API

Stressor: 13

Title

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Carbon tetrachloride

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Event Name
Alkylation, Protein

Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
carbon tetrachloride DTXSID8020250 Carbon tetrachloride 56-23-5 VZGDMQKNWNREIO-UHFFFAOYSA-N VZGDMQKNWNREIO-UHFFFAOYSA-N

AOP Evidence

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Protein Alkylation leading to Liver Fibrosis

Reference copound for this AOP




Event Evidence

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Alkylation, Protein

There is no evidence text for this event.




Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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References

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EPA Toxicological review of Carbon Tetrachloride (CAS No. 56-23-5). March 2010 EPA/635/R-08/005F available at: http://cfpub.epa.gov/ncea/iris/iris_documents/documents/toxreviews/0020tr.pdf accessed 24.10.2015.

Basu S. Carbon tetrachloride-induced lipid peroxidation: eicosanoid formation and their regulation by antioxidant nutrients. Toxicology. 2003 Jul 15;189(1-2):113-27.

Brattin WJ, Glende EA Jr, Recknagel RO. Pathological mechanisms in carbon tetrachloride hepatotoxicity. J Free Radic Biol Med. 1985;1(1):27-38.

Clawson GA. Mechanisms of carbon tetrachloride hepatotoxicity. Pathol Immunopathol Res. 1989;8(2):104-12.

Knockaert L, Berson A, Ribault C, Prost PE, Fautrel A, Pajaud J, et al. Carbon tetrachloride-mediated lipid peroxidation induces early mitochondrial alterations in mouse liver. Lab Invest. 2012 Mar;92(3):396-410.

Manibusan MK, Odin M, Eastmond DA. Postulated carbon tetrachloride mode of action: a review. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2007 Jul-Sep;25(3):185-209.