KYRVNWMVYQXFEU-UHFFFAOYSA-N KYRVNWMVYQXFEU-UHFFFAOYSA-N

AOP Evidence

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Chemical binding to tubulin in oocytes leading to aneuploid offspring

Sun et al (2005) Hyperhaploidy is significantly increased at 70 mg/kg. The percentages of hyperhaploid oocytes were 0.0 (0/230), 0.0 (0/194) and 7.3 (8/110) for controls, 35 and 70 mg/kg, respectively. The lowest effective dose roughly corresponds to an in vitro concentration of 230 µM, much higher than active concentrations on cultured oocytes. Poor water solubility and limited bioavailability of nocodazole after i.p. treatment likely account for this difference.




Event Evidence

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Binding, Tubulin

There is no evidence text for this event.




Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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References

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