API

Stressor: 149

Title

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Polychlorinated dibenzofurans

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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AOP Evidence

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Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF

Polychlorinated dibenzofurans (PCDFs) are potent AHR ligands (Denison et al. 2011). Recent reports indicate that 2,3,4,7,8-pentachlorodibenzofuran is more potent than TCDD, the prototypical AHR ligand, in some species of birds (Cohen-Barnhouse et al. 2011; Farmahin et al. 2013; Hervé et al. 2010).  2,3,7,8-tetrachlorodibenzofuran and 2,3,4,7,8-pentachlorodibenzofuran have been shown to induce cardiotoxicity in chicken embryos (Heid et al. 2001).  Variouse PCDF congener were shown to cause early life-stage mortality in ranbow trout (Walker and Peterson 1995; Walker et al. 1997).

References:

Denison, M. S., Soshilov, A. A., He, G., DeGroot, D. E., and Zhao, B. (2011). Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor. Toxicol. Sci. 124(1), 1-22.

Cohen-Barnhouse, A. M., Zwiernik, M. J., Link, J. E., Fitzgerald, S. D., Kennedy, S. W., Hervé, J. C., Giesy, J. P., Wiseman, S. B., Yang, Y., Jones, P. D., Wan, Y., Collins, B., Newsted, J. L., Kay, D. P., and Bursian, S. J. (2011b). Sensitivity of Japanese quail (Coturnix japonica), Common pheasant (Phasianus colchicus), and White Leghorn chicken (Gallus gallus domesticus) embryos to in ovo exposure to TCDD, PeCDF, and TCDF. Toxicol. Sci. 119(1), 93-103.

Farmahin, R., Manning, G. E., Crump, D., Wu, D., Mundy, L. J., Jones, S. P., Hahn, M. E., Karchner, S. I., Giesy, J. P., Bursian, S. J., Zwiernik, M. J., Fredricks, T. B., and Kennedy, S. W. (2013). Amino acid sequence of the ligand binding domain of the aryl hydrocarbon receptor 1 (AHR1) predicts sensitivity of wild birds to effects of dioxin-like compounds. Toxicol. Sci. 131(1), 139-152.

Hervé, J. C., Crump, D. L., McLaren, K. K., Giesy, J. P., Zwiernik, M. J., Bursian, S. J., and Kennedy, S. W. (2010). 2,3,4,7,8-pentachlorodibenzofuran is a more potent cytochrome P4501A inducer than 2,3,7,8-tetrachlorodibenzo-p-dioxin in herring gull hepatocyte cultures. Environ. Toxicol. Chem. 29(9), 2088-2095.

Walker, M.K.; Cook, P.M.; Butterworth, B.C.;  Zabel, E.W. and Peterson, R.E. (1995) Potency of a Complex Mixture of Polychlorinated Dibenzo-p-dioxin, Dibenzofuran, and Biphenyl Congeners Compared to 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Causing Fish Early Life Stage Mortality.  Fundamental and Applied Toxicology 30(2): 178-186.

Walker, M.K. and Peterson, R.E. (1991) Potencies of polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners, relative to 2,3,7,8-tetrachlorodibenzo-p-dioxin, for producing early life stage mortality in rainbow trout (Oncorhynchus mykiss) Aquatic Toxicology 21: 219-238.




Event Evidence

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Activation, AhR

Denison, M. S., Soshilov, A. A., He, G., DeGroot, D. E., and Zhao, B. (2011). Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor. Toxicol.Sci. 124, 1-22.



dimerization, AHR/ARNT

There is no evidence text for this event.




Stressor Info

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References

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