API

Stressor: 128

Title

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Benomyl

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Benomyl DTXSID5023900 Benomyl 17804-35-2 RIOXQFHNBCKOKP-UHFFFAOYSA-N RIOXQFHNBCKOKP-UHFFFAOYSA-N

AOP Evidence

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Chemical binding to tubulin in oocytes leading to aneuploid offspring

Mailhes and Aardema (1992) Hyperhaploidy is significantly increased at all doses tested. The percentages of hyperhaploid oocytes were 0.3 (1/309), 3.9 (6/155), 16.6 (38/229), 35.4 (46/130), 27.9 (60/215) and 29.4 (42/143) for controls, 500, 1000, 1500, 1750 and 2000 mg/kg, respectively. A saturation of the effect is detected for doses above 1500 mg/kg, but its cause is not investigated.




Event Evidence

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Binding, Tubulin

There is no evidence text for this event.



Altered, Chromosome number

Administration of benomyl ranging from 500 to  2000 mg/kg per os at the time of the induction of ovulation increased hyperhaploidy mouse oocytes at all doses tested (Mailhes and Aardema, 1992). A saturation of the effect is detected for doses above 1500 mg/kg




Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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References

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