API

Stressor: 145

Title

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Finasteride

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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AOP Evidence

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5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring

Finasteride is a type II 5alpha-reductase inhibitor that blocks conversion of testosterone to dihydrotestosterone (Clark et al 1990; Imperato-McGinley et al 1992). Intrauterine exposure in rats can result in shorter male AGD in male offspring (Bowman et al 2003; Christiansen et al 2009; Schwartz et al 2019)

References:

Bowman et al (2003), Toxicol Sci 74:393-406; doi: 10.1093/toxsci/kfg128

Christiansen et al (2009), Environ Health Perspect 117:1839-1846; doi: 10.1289/ehp.0900689

Clark et al (1990), Teratology 42:91-100; doi: 10.1002/tera.1420420111

Imperato-McGinley (1992), J Clin Endocrinol Metab 75:1022-1026; doi: 10.1210/jcem.75.4.1400866

Schwartz et al (2019), Toxicol Sci 169:303-311; doi: 10.1093/toxsci/kfz046



Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring

Intrauterine exposure in rats can result in shorter male AGD in male offspring as reported in:

Bowman et al (2003), Toxicol Sci 74:393-406; doi: 10.1093/toxsci/kfg128

Christiansen et al (2009), Environ Health Perspect 117:1839-1846; doi: 10.1289/ehp.0900689

Schwartz et al (2019), Toxicol Sci 169:303-311; doi: 10.1093/toxsci/kfz046

 

 




Event Evidence

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Inhibition, 5α-reductase activity

There is no evidence text for this event.



decrease, male anogenital distance

Finasteride has been shown to cause decreased male AGD in rats following intrauterine exposure to 100 mg/kg bw/day (Bowman et al, 2003).




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