API

Stressor: 13

Title

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Carbon tetrachloride

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Event Name
Alkylation, Protein

Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
carbon tetrachloride DTXSID8020250 Carbon tetrachloride 56-23-5 VZGDMQKNWNREIO-UHFFFAOYSA-N VZGDMQKNWNREIO-UHFFFAOYSA-N

AOP Evidence

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Protein Alkylation leading to Liver Fibrosis

Reference copound for this AOP




Event Evidence

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Alkylation, Protein

There is no evidence text for this event.




Stressor Info

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Chemical/Category Description

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Instructions

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Characterization of Exposure

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Instructions

To edit the “Characterization of Exposure” section, on a Stressor page, in the upper right hand menu, click ‘Edit.’ This brings you to a page entitled, “Editing Stressor.”  Scroll down to the “Characterization of Exposure”  section, where a text entry box allows you to submit text. Click ‘Update’ to save your changes and return to the Stressor page.  The new text should appear under the “Characterization of Exposure” section on the page.



References

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EPA Toxicological review of Carbon Tetrachloride (CAS No. 56-23-5). March 2010 EPA/635/R-08/005F available at: http://cfpub.epa.gov/ncea/iris/iris_documents/documents/toxreviews/0020tr.pdf accessed 24.10.2015.

Basu S. Carbon tetrachloride-induced lipid peroxidation: eicosanoid formation and their regulation by antioxidant nutrients. Toxicology. 2003 Jul 15;189(1-2):113-27.

Brattin WJ, Glende EA Jr, Recknagel RO. Pathological mechanisms in carbon tetrachloride hepatotoxicity. J Free Radic Biol Med. 1985;1(1):27-38.

Clawson GA. Mechanisms of carbon tetrachloride hepatotoxicity. Pathol Immunopathol Res. 1989;8(2):104-12.

Knockaert L, Berson A, Ribault C, Prost PE, Fautrel A, Pajaud J, et al. Carbon tetrachloride-mediated lipid peroxidation induces early mitochondrial alterations in mouse liver. Lab Invest. 2012 Mar;92(3):396-410.

Manibusan MK, Odin M, Eastmond DA. Postulated carbon tetrachloride mode of action: a review. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2007 Jul-Sep;25(3):185-209.